The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis

Wang, Songtao; Wuu, Joanne; Savas, Louis; Patwardhan, Nilima A.; Khan, Ashraf

doi:10.1016/s0046-8177(98)90262-3

Cited by 96 publications

(90 citation statements)

References 31 publications

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“…Our previous studies have demonstrated a decreased p27 expression in both papillary and more aggressive carcinomas of the thyroid compared to their benign counterparts (22)(23)(24). We also demonstrated a similar level of cyclin D1 expression in papillary carcinoma and follicular adenoma (24). The results of these studies indicate that cyclin-dependent kinase inhibitors may have a more important role than cyclins in thyroid carcinogenesis and that they probably play a limited role in the malignant progression of thyroid cancer.…”

supporting

confidence: 72%

“…p27 negatively controls the cell transition from quiescence to proliferation by inhibiting the cyclin-CDK complexes (1). Our previous studies have demonstrated a decreased p27 expression in both papillary and more aggressive carcinomas of the thyroid compared to their benign counterparts (22)(23)(24). We also demonstrated a similar level of cyclin D1 expression in papillary carcinoma and follicular adenoma (24).…”

supporting

confidence: 65%

“…Increased expression of the cell cycle up-regulators such as cyclins or reduced expression of the cell cycle downregulators such as CDKIs may contribute to tumor formation (1-3). Our previous studies have suggested that reduced expression of p27, plays a more important role than cyclin D1 in thyroid carcinogenesis; however, p27 may have a limited role in malignant progression of thyroid cancer (22)(23)(24). To determine whether cyclin D1 overexpression was involved in thyroid malignant progression, we examined 34 cases of CPC of the thyroid, 10 cases of MIFC, and 32 cases of more aggressive carcinomas of the thyroid using immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

et al. 2000

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Cell cycle progression is facilitated by cyclindependent kinases that are activated by cyclins including cyclin D1 and inactivated by cyclindependent kinase inhibitors (CDKIs) such as p27. Our previous studies have demonstrated decreased p27 expression in both papillary and more aggressive carcinomas of the thyroid compared to thyroid adenoma and almost similar level of cyclin D1 expression between thyroid adenoma and papillary carcinoma. These results indicate that CDKIs may have an important role in the carcinogenesis of the thyroid and that they probably have a limited role in malignant progression of the thyroid cancer. The role of cyclin D1 in malignant progression of thyroid carcinoma has yet to be established. We studied the expression of cyclin D1 by immunohistochemistry in 34 cases of conventional papillary carcinoma (CPC), 10 cases of minimally invasive follicular carcinoma (MIFC), and 32 cases of more aggressive thyroid carcinoma (ATC), which included 11 tall cell variants, one columnar cell variant of papillary carcinoma, seven insular carcinomas, and 13 anaplastic carcinomas. Cyclin D1 staining was classified by staining score as 0, negative; 1؉, less than 25%; 2؉, 25 to 50%; and 3؉, more than 50% tumor cells staining positive. Kruskal-Wallis oneway ANOVA and Wilcoxon Rank Sum/MannWhitney U Test was used to assess the difference in the expression of cyclin D1 between the study groups. Twenty-eight out of the 34 CPCs were cyclin D1 positive, 24 (70%) were 1؉, 3 (9%) were 2؉, and one (3%) were 3؉ positive. Seven of 10 MIFCs were cyclin D1 positive, five (71%) were 1؉, and the remaining two (29%) were 2؉ positive. On the other hand, 28 of 32 ATCs showed cyclin D1 immunostaining. Of these, three (9%) were 1؉, five (13%) were 2؉, and 20 (63%) were 3؉ positive. This study demonstrates a significant overexpression of cyclin D1 in ATC compared CPC (P < .001) and MIFC (P < .005), suggesting that the cyclin D1 expression may play a role in tumor progression and may have prognostic significance in thyroid cancer.

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supporting

confidence: 72%

supporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

et al. 2000

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“…miR-222, miR-221, and miR-146b have been thought to play crucial roles in PTC initiation and development. The candidate targets of these miRNAs could be p27kip1, a cell cycle progression inhibitor, and KIT, a receptor tyrosine kinase that plays important roles in cell growth and differentiation [143,148]. Interestingly, high expression levels of miR-146b were found to be correlated with lower overall survival and with the development of drug resistance [149].…”

Section: Micrornasmentioning

confidence: 99%

“…There are several studies reporting overexpression of miRNAs including miR-222, miR-221, and miR-146b in PTC and these miRNAs may be of diagnostic potential [143][144][145][146][147][148][149][150][151]. In a recent study, a panel of seven miRNAs was used in thyroid FNAB samples [223].…”

Section: Molecular Targets In Histopathological Diagnosis and Classifmentioning

confidence: 99%

An update on molecular biology of thyroid cancers

Ömür

Baran

2014

Critical Reviews in Oncology/Hematology

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Underexpression of p27/Kip in Thyroid Papillary Microcarcinomas With Gross Metastatic Disease

Khoo¹,

Freeman²,

Witterick³

et al. 2002

Arch Otolaryngol Head Neck Surg

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The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis

Cited by 96 publications

References 31 publications

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

An update on molecular biology of thyroid cancers

Underexpression of p27/Kip in Thyroid Papillary Microcarcinomas With Gross Metastatic Disease

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