The Rh blood group system: additional complexities

It is therefore postulated that the hybrid gene is responsible for the weak expression of C in these individuals. The hybrid gene carried a Leu62Phe substitution, as well as the Leu245Val substitution responsible for VS. The gene most probably cosegregates with a C allele encoding Cys 16 (normally encoded only by the C allele) and Val245 (responsible for VS antigenicity when encoded by the RHCE gene). This explains the combination of weak expression of C and VS positivity that is frequently found in blacks.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Rh blood group system: additional complexities

Abstract: Since its discovery more than 50 years ago,1,2 the Rh blood group system has continued to challenge, intrigue, tantalize, and (too often) obfuscate blood group serologists. It is fitting that this issue of

Cited by 6 publications

References 74 publications

RHD gene polymorphisms in alloimmunized RhD-negative individuals with high rate of racial admixture

RHD gene polymorphisms in alloimmunized RhD-negative individuals with high rate of racial admixture

Involvement of Ser103 of the Rh polypeptides in G epitope formation

Molecular background of VS and weak C expression in blacks

Contact Info

Product

Resources

About