The Role of Blood Substitutes in Emerging Healthcare Systems

Alternative strategies for emergency blood transfusion in low‐resource settings: A scoping review

“…Plasma residence times for HBOCs range from approximately 12 h for cross‐linked hemoglobin to about 2 days for polyethylene glycol (PEG)‐hemoglobin. In contrast, human red blood cells have a mean residence time of 120 days 31,32 . Even though their plasma residence times are significantly shorter than RBCs, they can be considered as a stop‐gap measure of oxygen delivery until appropriate units of RBCs are found.…”

“…Even though their plasma residence times are significantly shorter than RBCs, they can be considered as a stop‐gap measure of oxygen delivery until appropriate units of RBCs are found. Side effects of HBOCs include vasoconstriction, hypertension, gastrointestinal complaints, and jaundice with mild elevation of liver enzymes 32–34 . Levien et al also found a greater risk of myocardial infarction in patients treated with HBOCs 35 .…”

Les produits dopants de demain

“…Tout l'art serait de faire parvenir les substances au bon endroit. Certains envisagent la voie d'implants souscutanés ou de véritables petites fabriques cellulaires encapsulées dans des membranes artificielles (20) qui empêchent leur rejet par l'organisme hôte. D'autre part, on pourrait également imaginer la répara-tion de tissus abîmés par l'application in vitro de ces facteurs à des prélèvements pour permettre leur prolifération.…”

Blood substitutes: refocusing an elusive goal

“…The incidence is still high in other areas of the world, such as sub-Saharan Africa and South-east Asia. Furthermore, the cost of containing blood-borne HIV was very high and it is improbable that the measures adopted in q 2000 Blackwell Science Ltd the wealthy countries can be adopted in countries where the annual expenditure on health care is measured as a few dollars per capita per year (Winslow, 1999).…”