The role of IgE in the immune response to neoplasia: a review

Rosenbaum, Jeremy; Swyer, J M

doi:10.1097/00006534-197711000-00128

Cited by 8 publications

(10 citation statements)

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“…The underlying mechanisms of the potential role of atopy in the risk of lymphoma are unclear. T cells are recognized as having a central role in the immune response to neoplasia as well as in the production and regulation of IgE (18). Both HL and NHL have been found to be associated with a T helper 2 dominant lymphocyte response (19,20) similar to what has been shown in atopic subjects.…”

Section: Introductionmentioning

confidence: 90%

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic studies have shown an inverse association between atopy and malignant lymphoma, but results are inconsistent. We investigated levels of IgE, before and after commencement of treatment, and evaluated lymphoma risk in relation to total and specific IgE levels. Serum levels of IgM, IgA, and IgG were also measured. We enrolled 467 newly diagnosed lymphoma cases and 544 hospital controls, matched for age, sex, and hospital. Lymphomas were histologically confirmed and categorized according to the WHO classification. Subjects provided blood for analysis of total and specific IgE levels, and total IgM, IgA, and IgG levels. Additional information was collected by intervieweradministered questionnaire. Controlling for age, sex, center, smoking status, and any treated asthma or eczema, we found that the overall risk of lymphoma was significantly lower in the high [odds ratio (OR), 0.39; 95% confidence interval (95% CI), 0.28-0.54] and middle (OR, 0.55; 95% CI, 0.40-0.74) tertiles for total serum IgE compared with the low tertile. Specific IgE to common aeroallergens (defined as z0.35 kU/L) was also inversely associated with risk of lymphoma (OR, 0.67; 95% CI, 0.45-1.00). Lymphoma was associated with IgA and IgM but not IgG. Mean levels of all immunoglobulins were decreased with more advanced malignancy, and total serum IgE levels were lower before treatment. The data suggest that the low levels of immunoglobulins seen in a wide range of lymphoma cases is likely to be linked to a lymphogenesis process rather than resulting from a selective protection due to an atopic process. Long-term cohort studies may be fundamental to fully evaluate these associations. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1492 -8)

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Section: Introductionmentioning

confidence: 90%

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…There is also evidence that cell mediated immunity, including T-cells, is of importance in immunity to viruses causing respiratory infections (Ganguly & Waldman, 1982) and meningitis (Welliver et al, 1982). The T-cell is though to play a central role in the immune response to neoplasia (Rosenbaum & Dwyer, 1977), and epidemiological evidence suggests (Kinlen, 1982) that immunological factors are important in the development of some but not most cancers in man. Testis cancer has in common with several of these tumours that it does not increase steeply in incidence with age.…”

Section: Opel Ation1smentioning

confidence: 99%

Testicular cancer and antecedent diseases

Swerdlow¹,

Huttly²,

Smith³

1987

Br J Cancer

106

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Summary A case-control study of the aetiology of testicular cancer was conducted using information obtained by interview and from case-notes of 259 cases with testicular cancer and two sets of control patients -238 men with diagnoses other than testicular cancer attending the same radiotherapy centres as those attended by the cases, and 251 hospital in-patients not attending radiotherapy departments. Logistic regrcssion analyses were performed, after stratifying by age and region of residence, to estimate the relative risks (RRs) associated with various aspects of prior medical history. The risk of testicular cancer was found to be raised for men with a history of cryptorchidism (RR based on comparison with all controls =6.3; P<0.001), inguinal hernia (RR= 1.6; P=0.14), mumps orchitis (RR= 12.7; P=0.006), atopy (RR= 1.8; P=0.03), and meningitis (RR=3.0; P=0.21). Inguinal herniorrhaphy before the age of 15 years was particularly a risk factor for seminoma, whereas the relative risks were similar for seminoma and teratoma for the other factors. The results add to the growing evidence that congenital abnormalities involving the process of testicular descent and closure of the processus vaginalis are risk factors for testicular cancer, and that some types of testicular damage later in life may also be important. The findings of associations with previous atopy and certain infections suggest a possible second aetiological mechanism -that immunological abnormalities may be associated with an increased risk of testis cancer.Testicular cancer is one of the commonest cancers in young men and is increasing in incidence in adults in many white populations, but its aetiology remains largely unknown. There is growing evidence of an aetiological role for prenatal factors (Henderson et al., 1979;Loughlin et al., 1980;Schottenfeld et al., 1980;Depue et al., 1983), and testis cancer is associated with some congenital malformations involving abnormalities of genito-urinary tract development. Associations have been shown with cryptorchidism, which is found in about 10% of eases (Morrison, 1976;Henderson et al., 1979;Schottenfeld et al., 1980;Depue et al., 1983;Mills et al., 1984;Pottern et al., 1985), inguinal hernia (Li & Fraumeni, 1972;Morrison, 1976;Swerdlow et al., 1982;Depue et al., 1983) and, for childhood testicular cancer, congenital genito-urinary abnormalities other than cryptorchidism (Li and Fraumeni, 1972;Sakashita et al., 1980;Swerdlow et al., 1982). Adult, but not childhood, testicular cancer incidence has increased in white populations in recent years which suggests that postnatal factors may also be important in the aetiology of the adult disease. Mumps orchitis appears to be an uncommon postnatal cause of the tumour (Beard et al., 1977a; Lin and Kessler, 1979), but there has been little investigation of postnatal disease associations.The present study examined associations between various previous diseases and testicular cancer in data collected in a case-control study conducted in the environs of Oxford and the ...

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“…Early studies purported to show that the incidence of atopy was decreased in cancer patients (Fisherman, 1960;Mackay, 1966) but subsequent large controlled studies were unable to verify the earlier claims (McKee et al, 1967;Shapiro et al, 1971) and the consensus of opinion now is that the presence of atopy does not protect against oncogenesis (for review, see Rosenbaum & Dwyer, 1977). However none of these studies examined how atopic cancer patients fared compared to their non-atopic counterparts.…”

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confidence: 99%