The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix

Conway, Cassandra K.; Varghese, Asha; Mahendroo, Mala; Miller, Kristin S.

doi:10.1007/s10439-021-02778-z

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…In this special issue, Grimm et al 11 presented the first review that consolidates all the published data on the forces (i.e., uterine contractions and semi-voluntary pushing) that are involved with labor and delivery. Conway et al 5 proposed the use of novel inflation-extension experiments over existing testing methods in order to evaluate the mechanical properties of the cervix in the murine model. The experiments were conducted by preserving the in vivo geometry and multiaxial loading of the organ as well as the interactions between the extracellular matrix and cells.…”

mentioning

confidence: 99%

Special Issue on the Advances in Engineering for Women’s Health

Vita

Munson

2021

Ann Biomed Eng

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mentioning

confidence: 99%

Special Issue on the Advances in Engineering for Women’s Health

Vita

Munson

2021

Ann Biomed Eng

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Smooth muscle contribution to vaginal viscoelastic response

Clark-Patterson¹,

Buchanan²,

Ogola³

et al. 2023

Journal of the Mechanical Behavior of Biomedical Materials

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Biomechanical and Compositional Changes in the Murine Uterus with Age

Domingo,

Vanoven,

De Vita

et al. 2024

Preprint

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The uterus is a hollow, fibromuscular organ involved in physiologic processes such as menstruation and pregnancy. The content and organization of extracellular matrix constituents such as fibrillar collagen dictates passive (non-contractile) biomechanical tissue function; however, how extracellular matrix composition and biomechanical function change with age in the uterus remains unknown. This study utilizes Raman spectroscopy coupled with biaxial inflation testing to investigate changes in the murine uterus with age (2-3 months, 4-6 months, 10-12 months, and 20-24 months). Linear and toe moduli significantly decreased with reproductive aging (2 to 12 months); however, moduli increased in the oldest age group (20-24 months). The optical signature of combined elastin and collagen content was significantly higher in the oldest group (20-24 month), while the glycogen contribution was the highest in the 2-3 month murine uterus. The presented workflow couples biaxial inflation testing and Raman spectroscopy, representing a critical first step to correlating biomechanics and optical signatures in the aging uterus with the potential for clinical translation. Further, this study may provide critical compositional and structure-function information regarding age-related uterine disorders.

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The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix

Cited by 4 publications

References 52 publications

Special Issue on the Advances in Engineering for Women’s Health

Special Issue on the Advances in Engineering for Women’s Health

Smooth muscle contribution to vaginal viscoelastic response

Biomechanical and Compositional Changes in the Murine Uterus with Age

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