The Role of Insulin-Like Growth Factor Binding Proteins in Development

Molecular characterization and expression patterns of insulin-like growth factor-binding protein genes in postnatal Nanjiang brown goats

“…Studies on IGFBPs roles in tissue development have shown that IGFBPs play critical roles in mammalian growth and development (Peng et al, 1996;Gerrard et al, 1999;Pell et al, 2005;Farin et al, 2010). In our study, three IGFBP mRNA expression patterns were observed across time during postnatal liver development: "up-down" (IGFBP-1, -2 and -5), "down-up" (IGFBP-3 and -4), and fluctuating "up-down" (IGFBP-6) expression.…”

The Insulin-like Growth Factor-1 Axis and its Potential as a Therapeutic Target in Central Nervous System (CNS) Disorders

“…To add to the complexity of this system, a larger glycoprotein called the acid-labile subunit also attaches to IGFBP-3 and -5 in circulation. Due to the sequestration of IGF-1 from its receptor, the concentration at which IGF-1 is found in circulation or in tissues is much greater than the concentration required to achieve full activation of the IGF-IR (100 nM in circulation and 30 nM in tissues versus 1-2 nM needed to activate the IGF-IR at the cellular level) [32,33]. The pool of IGF-1 is therefore quite important.…”

Role of Connective Tissue Growth Factor (CTGF/CCN2) in Oral Squamous Cell Carcinoma-Induced Bone Destruction

“…Activation of IGF-I/IGFR signaling plays an important role in cancer cells, leading to an increase in cell proliferation, invasion/migration, to a decrease in apoptosis, and to resistance to antineoplastic agents, suggesting that IGF/IGFR plays an important role in mammary tumorigenesis (Brady, et al, 2007;Kimura, et al, 2010;Saxena, et al, 2008). A larger family of secreted cysteine-rich proteins, made so by inclusion of the Twisted gastrulation (TSG), IGFBP, and CCN families, is termed TIC (Flint, et al, 2008;Pell, et al, 2005). Interestingly, members of the CCN protein family bind IGF with low affinity (Hwa, et al, 1999).…”