The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: A case–control study in a Turkish population

Gönül, Nüvit; Kadıoğlu, Ela; Kocabaş, Neslihan Aygün; Özkaya, Mesut; Karakaya, Ali Esat; Karahalıl, Bensu

doi:10.1016/j.gene.2012.05.025

Cited by 47 publications

(35 citation statements)

References 16 publications

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“…34 In contrast, several studies have reported a significant association between the frequency of GSTM1 null and GSTT1 null genotypes and T2DM. 7,30,33 In a Turkish study, 16 the GSTM1 null genotype had a higher genotype frequency in T2DM patients than in a control group and was associated with a 3-fold increased risk of T2DM (OR = 3.7, 95% CI = 2.5-6.70; P < .05). In a South Indian population, 35 a 2-fold risk of T2DM was seen for patients with the GSTM1 null genotype (OR = 2.93, 95% CI = 2.08-4.12; P < .001), and a 3-fold increased risk was associated with the GSTT1 null genotype (OR = 3.11, 95% CI = 2.18-4.46; P < .001).…”

Section: Discussionmentioning

confidence: 93%

“…Our results were in accordance with data obtained from studies with statistically varied parameters. 15,16,20,33 For example, Stoian and colleagues (2015) reported no significant association between the GSTM1 and GSTT1 null genotypes and the development of type 2 diabetes mellitus (T2DM) in a Romanian patient population compared with a healthy control group (P = .96 for GSTM1; P = .21 for GSTT1). 23 Porojan and colleagues (2015) likewise found no increased frequency of the GSTM1 and GSTT1 null genotypes in the T2DM group compared with healthy controls (for GSTM1, OR = 1.44, CI = 0.85-2.45; P = .171; for GSTT1, OR = 0.85, CI = 0.44-1.67; P = .647).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Yalin and associates (2007) and Gönül and colleagues (2012) demonstrated the lack of any association between GSTP1 genotype polymorphisms and T2DM in Turkish patients. 16,33 We also evaluated the relation between genetic polymorphisms of GSTs and the risk of developing NODM in NODM and non-NODM liver transplant recipients. Our results showed a statistically significant association between GSTP1 genotypes and the risk of NODM development, whereas no significant correlation was found between GSTM1 and GSTT1 null genotypes and the risk of NODM development.…”

Section: Discussionmentioning

confidence: 99%

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Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Musavi

Moasser²,

Zareei³

et al. 2019

Exp Clin Transplant

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Objectives: The association between the glutathione Stransferase polymorphisms and the development of new-onset diabetes mellitus after liver transplant was studied. Materials and Methods: Peripheral blood samples were collected from 106 liver transplant patients divided into 2 groups: 52 with new-onset diabetes mellitus and 54 without new-onset diabetes mellitus; 169 healthy individuals with no clinical evidence of diabetes mellitus were selected as a control group. The multiplex polymerase chain reaction technique was used for genotyping GSTM1 and GSTT1 genes, using the cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene as an internal control. The genotype of GSTP1 was determined using the restriction fragment length polymorphism-polymerase chain reaction technique. Results: The frequency of both GSTM1 null and GSTT1 null genotypes was not significantly different in liver transplant patients with new-onset diabetes mellitus compared with the control group (P = .11 for GSTM1; P = .71 for GSTT1). Also, there was no statistically significant association between the frequency of the GSTP1 genotypes in the liver transplant patients with new-onset diabetes mellitus compared with controls. Neither GSTM1 nor GSTT1 null genotypes were associated with the risk of developing new-onset diabetes mellitus (P = .22 for GSTM1; P = .56 for GSTT1). However, the frequency of the heterozygous mutation (AG) in the A313G GSTP1 polymorphism in patients with new-onset diabetes mellitus was significantly higher than in patients without new-onset diabetes mellitus (55.8% vs 7.4%; P = .00). Thus, the risk of developing new-onset diabetes mellitus was significantly higher in patients presenting with heterozygous GSTP1 genotypes (odds ratio = 15.76; 95% confidence interval = 4.53-60.28; P = .00). Conclusions: The GSTP1 AG genotype was associated with an increased susceptibility to the development of new-onset diabetes mellitus after liver transplant.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Musavi

Moasser²,

Zareei³

et al. 2019

Exp Clin Transplant

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“…There was, for example, only one report from China [3], one from Western Europe [2] and no reports from America. Also, there was no data in the published articles regarding their control sources [5,6,[9][10][11]. Finally, the majority of the studies included in the meta-analysis, presented no data related to the life-style of the participants.…”

mentioning

confidence: 99%

“…If Zhang et al, [1] concerning the association between susceptibility to type II DM and polymorphisms of GSTT1 and GSTM1 [2][3][4][5][6][7][8][9][10][11]. A list of these studies in Table 1.…”

mentioning

confidence: 99%

Null genotypes of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms increased susceptibility to type 2 diabetes mellitus, a meta-analysis

Saadat

2013

Gene

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GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations

Karaca

Cesuroğlu

et al. 2014

American J Hum Biol

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The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: A case–control study in a Turkish population

Cited by 47 publications

References 16 publications

Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Null genotypes of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms increased susceptibility to type 2 diabetes mellitus, a meta-analysis

GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations

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