The role of IL-1 gene polymorphisms ( IL1A , IL1B , and IL1RN ) as a risk factor in unsuccessful implants retaining overdentures

Fernandes, Margarida Sampaio; Braga, Ana Cristina; Sampaio-Fernandes, J.C.; Figueiral, Maria Helena

doi:10.1016/j.jpor.2017.01.004

Cited by 9 publications

(18 citation statements)

References 70 publications

(151 reference statements)

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“…As shown by the flow diagram of literature search ( Fig 1 ), a total of 27 studies with 1324 cases and 1808 controls were finally included in meta-analysis [ 22 – 24 , 26 – 49 ]. There were 10, 3 and 13 studies recruiting patients with IF/IL, MBL and PI, respectively, while Fernandes et al [ 29 ] enrolled participants with various peri-implant disease. Six studies included participants of Asian ancestry while the others included subjects of Caucasian ancestry.…”

Section: Resultsmentioning

confidence: 99%

“…The sample size ranged from 28 to 369. As to smoking status, 3 studies reported higher smoking rates in peri-implantitis group than healthy implant group [ 28 , 43 , 47 ], 7 enrolled participants matched for smoking status [ 27 , 32 , 33 , 36 , 39 , 40 , 45 ], 9 were performed in non-smokers [ 24 , 26 , 31 , 35 , 37 , 38 , 41 , 44 , 48 ] and 1 in smokers [ 30 ], whereas 7 did not report the smoking status [ 22 , 23 , 29 , 34 , 42 , 46 , 49 ]. IL-1α C-889T polymorphism was investigated in 10 studies, IL-1β C+3954T in 14 studies, IL-1β C-511T in 8 studies, TNFα G-308A in 12 studies, and composite genotype of IL-1α C-889T and IL-1β C+3954T in 7 studies.…”

Section: Resultsmentioning

confidence: 99%

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Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

2021

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Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers. Conclusion Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

2021

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“…The literature supports the evidence that SNPs play an important role in the transcription of these inflammatory mediators and may influence the osseointegration success, including single‐nucleotide polymorphism (SNPs) in MMPs …”

Section: Discussionmentioning

confidence: 57%

“…Some single‐nucleotide polymorphism (SNPs) may affect gene expression levels and protein production or functions; consequently, they influence osteogenesis and inflammatory responses. Some SNPs in cytokines and lipid mediators genes were associated with implant loss and peri‐implantitis, explain some of interindividual risk factors …”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Munhoz

Branco²,

Souza

et al. 2018

Clin Implant Dent Rel Res

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Background Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix. Purpose This case‐control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss. Materials and Methods Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR‐RFLP. Results A significant association of rs1799750 (MMP‐1) and rs11225395 (MMP‐8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P < 0.0001). Haplotype T‐A‐GG‐5A‐C had a statistically significant risk effect, while haplotype C‐A‐G‐6A‐C andT‐G‐2G‐5A‐C had a protective effect in implant loss. Conclusions The results of this study showed that MMPs haplotype are a risk factor to early implant loss.

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“…Another limitation of our study was that it was focused only on single dental implant survival. Articles focused on implants retaining overdentures such as the study by Fernandez et al56 were not included to ensure sample homogeneity and due to a different role that the implant overload factors may play in these cases.…”

Section: Discussionmentioning

confidence: 99%

<p>The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review</p>

Zhang

Finkelstein²

2019

CCIDE

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Objectives The purpose of this review was to evaluate the relationship between genetic polymorphisms and dental implant loss. Materials and methods All case-control studies examining single nucleotide polymorphisms (SNPs) and dental implant failure were considered. A Boolean search was conducted on PubMed and Scopus to find eligible studies. Results The initial search produced 78 results. Twenty-one studies were considered for inclusion after review and 16 were included in the final review. Twenty-two different polymorphisms were analyzed and statistically significant correlation was found for IL-4, IL-1A, IL-1B, MMP-8, and MMP-1 polymorphisms for dental implant failure. Discussion A limited number of comprehensive studies have been done in this field. Additional studies with larger sample sizes and different ethnic backgrounds need to be done to see if the results can be reproduced. Of the polymorphisms studied, the IL-4 (+33), MMP-8 (−799), MMP-1 (−519), and MMP-1 (−1607) polymorphisms show the greatest association with dental implant loss.

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The role of IL-1 gene polymorphisms ( IL1A , IL1B , and IL1RN ) as a risk factor in unsuccessful implants retaining overdentures

Abstract: The prediction model developed in this study could serve as a basis for further improved models that would assist clinicians in the daily diagnosis and treatment planning practice of oral rehabilitation with implant overdentures.

Cited by 9 publications

References 70 publications

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

<p>The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review</p>

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