The role of IL-29 in immunity and cancer

Kelm, Noah E.; Zhu, Ziwen; Ding, Vivi A.; Xiao, Hualiang; Wakefield, Mark R.; Bai, Qian; Fang, Yujiang

doi:10.1016/j.critrevonc.2016.08.002

Cited by 35 publications

(30 citation statements)

References 106 publications

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“…Interferons (IFN-α, IFN-β, IFN-γ, IL-28, IL-29) are cytokines with antiviral activity and their expression is induced by viral infection. IL-28 and IL-29 are members of IFN-λ family [12,13]. They are produced by dendritic…”

Section: Discussionmentioning

confidence: 99%

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

Mikola

Elenius

Saarinen

et al. 2018

Clin Transl Allergy

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BackgroundTonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis.MethodsTonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed. Patients were carefully characterized clinically. Standard questionnaire was used to asses preceding and allergy symptoms. Respiratory viruses were analysed in tonsils and nasopharynx by PCR. Quantitative real-time PCR was used to analyse intratonsillar gene expressions of IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2 and Tbet.ResultsMedian age of the subjects was 15 years (range 2–60). Patients with tonsillar hypertrophy were younger, smoked less often, had less pollen allergy and had more adenovirus, bocavirus-1, coronavirus and rhinovirus in nasopharynx (all P < 0.05). Only bocavirus-1 was more often detected in hypertrophic tonsils (P < 0.05). In age-adjusted analysis, tonsillar hypertrophy was associated with higher mRNA expressions of IL-37 (P < 0.05).ConclusionsIntratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independently associated with tonsillar hypertrophy showing slightly stronger anti-inflammatory response in these patients.Electronic supplementary materialThe online version of this article (10.1186/s13601-018-0205-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

Mikola

Elenius

Saarinen

et al. 2018

Clin Transl Allergy

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“…IL-29 has an antitumor effect in several cancers including lung cancer, esophageal carcinomas, and colorectal cancer. 26 In addition to its antiviral and antitumor activities, IL-29 acts as an immune modulator in rheumatoid arthritis and allergic asthma. 27,28 However, little is known about the function of IL-29 in metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

IL-29 promoted obesity-induced inflammation and insulin resistance

et al. 2019

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Adipocyte-macrophage crosstalk plays a critical role to regulate adipose tissue microenvironment and cause chronic inflammation in the pathogenesis of obesity. Interleukin-29 (IL-29), a member of type 3 interferon family, plays a role in host defenses against microbes, however, little is known about its role in metabolic disorders. We explored the function of IL-29 in the pathogenesis of obesity-induced inflammation and insulin resistance. We found that serum IL-29 level was significantly higher in obese patients. IL-29 upregulated IL-1β, IL-8, and monocyte chemoattractant protein-1 (MCP-1) expression and decreased glucose uptake and insulin sensitivity in human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes through reducing glucose transporter 4 (GLUT4) and AKT signals. In addition, IL-29 promoted monocyte/macrophage migration. Inhibition of IL-29 could reduce inflammatory cytokine production in macrophage-adipocyte coculture system, which mimic an obese microenvironment. In vivo, IL-29 reduced insulin sensitivity and increased the number of peritoneal macrophages in high-fat diet (HFD)-induced obese mice. IL-29 increased M1/M2 macrophage ratio and enhanced MCP-1 expression in adipose tissues of HFD mice. Therefore, we have identified a critical role of IL-29 in obesity-induced inflammation and insulin resistance, and we conclude that IL-29 may be a novel candidate target for treating obesity and insulin resistance in patients with metabolic disorders.

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“…In most types of cancer, IL29 typically has antitumor effects, but in multiple myeloma B, IL29 produces tumor-promoting effects. Thus, more research is needed to investigate and elucidate the relationship of IL29 with cancer (25). It is interesting to see that the levels of IL29 autoantibodies in the present breast cancer study, as well as the previous ovarian cancer study (8) were elevated in the test groups compared to the reference groups (Table I).…”

Section: Discussionmentioning

confidence: 54%