As the contributions in the present volume attest, we have gained a much deeper understanding of the role of perfectionism in health and well-being over the past 25 years. Advances in the theoretical conceptualizations of perfectionism, the way we measure perfectionism, and a growing appreciation of the substantial role of personality and individual difference factors in health and well-being and across different contexts have collectively converged to contribute to the development of a promising body of literature focused on understanding when, where, and why perfectionism may create risk or resilience for health and well-being. Indeed, each of the contributions in this edited volume address these important issues from novel and unique perspectives, often highlighting the commonalties of the complexities and controversies that abound. In this final chapter, we have selected four key themes emerging from these works that we believe deserve closer attention because they have the potential to pave the way for future research for the next generation of researchers in the field. Specifically, we will discuss (1) issues in the conceptualization and measurement of perfectionism, (2) the pervasiveness of perfectionism, (3) the adaptive versus maladaptive perfectionism debate, and (4) issues in measuring health and well-being in relation to perfectionism. These themes afford us new insights into links among perfectionism, health, and well-being that can guide scholars to new and exciting questions to further propel the field forward.