The Role of Bone Marrow in the Immune Response

Abdou, Nabih I.; Richter, M.

doi:10.1016/s0065-2776(08)60170-4

Cited by 42 publications

(13 citation statements)

References 362 publications

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“…Simultaneous rosetteradioautographs demonstrated that the proliferative potential of bone marrow B lymphocytes was greater than peripheral blood B lymphocytes (P < 0.01). On the other hand, the proliferative potential of bone marrow T INTRODUCTION It has been well-established in both animal species and man that the bone marrow (BM)' is the source of socalled BM-derived (B) lymphocytes (1). In the postnatal period, the BM serves as the source of stem cells which, under the influence of the thymus, can differentiate into peripheral thymus-derived (T) lymphocytes (1,2).…”

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“…On the other hand, the proliferative potential of bone marrow T INTRODUCTION It has been well-established in both animal species and man that the bone marrow (BM)' is the source of socalled BM-derived (B) lymphocytes (1). In the postnatal period, the BM serves as the source of stem cells which, under the influence of the thymus, can differentiate into peripheral thymus-derived (T) lymphocytes (1,2). Several animal studies have demonstrated that in addition to serving as a source of rapidly turning over B lymphocytes throughout life, the BM also contains a small but definite compartment of mature long-lived T lymphocytes (3,4).…”

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Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.

Fauci¹

1975

J. Clin. Invest.

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A B S T R A C T This study was undertaken to determine the proportions and in vitro immune capacities of lymphocyte populations in the bone marrows of normal humans. Relatively pure mononuclear cell suspensions were obtained from bone marrow aspirates by linear sucrose gradient centrifugations. Simultaneous peripheral blood and bone marrow specimens from each individual were assayed for lymphocyte surface markers and mitogen responsiveness. Maximal possible contamination of bone marrow aspirates by peripheral blood was determined by performing aspirates on individuals who had received 5'chromium-labeled autologous erythrocytes. Thymus-derived (T) lymphocytes, as determined by the sheep red blood cell (E) rosette assay, comprised 8.6-(±1.6) % of the total bone marrow lymphocyte pool.Bone marrow-derived (B) lymphocytes, as determined by the presence of a complement receptor, made up 15.4-(+1.9) % of the lymphocyte pool whereas 74.6(±2.4) % of mononuclear cells lacked easily detectable surface markers. These findings could not be explained by contamination with peripheral blood lymphocytes since contamination was corrected for in the calculations. Lymphocyte-enriched suspensions of bone marrow cells responded to stimulation with phytohemagglutinin, concanavalin A, and particularly pokeweed mitogen. In vitro incubations of bone marrow and peripheral blood lymphocytes with tritiated thymidine followed by determinations of E and erythrocyte antibody complement (EAC) rosettes were performed. Simultaneous rosetteradioautographs demonstrated that the proliferative potential of bone marrow B lymphocytes was greater than peripheral blood B lymphocytes (P < 0.01). On the other hand, the proliferative potential of bone marrow T

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Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.

Fauci¹

1975

J. Clin. Invest.

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“…In this regard, in addition to the BM serving as the direct source of B lymphocytes (38), it has been clearly shown that mature peripheral lymphocytes, particularly T lymphocytes can and do sequester in the BM in certain disease states (39), as well as during corticosteroid administration (40)(41)(42).…”

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Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals.

Fauci¹,

Balow²,

Pratt³

1976

J. Clin. Invest.

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A B S T R A C T This study was undertaken to determine the capability of lymphocytes in the bone marrow of normal individuals to mediate nonspecific killer cell functions in assays of phytohemagglutinin (PHA) -induced cellular cytotoxicity, and antibody-dependent cellular cytotoxicity (ADCC) against "1Cr-labeled chicken erythrocyte target cells. Relatively pure mononuclear cell suspensions were obtained from bone marrow aspirates in 30 normal volunteers by sucrose gradient centrifugations and from the peripheral blood of the same individuals by Hypaque-Ficoll density centrifugations. At an effector: target ratio of 10: 1, the PHA-induced cellular cytotoxicity of peripheral blood was 78.8±1.3%, while that of bone marrow was not significantly less at 66+9% (P > 0.1). At low effector: target ratios, the ADCC of bone marrow was negligible, while at higher effector: target ratios (20: 1) bone marrow ADCC was 69±3.7%, which was comparable to that of peripheral blood. The lymphocytes themselves in the mononuclear cell suspensions of both peripheral blood and bone marrow were capable of cytotoxic activity since depletion of monocytes from the suspensions by adherence to rayon wool and G-10 Sephadex columns did not remove the cytotoxic activity. Blocking of the Fc receptor on the effector cells by the addition of aggregated gamma globulin to the cultures suppressed the ADCC but not the PHA-induced cellular cytotoxicity of both peripheral blood and bone marrow, indicating that ADCC is dependent on an Fc receptor on the effector cell in both compartments. These studies demonstrate that the bone marrow of normal humans contains populations of lymphoid cells which have highly efficient killer cell capacities. It is uncertain what portion

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“…Any attempt to completely review all of the literature on this subject would be impossible. However, the reader is referred to several excellent reviews by Abdou and Richter (1970a), Talmage, Radovich and Hemmingsen (1970), Playfair (1971b), M iller, Basten, Sprent, andCheers (1971), Schwartz, Ryder and Gottlieb (1970), Silverman (1970) and Weigle, Chiller, and Habicht (1972). Both in vivo and in vitro studies have identified the cellular components which may cooperate in order for anti body production to occur.…”

Section: Cells Involved In the Immune Responsementioning

confidence: 99%

Comparison of the ease of tolerance induction in thymus and bone marrow of three strains of mice

Blackstock

Hyde

1973

Cellular Immunology

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The Role of Bone Marrow in the Immune Response

Cited by 42 publications

References 362 publications

Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.

Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.

Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals.

Comparison of the ease of tolerance induction in thymus and bone marrow of three strains of mice

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