The role of interleukin-12, and tissue antioxidants in chronic sinusitis

Kassim, Samar K.; Elbeigermy, Mohammed; Nasr, Gehan F; Khalil, Rasha; Nassar, Mohammed Kamal

doi:10.1016/s0009-9120(02)00313-2

Cited by 13 publications

(13 citation statements)

References 19 publications

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“…The present results indicate that increasing levels of oxidative stress markers in does with gangrenous mastitis might have an essential role in the process of inflammation and tissue damage. Uric acid is the major low molecular weight intracellular antioxidant in upper respiratory fluids (Kassim et al, 2002). Similarly, our results showed a significant increase in the level of uric acid in diseased does compared to the healthy ones.…”

Section: Discussionsupporting

confidence: 82%

Clinicobiochemical investigations of gangrenous mastitis in does: immunological responses and oxidative stress biomarkers

El-Deeb

2013

J. Zhejiang Univ. Sci. B

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Abstract:A total of 50 does were used to determine selected hematological and biochemical parameters with special references to oxidative stress markers, acute phase protein profiles, and proinflammatory cytokines in healthy and gangrenous mastitis affected does. Animals were divided into two equal groups represented as clinically healthy (control) and diseased groups, respectively. The bacteriological examination of milk samples from diseased does revealed many types of bacterial infection. The isolated bacteria were Staphylococcus aureus (N=23/25), Escherichia coli (N=11/25), and Clostridium perfringens (N=4/25). There was a significant increase in the levels of β-hydroxybutyrate, non-esterified free fatty acids, triglyceride, low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase, and alanine aminotransferase and a significant reduction in the levels of glucose, cholesterol, and high density lipoprotein cholesterol (HDL-C) in does with gangrenous mastitis compared to healthy does. Moreover, there was a significant increase in the levels of malondialdehyde and uric acid with a significant decrease in the levels of reduced glutathione, super oxide dismutase, and catalase in does with gangrenous mastitis compared to healthy does. In addition, there was a significant increase in the haptoglobin, serum amyloid A, fibrinogen, interleukin 6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in does with gangrenous mastitis compared to healthy ones. Conclusively, oxidative stress biomarkers, acute phase proteins, and proinflammatory cytokines play an essential task as biomarkers for gangrenous mastitis in does. Mastitis may be considered as one of the ketotic stressors in does after parturition.

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Section: Discussionsupporting

confidence: 82%

Clinicobiochemical investigations of gangrenous mastitis in does: immunological responses and oxidative stress biomarkers

El-Deeb

2013

J. Zhejiang Univ. Sci. B

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“…On the contrary, Kassim et al reported a significant decrease in tissue vitamin E in the patients group [5]. In the present study, we have found a significant decrease in serum levels of vitamin E and C in the patients, but vitamin A levels did not differ.…”

Section: Discussioncontrasting

confidence: 87%

“…However, Kassim et al did not find such a relation between reduced glutathione and uric acid levels and chronic rhinosinusitis, but they showed a low superoxide dismutase activity in patients with chronic rhinosinusitis [5]. They concluded that this low activity may be due to a possible Zn deficiency in these patients.…”

Section: Discussionmentioning

confidence: 94%

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Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis

Ünal

Tamer

Pata

et al. 2004

Journal of Trace Elements in Medicine and Biology

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“…A number of studies in the medical literature have reported increased levels of a variety of inflammatory cytokines in the sinonasal mucosa of patients with sinusitis. [7][8][9][10][11] Treatment with intravenous corticosteroids has been shown to decrease levels of some of these inflammatory cytokines and therefore facilitate the treatment of acute and chronic sinusitis. [12][13][14] Intravenous steroids have also been shown to decrease mucosal edema, potentially helping with sinus drainage.…”

mentioning

confidence: 99%

Effect of Corticosteroids in the Acute Management of Pediatric Orbital Cellulitis With Subperiosteal Abscess

Yen¹,

Yen²

2005

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose:To determine the effect of intravenous corticosteroids in the acute management of pediatric orbital cellulitis with subperiosteal abscess.Methods: The inpatient records of all patients treated for orbital cellulitis with subperiosteal orbital abscess between January 2001 and August 2003 were reviewed. The use of corticosteroids, length of hospital stay, need for surgical drainage, treatment course, and clinical outcomes were reviewed. A t test and Fisher exact test analysis were calculated to evaluate statistical significance.

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The role of interleukin-12, and tissue antioxidants in chronic sinusitis

Cited by 13 publications

References 19 publications

Clinicobiochemical investigations of gangrenous mastitis in does: immunological responses and oxidative stress biomarkers

Clinicobiochemical investigations of gangrenous mastitis in does: immunological responses and oxidative stress biomarkers

Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis

Effect of Corticosteroids in the Acute Management of Pediatric Orbital Cellulitis With Subperiosteal Abscess

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