The risk of jiggly fat in aging

Corrales, Patricia; Martín-Taboada, Marina; Medina-Gómez, Gema

doi:10.18632/aging.102147

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…As a consequence, adipocyte hypertrophy, inflammation, and fibrosis arise in SAT during the early stages of ageing before glucose tolerance is impaired and local IR progressively develops. Indeed, systemic IR will not occur before advanced ageing [24]. Altogether, these metabolic disturbances contribute to the development of T2D and other ADRs, such as CVD and NAFLD [5].…”

Section: At Aging: An Overviewmentioning

confidence: 99%

“…Several studies indicate that age reduces the replicative and adipogenic capacity of SAT APCs [12,[32][33][34][35]. Accordingly, APCs isolated from SAT of healthy elderly subjects (age > 60) display decreased proliferation and differentiation capacities relative to APCs isolated from young individuals (age [18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: At Aging: An Overviewmentioning

confidence: 99%

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Molecular basis of ageing in chronic metabolic diseases

Spinelli

Parrillo

Longo

et al. 2020

J Endocrinol Invest

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Aim Over the last decades, the shift in age distribution towards older ages and the progressive ageing which has occurred in most populations have been paralleled by a global epidemic of obesity and its related metabolic disorders, primarily, type 2 diabetes (T2D). Dysfunction of the adipose tissue (AT) is widely recognized as a significant hallmark of the ageing process that, in turn, results in systemic metabolic alterations. These include insulin resistance, accumulation of ectopic lipids and chronic inflammation, which are responsible for an elevated risk of obesity and T2D onset associated to ageing. On the other hand, obesity and T2D, the paradigms of AT dysfunction, share many physiological characteristics with the ageing process, such as an increased burden of senescent cells and epigenetic alterations. Thus, these chronic metabolic disorders may represent a state of accelerated ageing. Materials and methods A more precise explanation of the fundamental ageing mechanisms that occur in AT and a deeper understanding of their role in the interplay between accelerated ageing and AT dysfunction can be a fundamental leap towards novel therapies that address the causes, not just the symptoms, of obesity and T2D, utilizing strategies that target either senescent cells or DNA methylation. Results In this review, we summarize the current knowledge of the pathways that lead to AT dysfunction in the chronological ageing process as well as the pathophysiology of obesity and T2D, emphasizing the critical role of cellular senescence and DNA methylation. Conclusion Finally, we highlight the need for further research focused on targeting these mechanisms.

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Section: At Aging: An Overviewmentioning

confidence: 99%

Section: At Aging: An Overviewmentioning

confidence: 99%

Molecular basis of ageing in chronic metabolic diseases

Spinelli

Parrillo

Longo

et al. 2020

J Endocrinol Invest

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“…Adipose tissue increases in middle age and decreases when people get old [ 3 , 6 , 7 ], and is accompanied by fat being redistributed to different fat depots, that is, from the subcutaneous to the abdominal visceral depots [ 3 , 8 ]. There is evidence that pre-adipocytes from subcutaneous and visceral depots actually belong to different cell subtypes.…”

Section: Aging Of Adipose Tissuementioning

confidence: 99%

Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions

Wang

2022

Nutrients

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Adipose tissue is the largest and most active endocrine organ, involved in regulating energy balance, glucose and lipid homeostasis and immune function. Adipose tissue aging processes are associated with brown adipose tissue whitening, white adipose tissue redistribution and ectopic deposition, resulting in an increase in age-related inflammatory factors, which then trigger a variety of metabolic syndromes, including diabetes and hyperlipidemia. Metabolic syndrome, in turn, is associated with increased inflammatory factors, all-cause mortality and cognitive impairment. There is a growing interest in the role of nutritional interventions in adipose tissue aging. Nowadays, research has confirmed that nutritional interventions, involving caloric restriction and the use of vitamins, resveratrol and other active substances, are effective in managing adipose tissue aging’s adverse effects, such as obesity. In this review we summarized age-related physiological characteristics of adipose tissue, and focused on what nutritional interventions can do in improving the retrogradation and how they do this.

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“…Aging is associated with changes in body composition, and characterized by an increased adiposity, a topographic redistribution of adipose tissue, as well as by a decline in the functionality of this tissue 3,4 . Differences in the pattern of adiposity distribution have been described from early stages of aging 5 , mainly resulting in a redistribution of fat from subcutaneous to visceral white adipose tissue [5][6][7] . Therefore, the amount of adipose tissue is not the only factor that contributes to the development of metabolic alterations, but where it accumulates is also key to determining and preventing these alterations.…”

Section: White Adipose Tissue As One Of the Main Tissues Involved In ...mentioning

confidence: 99%

“…Overall, the lack of adipose tissue expandability, together with the resulting lipotoxicity in other metabolically relevant organs, favors the development of age-related IR and other organ-specific toxic responses leading to apoptosis 3,6,7 . A positive energy balance increases prevalence of chronic diseases like type 2 diabetes, fatty liver and cardiovascular disease, which also substantially increase in prevalence with age.…”

Section: White Adipose Tissue As One Of the Main Tissues Involved In ...mentioning

confidence: 99%