The role of flavonoids in autoimmune diseases: Therapeutic updates

Rengasamy, Kannan R.R.; Khan, Haroon; Gowrishankar, Shanmugaraj; Lagoa, Ricardo; Mahomoodally, Fawzi M.; Khan, Ziyad; Suroowan, Shanoo; Tewari, Devesh; Zengin, Gökhan; Hassan, Sherif T. S.; Pandian, Shunmugiah Karutha

doi:10.1016/j.pharmthera.2018.09.009

Cited by 128 publications

(72 citation statements)

References 288 publications

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“…Phytochemicals are best known to reduce the risk of chronic diseases, such as cardiovascular diseases, hypertension, diabetes, and cancers [10][11][12]. Flavonoids are the most diverse group of phytochemicals and are widely distributed in higher plants with outstanding therapeutic potential [13][14][15][16]. Flavonoids are further divided into six classes on the basis of their chemical skeleton: flavanols, flavanones, flavones, flavonols, isoflavonoids, and anthocyanidins [17].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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“…Scientific and reliable reports indicated that about 25% of prescribed medicines worldwide are taken from herbs [2]. Plant essential oils, extracts, and various kinds of secondary metabolites are known as substances with antimicrobial and antioxidant properties with little or no toxic effects, which are vital in the management of many diseases [2,3]. Actually, secondary metabolites with tremendous biological potential, known as phytochemicals, are ubiquitously present in plants and now are used as the mainstay of drug development [4].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antimicrobial/Antioxidant Activity ofCynodon dactylon(L.) Pers. Rhizome Methanolic Extract

Savadi

Vazifedoost

Didar

et al. 2020

Journal of Food Quality

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A proper use of medicinal plants requires accurate scientific information and understanding of their chemical constituents. The therapeutic effects in the plants are due to the chemical compounds therein. Cynodon dactylon (L.) Pers. of the family Poaceae is a perennial, pan-tropical species of grass which is a well-known traditional medicine and has a renowned position for treatment of many symptoms and diseases. The chemical composition, free radical scavenging activity, and antimicrobial properties of the methanolic extract of C. dactylon rhizomes against selected bacterial and fungal strains were investigated using disk-diffusion method. The results indicated that the major fatty acid structures of C. dactylon methanolic extract were palmitic acid (36.40%), oleic acid (28.26%), and linoleic acid (17.01%). Alpha-tocopherol (151.39 mg·kg−1) and sitosterol (3199.62 mg·kg−1) were the main tocopherols and sterols, respectively. According to the instrumental analysis, the total phenolic compounds of methanolic extract were equal to 917.08 mg·kg−1 and the main compound was hydroquinone (66.89%). Antioxidant activity of the methanolic extract at concentrations of 100–1000 ppm was 9.81–67.87%, which is significantly different from the 200 ppm synthetic antioxidant (BHT) with free radical scavenging activity equal to 48.93% (p<0.05). The antimicrobial study revealed that the methanolic extract of C. dactylon rhizomes was effective against all of the bacterial pathogens and the antibacterial activity increased with an increase in the concentration of extract. Therefore, the largest zone of inhibition was observed against Bacillus cereus (18.3 ± 0.4 mm) and Escherichia coli (16.8 ± 0.5 mm) at 1000 ppm. The highest resistance was observed with Pseudomonas aeruginosa (inhibition zone of 12.8 ± 0.15 mm). Methanolic extract at 200 ppm had no effect against fungus Aspergillus niger. However, at 1000 ppm concentration, an inhibition zone with a diameter of 14.4 ± 0.45 mm was formed.

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“…Most naturally occurring ingredients with consistently reported anticancer efficacy contains high levels of polyphenols (Oyenihi & Smith, 2019;Tariq et al, 2017). Polyphenols have demonstrated chemopreventive efficacy against experimental tumors, via antiinitiating, anti-promoting, anti-progression, and anti-angiogenesis actions, as well as by modulating the immune system (Asadi-Samani, Bagheri, Rafieian-Kopaei, & Shirzad, 2017;Erices, Torres, Niechi, Bernales, & Quezada, 2018;Mileo & Miccadei, 2016;Rengasamy et al, 2019;Salehi et al, 2018;Xing, Zhang, Qi, Tsao, & Mine, 2019).…”

Section: Cancermentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

611

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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The role of flavonoids in autoimmune diseases: Therapeutic updates

Cited by 128 publications

References 288 publications

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Phytochemical Analysis and Antimicrobial/Antioxidant Activity ofCynodon dactylon(L.) Pers. Rhizome Methanolic Extract

Polyphenols: A concise overview on the chemistry, occurrence, and human health

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