The Role of Cytokines in Posttraumatic Arthritis

Olson, Steven A.; Horne, Phillip H.; Furman, Bridgette D.; Huebner, Janet L.; Al-Rashid, Mamun; Kraus, Virginia B.; Guilak, Farshid

doi:10.5435/jaaos-22-01-29

Cited by 67 publications

(62 citation statements)

References 43 publications

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“…[25][26][27] To this end, data from animal studies and early clinical trials suggest that early inhibition of the intra-articular (IA) inflammatory response (e.g., 4 weeks) and posttraumatic injury of the knee may improve clinical outcomes. 28 Morisset et al reported an improvement in cartilage repair following IA injection of an adenoviral vector carrying an IL-1ra gene, 29 indicating that modulation of the joint's chemical environment may be beneficial for chondrocyte and tissue health. 30 Palliative strategies for managing joint pain include antiinflammatory analgesics such as nonsteroidal anti-inflammatory drugs alongside IA injections of glucocorticoids or hyaluronan.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

RoachBrendan

Kelmendi-DokoArta

BalutisElaine

et al. 2016

Tissue Engineering Part A

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Section: Introductionmentioning

confidence: 99%

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

RoachBrendan

Kelmendi-DokoArta

BalutisElaine

et al. 2016

Tissue Engineering Part A

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“…Despite improvements in surgical management of articular injuries, the incidence of posttraumatic OA has remained relatively unchanged over the last several decades [36]. Although the exact mechanism(s) that lead to development of posttraumatic OA remain unknown, there has been increased interest in the role of the postinjury inflammatory response leading to chondrocyte apoptosis and synovitis [32,36].…”

Section: Introductionmentioning

confidence: 99%

Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture

Haller

Swearingen

Partridge

et al. 2015

Clin Orthop Relat Res

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Background Posttraumatic osteoarthritis (OA) is a variant of OA that can develop after articular injury. Although the mechanism(s) of posttraumatic OA are uncertain, the presence and impact of postinjury proteolytic enzymes on articular cartilage remain unknown. To our knowledge, there are no studies that evaluate the presence of matrix metalloproteinases (MMPs) or aggrecan degradation after articular fracture.Questions/purposes (1) Are MMP concentrations and aggrecan degradation elevated after intraarticular fracture? (2) Are MMP concentrations and aggrecan degradation greater in high-energy injuries compared with low-energy injuries? (3) Do the concentrations of these biomarkers remain elevated at a secondary aspiration? Methods Between December 2011 and June 2013, we prospectively enrolled patients older than 18 years of age with acute tibial plateau fracture. Exclusion criteria included age older than 60 years, preexisting knee OA, injury greater than 24 hours before evaluation, contralateral knee injury, history of autoimmune disease, open fracture, and non-English-speaking patients. During the enrollment period, we enrolled 45 of the 91 (49%) tibial plateau fractures treated at our facility. Knee synovial fluid aspirations were obtained from both the injured and uninjured knees; two patients received aspirations in the emergency department and the remaining patients received aspirations in the operating room. Twenty patients who underwent spanning external fixator followed by definitive fixation were aspirated during both surgical procedures. MMP-1, -2, -3, -7, -9, -10, -12, and -13 concentrations were quantified using multiplex assays. Aggrecan degradation was quantified using sandwich enzyme-linked immunosorbent assay. Results There were higher concentrations of MMP-1 (3.89 ng/mL [95% confidence interval {CI}, 2.37-6.37] versus 0.37 ng/mL [95% CI, 0.23-0.61], p \ 0.001), MMP-3The institution of one or more of the authors (JMH, TFH) has received peer-reviewed research grant funding from the Orthopedic Trauma Association, LS Peery Foundation, and AO North America for this project. One of the authors certifies that he (TFH), or a member of his immediate family, has signed an agreement with DePuy Synthes (Warsaw, IN, USA) for consulting activities not related to the current study, and has not received payments or benefits, during the study period. One or more of the authors (CAS, KT) are employed at Eli Lilly (Indianapolis, IN, USA). All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research1 editors and board members are on file with the publication and can be viewed on request. Clinical Orthopaedics and Related Research1 neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDAapproval status, of any drug or device prior to clinical use. Each author certifies that his or her institution approved or waived approval for the reporting of this investigation and that all inves...

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“…Previous studies reported levels of Interleukin 1 and TNF-α to have reached their climax 24 hours after injury (Hui et al, 2012;Lieberthal et al, 2015). These levels remain high for weeks and even months after trauma (Catterall et al, 2010;Olson et al, 2014;Christiansen et al, 2015). Based on clinical observations, cartilage derived biomarkers increase significantly a month after knee injury (Kramer et al, 2011;Konttinen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

Sarafan¹,

Fakoor²,

Mehdinasab³

et al. 2017

GJHS

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Background and Objectives: Inflammatory processes play an important role in intra-articular fractures. The present study aimed to examine the relationship between chemerin, high-sensitivity C-reactive protein (hs-CRP), and Interleukin 17 (IL-17) serum and synovial fluid levels of osteoarthritis patients and individuals with intra-articular fractures. Method:In this case-control study, all osteoarthritis patients and individuals with intra-articular fractures who visited the Imam Khomeini Orthopedic Clinic of Ahvaz were examined. Blood samples (5 cc) were collected prior to surgery to measure chemerin Interleukin 17, and hs-CRP serum levels. Synovial fluid samples (2 cc) were collected during the surgery. Results:Measuring the levels of IL-17, chemerin and hs-CRP indicated a significant statistical difference between the serum and synovial fluids of osteoarthritis patients, individuals with intra-articular fractures, and the control group (p < .001). Post-hoc analyses showed statistically significant differences in all conditions except for hs-CRP levels between osteoarthritis patients and individuals with intra-articular fractures.Conclusion: Discovering ways to stop or slow down osteoarthritis is a matter of great concern. The findings on osteoarthritis indicate diverse, complex, and multidimensional processes involving cytokines. Information on cytokines that effect diseases can help develop efficient therapy methods.

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The Role of Cytokines in Posttraumatic Arthritis

Cited by 67 publications

References 43 publications

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

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