The Role of Human Metapneumovirus in Upper Respiratory Tract Infections in Children: A 20‐Year Experience

Williams, John V.; Wang, Chiaoyin K.; Yang, Chin-Fen; Tollefson, Sharon J.; House, Frances S.; Heck, Josh M.; Marla, Chu; Brown, Jennifer B.; Lintao, Linda D.; Quinto, Joe D.; Chu, David C. K.; Spaete, Richard R.; Edwards, Kathryn M.; Wright, Peter F.; Crowe, James E.

doi:10.1086/499274

Cited by 230 publications

(255 citation statements)

References 38 publications

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

“…Numerous studies have focused on the clinical and epidemiological characteristics of HMPV infection, but few have been population based, and consequently the available information on the incidence and burden of this disease remains scarce. In addition, few studies have been conducted over several years, which is essential to adequately evaluate incidence rates, given that the intensity of HMPV circulation may vary considerably in distinct seasons [8][9][10]. The main aim of this study was to accurately estimate the incidence rates of hospitalization for community-acquired HMPV infection in an unselected and well-defined population of infants and children aged <3 years from an area of northern Spain.…”

Section: Introductionmentioning

confidence: 99%

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Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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“…Like RSV, hMPV infects humans of all ages but causes more severe disease in infants, the elderly and the immunocompromised [3,6,9,17,25,26]. Like hRSV, hMPV can re-infect throughout life [29], although essentially all children have had a first infection by age 5. Its ability to co-infect with other respiratory infectious agents, including RSV and pneumococci [14,27], combined with its relatively slow replication in cell culture likely accounted for its ability to escape isolation until 2001.…”

Section: Introductionmentioning

confidence: 99%

Human metapneumovirus: Enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged

Yim¹,

Cragin²,

Boukhvalova³

et al. 2007

Vaccine

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Cotton rats (Sigmodon hispidus) are susceptible to the recently discovered human metapneumovirus (hMPV), an agent closely related to human respiratory syncytial virus. Since certain respiratory syncytial virus vaccines can induce enhanced disease upon viral challenge, we have done similar experiments with hMPV in cotton rats. Young adult cotton rats were vaccinated with a formalininactivated preparation of hMPV strain C-85473, or with a mock preparation of the vaccine on day 0 and again on day 28. All animals were challenged intranasally on day 49 with 10 7 TCID 50 of the same hMPV strain. Animals were sacrificed on days 4, 7, and 10 post-challenge and lungs were removed for viral quantitation, histopathology, and cytokine mRNA expression analysis (interferongamma (IFN-γ) and interleukin-4 (IL-4)). Although the vaccinated animals showed almost complete protection from viral replication in the lungs (<10 2.0 TCID 50 per gram), there was a dramatic increase in the lung pathology, particularly the interstitial pneumonitis and alveolitis with elevated serum neutralizing antibody titer prior to challenge. Cytokine profiles were distinctive from those observed during primary infection and re-infection. The data raise safety concerns for hMPV vaccine preparations.

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“…Se describen brotes por este agente a fines del invierno y comienzos de la primavera, los que se prolongan hasta después de finalizar el brote de VRS 29 . Nuestro caso fue hospitalizado en noviembre del año 2005, fecha en que no había circulación de VRS en Santiago, Chile.…”

Section: Discussionunclassified

“…La inmunidad no es duradera, por lo que puede haber re-infecciones posteriores 31 . Puede ocasionar entre 2 y 18% de las IRAB que se hospitalizan [32][33][34][35] y 12% de las consultas ambulatorias 29 . Síntomas acompañantes descritos son: tos (en 90% de los casos), rinorrea (75%), signología obstructiva (57%), fiebre (50%), vómitos (41%), irritabilidad (37%), OMA (33%), disfagia (31%), laringitis obstructiva (8-14%), diarrea (6-35%), exantema (11%), y conjuntivitis (3-18%) [36][37][38][39][40][41] .…”

Section: Discussionunclassified

Apnea como forma de presentación de una infección por metapneumovirus humano

et al. 2007

Rev. chil. infectol.

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Apnea as a presenting symptom in human metapneumovirus infectionHuman metapneumovirus (hMPV), a recently described pathogen of lower respiratory tract infections (LRTI), has been detected in 5,4% of Chilean infants hospitalized for LRTI whom are negative for adenovirus, respiratory syncytial virus, influenza and parainfluenza viruses. hMPV may cause bronchiolitis or pneumonia in hospitalized patients, and ocassionally require admission to intensive care units and mechanical ventilation. The infection has been associated with apnea, especially in preterm infants. Nosocomial dissemination has also been described. We present the case of a one-month-of age premature infant with apnea, and infection caused by hMPV of probable nosocomial aquisition. Clinical features of hMPV infection are reviewed and its association with apnea and nosocomial transmission is discussed. hMPV should be included in the routine diagnosis of respiratory viruses in infants with apnea and should be considered among the respiratory pathogens associated with nosocomial transmission.

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The Role of Human Metapneumovirus in Upper Respiratory Tract Infections in Children: A 20‐Year Experience

Abstract: hMPV was detected in a substantial number of children with URIs and concomitant AOM.

Cited by 230 publications

References 38 publications

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Human metapneumovirus: Enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged

Apnea como forma de presentación de una infección por metapneumovirus humano

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