The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence

Blanco-Gandía, M. Carmen; Ledesma, Juan Carlos; Aracil-Fernández, Auxiliadora; Navarrete, Francisco; Montagud‐Romero, Sandra; Aguilar, M.A.; Manzanares, Jorge; Miñarro, José; Rodrı́guez-Arias, Marta

doi:10.1016/j.neuropharm.2017.04.040

Cited by 33 publications

(50 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug use during this critical period of development often predisposes to an increased likelihood of continued use into adulthood (Arteaga, Chen, & Reynolds, ). Moreover, social (e.g., peer influence), economic (e.g., low social status), hormonal (increase in adrenal and gonadal hormones), neurochemical (changes in DA neurotransmission) and dietary (high‐fat/sugar diets) conditions during adolescence also contribute to increased vulnerability to drug use (Blanco‐Gandía, Cantacorps et al., , Blanco‐Gandía, Ledesma et al., ; Spear, ). Social stress in early life, such as bullying at school or child abuse, can have several consequences in adulthood (de Groot, van Milligen, Moonen‐Leusen, Thomas, & Koolhaas, ; Lumley, Sipos, Charles, Charles, & Meyerhoff, ).…”

Section: Social Defeat Stress During Adolescencementioning

confidence: 99%

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Montagud‐Romero

Blanco-Gandía

Reguilón

et al. 2018

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.

show abstract

Section: Social Defeat Stress During Adolescencementioning

confidence: 99%

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Montagud‐Romero

Blanco-Gandía

Reguilón

et al. 2018

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…In summary, binge eating behavior is antecedent to binge eating disorder [ 2 ]. It was found that groups that were vulnerable to the development of binge eating behavior included both males and females from different age groups, including those in their childhood [ 3 , 4 ], during adolescence [ 5 , 6 ], and adulthood [ 7 , 8 ]. Therefore, the current study was mainly focused on binge eating behavior, a preliminary stage of binge eating disorder.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Binge Eating Behavior among Malaysian Adolescents

2018

View full text Add to dashboard Cite

Although there are numerous studies on binge eating behavior in the Western countries, studies on this behavior in Malaysia are still limited. Therefore, this cross-sectional study aimed to determine the risk factors associated with binge eating behavior among adolescents in Malaysia. The study included 356 adolescents (42.7% males and 57.3% females), aged 13 to 16 years. They completed a self-administered questionnaire on demographic and socioeconomic backgrounds, frequency of family meals, family meal environments, family cohesion, perception of body size, self-esteem, depressive symptoms, perfectionistic self-presentation, and binge eating behavior. Furthermore, their weight, height, and waist circumference were measured. It was found that 14.0% of the participants engaged in binge eating behavior (15.2% in females and 12.5% in males). Additionally, it was identified that high levels of depressive symptoms, high levels of body dissatisfaction, poor family cohesion, and low self-esteem were significantly contributed to binge eating behavior after controlling for sex (adjusted R2 = 0.165, F = 15.056, p < 0.001). The findings may suggest that improving the relationships between family members, along with eliminating adolescents’ negative emotions could help in the prevention of binge eating behavior among adolescents. The identified modifiable risk factors should be incorporated into binge eating preventive programs to increase the effectiveness of the programs.

show abstract

“…Interestingly, bingeing on fat during the adolescence led to a modulation of the rewarding effects of ethanol and increased vulnerability to some drug of abuse such as cocaine. This pattern of fat diet appears to exert its effects by influencing CB1 receptors in the NAc and ghrelin receptors in the VTA (Blanco‐Gandia et al, ). The withdrawal effects following food deprivation were analysed in other models too, with discrepant results based on the animal model studied (Cottone et al, ; Cottone, Sabino, Steardo, & Zorrilla, ; Parylak et al, ).…”

Section: Eating Beyond Metabolic Needs: the Nonhomeostatic Role Of Cementioning

confidence: 99%

Unravelling the role and mechanism of adipokine and gastrointestinal signals in animal models in the nonhomeostatic control of energy homeostasis: Implications for binge eating disorder

Novelle

Diéguez

2018

Euro Eating Disorders Rev

View full text Add to dashboard Cite

Central and peripheral signals regulating energy homeostasis interact tightly with neuronal pathways to modulate the hedonic component of food intake. Dysregulation of these interactions could explain the development of binge eating disorder (BED) and/or obesity and the increasing incidence of food addiction. In this review, we have highlighted the crucial role of peripheral hormones, such as leptin and ghrelin, among others, in these nonhomeostatic pathways. We have also emphasised the relevance of central cannabinoid pathway and lateral hypothalamus, with orexin and melanin‐concentrating hormone neurons, as the critical hub controlling motivation and reward. Throughout the manuscript, we have focused on mechanisms learned from animal models of BED/food addiction in order to understand how these peripheral signals can modulate the motivation to eat. Understanding these mechanisms could help us to develop new treatment options for BED and/or obesity.

show abstract

The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence

Cited by 33 publications

References 60 publications

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Factors Associated with Binge Eating Behavior among Malaysian Adolescents

Unravelling the role and mechanism of adipokine and gastrointestinal signals in animal models in the nonhomeostatic control of energy homeostasis: Implications for binge eating disorder

Contact Info

Product

Resources

About