The pandemic has significantly affected the tourism sector worldwide; however, craftswomen are a vulnerable group that has been affected economically by this crisis. This research evaluated the level of compliance with preventive measures before and after carrying out the virtual educational intervention for craftswomen working with native cotton in the Lambayeque Region, Peru. The methodology applied was a pilot study, quasi-experimental, without a control group. The population consisted of 30 craftswomen from the populated areas of La Raya–Túcume, Pómac III-Pitipo and Jotoro-Jayanca. SPSS Statistics v25 was used for data processing. The χ2 test was used in order to evaluate the variation before and after the intervention. The correlational findings demonstrate that after applying the virtual educational intervention, it is sufficient to apply specific measures in the first (before) and second stage (during) to obtain a higher result in compliance with the general level of the regulations against COVID-19. It is concluded that the virtual educational intervention for the craftswomen has generated awareness, impacting the care of their personal health, their family and their community, as well as being prepared for the reactivation of tourism.