The risk of bone cancer in man from internally deposited radium

Evans, Robley D.; Finkel, Asher; Hasterlik, Robert J.; Keane, A.T.; Kolenkow, R. J.; Neal, W. R.; Shanahan, M. M.

doi:10.1259/0007-1285-41-485-391

Cited by 9 publications

(5 citation statements)

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“…However, its coveted effects are tempered by lower body temperature and smaller body size [154]. While CR diminishes the risk of carcinogenesis by lengthening the latent period, radiation acts in the exact opposite manner, causing excess cancers by diminishing the latent period [126,155]. Similarly, while CR appears to suppress age-related increases in ROS, apoptosis and inflammation, IR generally enhances these effects [16,53, 64,65,157].…”

Section: Discussionmentioning

confidence: 99%

“…Female U.S. radium-dial painters were first exposed to 226,228 Ra at 20±5 years of age; and bone sarcomas appeared on average 27±14 years later [125]. The higher the radium activity (and dose), beyond a threshold value of 2 MBq, the shorter the latent period [126]. At low doses, the radiation-induced aging effect and the reduction in the latent period (from exposure to the cancer's appearance) are small.…”

Section: Comparison Of Aging and Radiation Effectsmentioning

confidence: 99%

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Ionizing radiation and aging: rejuvenating an old idea

Richardson

2009

Aging

119

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This paper reviews the contemporary evidence that radiation can accelerate aging, degenerative health effects and mortality. Around the 1960s, the idea that ionizing radiation caused premature aging was dismissed as the radiation-induced health effects appeared to be virtually confined to neoplasms. More recently, radiation has become associated with a much wider spectrum of age-related diseases, including cardiovascular disease; although some diseases of old age, such as diabetes, are notably absent as a radiation risk. On the basis of recent research, is there a stronger case today to be made linking radiation and aging? Comparison is made between the now-known biological mechanisms of aging and those of radiation, including oxidative stress, chromosomal damage, apoptosis, stem cell exhaustion and inflammation. The association between radiation effects and the free-radical theory of aging as the causative hypothesis seems to be more compelling than that between radiation and the nutrient-sensing TOR pathway. Premature aging has been assessed by biomarkers in calorie restriction studies; yet, biomarkers such as telomere erosion and p16INK4a are ambiguous for radiation-induced aging. Some animal studies suggest low dose radiation may even demonstrate hormesis health benefits. Regardless, there is virtually no support for a life span extending hypothesis for A-bomb survivors and other exposed subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Aging and Radiation Effectsmentioning

confidence: 99%

Ionizing radiation and aging: rejuvenating an old idea

Richardson

2009

Aging

119

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“…For intravenous administration in cancer therapy, the risks of carcinogenesis also depend highly on the amount administered and radiation dose to the most affected organs and tissues. Although scientific experience with injected 223 RaCl 2 is relatively recent (Parker et al , 2013), a vast amount of information is known on the carcinogenic risks associated with cationic 224 Ra, 226 Ra, and 228 Ra in the incidence of soft-tissue sarcoma, osteosarcoma, sinus/ mastoid carcinoma, and leukemia induction (Evans, 1967; Evans et al , 1969; 1972; Finkel et al , 1969; Rowland, 1994; Spiess et al , 1962; Van Alyea, 1939). The short physical half-lives of therapeutic alpha emitters (from 46 min for 213 Bi to 11.4 days for 223 Ra) limit the risks normally associated with long-term retention but greatly magnify the localized dose rate.…”

Section: Radiobiology and Bioeffect Modelingmentioning

confidence: 99%

ICRU REPORT 96, Dosimetry-Guided Radiopharmaceutical Therapy

et al. 2021

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The Commission wishes to express its appreciation to the individuals involved in the preparation of this Report for the time and efforts that they devoted to this task and to express its appreciation to the organizations with which they are affiliated.All rights reserved. No part of this book may be reproduced, stored in retrieval systems or transmitted in any form by any means, electronic, electrostatic, magnetic, mechanical photocopying, recording or otherwise, without the permission in writing from the publishers.

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“…Hems (1967) found that the data could be described by a linear nonthreshold function that predicted a tumor risk of 1 in 20 at an initial radium content of 100 µCi. Evans et al (1968), in a letter to the editor of the journal that published Hems's paper, challenged the manner in which the data had been selected from the quoted sources. Hems, for example, selected only portions of the Finkel et al (1964) data, omitting 117 cases below 0.1 µCi, where no tumors were seen.…”

Section: Risk Estimates For Radium-induced Malignanciesmentioning

confidence: 99%

Radium in humans: A review of U.S. studies

Rowland¹

1994

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The risk of bone cancer in man from internally deposited radium

Cited by 9 publications

References 7 publications

Ionizing radiation and aging: rejuvenating an old idea

Ionizing radiation and aging: rejuvenating an old idea

ICRU REPORT 96, Dosimetry-Guided Radiopharmaceutical Therapy

Radium in humans: A review of U.S. studies

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