The role of digestive tract dysbiosis in cardiovascular continuum

Abstract

The article presents the data of scientific medical literature about the relationship of the oral cavity microbiota and gastrointestinal tract with atherogenic dyslipidemia and its role in the development of cardiovascular complications. The article shows the results of epidemiological studies of association level of inflammatory diseases in the oral cavity with atherogenic diseases of cardiovascular continuum. The mechanisms of periodontal microflora and its role in the formation of unstable atheromatous plaques in the vascular channel with possible clinical manifestations (ACS - MI, cerebral stroke) are discussed. The authors give their data of retrospective analysis 1000 outpatient’s cards of periodontitis patients of varying severity, depending on BMI and their relationship to the levels of carbohydrate\lipid metabolism, state of systemic inflammation and oxidative stress.