The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles

The intensity of internalization and cytotoxicity of superparamagnetic iron oxide nanoparticles with different surface modifications in human tumor and diploid lung cells

“…Less efficient MNPs uptake was observed at 10% FCS than at 2% FCS in culture medium. In line with our results, a larger amount of maghemite nanoparticles has been observed inside HeLa cells at 1% FCS than at 10% FCS in culture medium [34]. These data indicated that MNPs internalization might affect also the ratio between the serum proteins and the amount of nanoparticles.…”

Magnetic nanovectors for drug delivery

“…Considered to be hi ghly favo rab le co nditi ons Considered to be mode rate ly favorab le co nditi ons Considered to be poo rly fa vorab le con ditions Not considered developed in this context The iron redox state of USPION (ultrafine SPIO nanoparticles) was found to markedly affect their cellular uptake and subsequent induction of DNA damage [114]. The generation of Fe ions, chromosomal damage due to DNA fragmentation, and accumulation of oxidized DNA bases lesions, supported a mechanism of oxidative DNA damage by ␥-Fe 2 O 3 dextran-coated USPION.…”

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

“…The degree of surface coverage has been postulated to be the main parameter in cellular Although dextran is a complex branched glucose that is often used in medical applications, dextran coated magnetite particles caused cell death as much as uncoated magnetite particles (Berry et al, 2003). Conversely, in a comparative study, uncoated magnetite, uncoated maghemite, dextran coated magnetite and dextran coated maghemite were investigated for cytotoxicity and neither of the samples exhibited cytotoxicity below 100 mg/mL and the only samples that demonstrated genotoxicity was the dextran coated maghemite (Singh et al, 2012). In a more extensive study, Ding et al (Ding et al, 2010) showed that the cytotoxicity of dextran hybridized magnetite nanoparticles is cell-specific.…”