The role of ghrelin and serotonin in the control of eating behavior in patients with obesity and diabetes mellitus type 2

Urbanovych, Alina; Laniush, F.V.

doi:10.22141/2224-0721.16.2.2020.201300

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…5 In blood glucose control, both ghrelin and insulin secretion are involved, and it is possible that there is a negative feedback loop between the two hormones. 6 Grin is an orexigenic hormone that may activate the hunger region in the brain, causing it to become more active. 7 Because of a variety of beneficial effects on system metabolism, pharmacological targeting of the endogenous ghrelin system is generally regarded as a valuable strategy for treating metabolic issues such as chronic inflammation, gastroparesis, or cancer-associated anorexia and cachexia, among other conditions.…”

Section: Research Articlementioning

confidence: 99%

Evaluation of Serum Ghrelin Level in Patients with Type 2 Diabetes Mellitus Before and After Supplementation of 5000 IU of Vitamin D

Mohammed¹,

Hussein²

2022

IJDDT

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Background: Throughout the twenty-first century, type 2 diabetes mellitus (T2DM) has emerged as a severe worldwide public health concern, with the incidence of the disease growing on an annual basis. T2DM has been linked to abnormalities in glucose, lipid, and protein metabolism, among other things. Diabetes has been related to low vitamin D levels, as have the preventive effects of sufficient vitamin D consumption on the risk of microvascular and macrovascular problems in people with T2DM. In addition to regulating hunger, energy balance, and glucose homeostasis, ghrelin is known to be involved in many other biological functions as well. Aim of the Study: One of the goals of this study is to compare the levels of the hormone ghrelin in patients with type 2 diabetes mellitus before and after they have taken an oral vitamin D supplement of 500 IU. Patients and Methods: From January 1st to March 31st, 2021, a follow-up case study was conducted in Kirkuk Governorate. The study comprised 60 diabetes type 2 patients who were given 5000 IU of vitamin D for two months and then had their serum ghrelin levels checked before and after treatment. The SPSS application was used to examine all of the data. Results: In this study, the mean level of ghrelin was elevated significantly in type two diabetes mellitus before administered vitamin D treatment as compared with type two diabetes mellitus after administered vitamin D treatment at p-value is less than 0.01 Conclusions: It was concluded that vitamin D was an important treatment protocol in management of type two diabetes mellitus

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Section: Research Articlementioning

confidence: 99%

Evaluation of Serum Ghrelin Level in Patients with Type 2 Diabetes Mellitus Before and After Supplementation of 5000 IU of Vitamin D

Mohammed¹,

Hussein²

2022

IJDDT

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“…The prevalence of BED in DT2 individuals is up to 20% [2], whereas the prevalence of NES is 2.5 -25.6% [3]. Patients with EDs can face serious obstacles in achieving the target levels of glycemia, glycated hemoglobin (HbA1c) and lipid profile [4].…”

Section: Introductionmentioning

confidence: 99%

The role of appetite-controlling hormones in the development of eating disorders in diabetic 2 patients

Urbanovych

Laniush

2022

Current Issues in Pharmacy and Medical Sciences

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Binge eating disorder (BED) and night eating syndrome (NES) are common eating disorders (EDs) in individuals with diabetes type 2 (DT2). They worsen metabolic control, have a negative impact on physical and mental health and reduce quality of life. The roles of appetite-controlling hormones – leptin and ghrelin – is not clear enough in EDs and need to be investigated in order to establish new approaches and markers of EDs. Aim: To assess the difference in leptin and ghrelin levels in DT2 patients with and without EDs. 57 patients with DT2 were involved in the study. After physical examination and screening for EDs, blood samples for leptin and ghrelin measuring were obtained. Results: 19 participants (33.3%) were screened positively for ED (BE or NES). Leptin levels were higher in participants with ED (p<0.05). Conversely, ghrelin levels were lower in those with BE or NES (p<0.05). Leptin level is increased in DT2 individuals with BED and NES, whereas ghrelin is decreased. Leptin and ghrelin alterations maintain emotional eating, increase the frequency of binge and night eating episodes. In screening for EDs, assessing leptin and ghrelin levels will facilitate obesity reduction and improve metabolic control in diabetic patients.

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The System of Serotonin Metabolism in the Brain of Rats in the Development of Glutamateinduced Obesity and Its Correction With Nanocrystalline Cerium Dioxide

Kondro,

Vervega,

Halenova

et al. 2024

Fiziol Zh

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One of the causes of obesity is the body’s energy imbalance. The aim of our work was to investigate the serotonin system in the brain tissue of rats with glutamate-induced obesity and its correction with nanocrystalline cerium dioxide. The research was conducted on 30 white rats, divided into 3 groups of 10 animals each: 1st − intact control, 2nd − simulation of obesity by administration of monosodium glutamate to neonatal animals, 3rd − correction of obesity using nanocrystalline cerium dioxide against the background of neonatal administration of monosodium glutamate. To confirm the presence of obesity, at 4 months of age, rats were weighed, naso-anal length was measured, and Lee’s index was calculated. It was found that rats after neonatal administration of monosodium glutamate developed obesity, and the content of serotonin in the brain decreased by 72.9% compared to the control. The content of tryptophan, a precursor in the synthesis of serotonin, in rats with glutamate-induced obesity was 93.3% lower compared to controls. Tryptophan hydroxylase activity in the brain of rats with glutamate-induced obesity tended to decrease, and tryptophan decarboxylase activity increased by 65.9% compared to the controls. The activity of monoamine oxidase in the brain of rats after neonatal administration of monosodium glutamate increased by 41.7% compared to the control, which indicates enhanced degradation of serotonin. Indoleamine-2,3-dehydrogenase activity in the brain of rats with glutamate-induced obesity increased by 122.2%, this evidences activation of the alternative kynurenine pathway of tryptophan metabolism in the brain. This may also be one of the reasons for the reduced serotonin content in the brains of rats with glutamate-induced obesity. Periodic administration of nanocrystalline cerium dioxide to rats after neonatal sodium glutamate administration prevented obesity and led to an increase in serotonin and tryptophan content in the brain by 171.6% and 72.7%, respectively, a decrease in tryptophan decarboxylase activity by 15.1%, an increase in monoamine oxidase activity by 60.7% and a decrease in indoleamine2,3-dihydrogenase activity by 17.7% compared to rats after neonatal sodium glutamate administration. We conclude that the serotonin system is involved in the development of glutamate-induced obesity, and that periodic administration of nanocrystalline cerium dioxide significantly improves serotonin metabolism parameters.

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The role of ghrelin and serotonin in the control of eating behavior in patients with obesity and diabetes mellitus type 2

Cited by 5 publications

References 43 publications

Evaluation of Serum Ghrelin Level in Patients with Type 2 Diabetes Mellitus Before and After Supplementation of 5000 IU of Vitamin D

Evaluation of Serum Ghrelin Level in Patients with Type 2 Diabetes Mellitus Before and After Supplementation of 5000 IU of Vitamin D

The role of appetite-controlling hormones in the development of eating disorders in diabetic 2 patients

The System of Serotonin Metabolism in the Brain of Rats in the Development of Glutamateinduced Obesity and Its Correction With Nanocrystalline Cerium Dioxide

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