The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective

Donovan, Sharon M.

doi:10.1016/j.jpeds.2016.02.072

Cited by 90 publications

(63 citation statements)

References 126 publications

(213 reference statements)

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“…Many of these minor proteins are post-translational modified proteins and have their own biological functions. [28][29][30] Although very low in quantity, they may provide significant beneficial activities for infant in immune system and cognitive functions. 28,31,32…”

Section: Resultsmentioning

confidence: 99%

Protein digestion properties of Xinong Saanen goat colostrum and mature milk usingin vitrodigestion model

et al. 2019

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BACKGROUND Xinong Saanen goat milk is a raw material for goat milk‐based infant formula production. This study aims to analyze digestion properties of Xinong Saanen goat colostrum and mature milk by simulating infant gastrointestinal digestion. Zeta potential, particles size, protein profile and peptides composition of these two kinds of milk during the digestion process were studied. RESULTS Zeta‐potential values of the digested colostrum were lower than those of mature milk through the whole digestion. Absolute zeta potential of colostrum duodenal digestion samples showed a decrease from 16.63 ± 2.08 to 11.80 ± 2.03 mV while that of mature milk decreased sharply and then increased (P < 0.05). Colostrum had a larger particle size than mature milk and both milks showed decreased particle size with increasing digestion time but an increase for the last 30 min. Colostrum showed more high molecular weight (MW) proteins which cannot be hydrolyzed completely compared with mature milk. Digested peptides (< 10 kDa) were characterized using liquid chromatography combined with tandem mass spectrometry (LC–MS/MS). The casein‐derived peptides identified in digested colostrum and mature milk accounted for 76.67% and 59.53%, respectively. β‐Casein was the most abundant in colostrum while that in mature milk was αs1‐casein. Enterotoxin‐binding glycoprotein PP20K, butyrophilin subfamily 1 member A1 (BTN1A1) and perilipin (PLIN) were only detected in digested mature milk. CONCLUSION Differences in digestion properties between goat colostrum and mature milk were mainly shown in duodenal digestion phase. Data may provide useful information about utilization of goat milk for infant formula formulation. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Protein digestion properties of Xinong Saanen goat colostrum and mature milk usingin vitrodigestion model

et al. 2019

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“…ITLN1 is a high affinity Lf receptor (Kd = 10 -6 M) able to transduce several Lf-mediated functions, ranging from facilitation of intestinal iron absorption in infants to strengthening of the immune system [87][88][89][90]. A thorough screening of adult murine tissues revealed that INTL1 is expressed in the digestive tract (esophagus, stomach, small intestine, and large intestine), nervous system (cerebellum, hypothalamus, hippocampus, pituitary gland, ganglia, and spinal cord), reproductive system (testes and ovaries) and other organs, such as the pancreas, renal cortex, lung, heart, and liver [91], thus suggesting its pivotal role into the redistribution of circulating Lf into the body.…”

Section: Lactoferrin Bioavailability: Absorption and Body Deliverymentioning

confidence: 99%

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

et al. 2020

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Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the patients. Indeed, except for most of the immunotherapeutic agents, the complete lack of selectivity between normal and cancer cells for radioand chemotherapy can make them potential antagonists of the host anti-cancer self-defense over time. Recently, the use of nutraceuticals as natural compounds corroborating anti-cancer standard therapy is emerging as a promising tool for their relative abundance, bioavailability, safety, low-cost effectiveness, and immuno-compatibility with the host. In this review, we outlined the anti-cancer properties of Lactoferrin (Lf), an iron-binding glycoprotein of the innate immune defense. Lf shows high bioavailability after oral administration, high selectivity toward cancer cells, and a wide range of molecular targets controlling tumor proliferation, survival, migration, invasion, and metastasization. Of note, Lf is able to promote or inhibit cell proliferation and migration depending on whether it acts upon normal or cancerous cells, respectively. Importantly, Lf administration is highly tolerated and does not present significant adverse effects. Moreover, Lf can prevent development or inhibit cancer growth by boosting adaptive immune response. Finally, Lf was recently found to be an ideal carrier for chemotherapeutics, even for the treatment of brain tumors due to its ability to cross the blood-brain barrier, thus globally appearing as a promising tool for cancer prevention and treatment, especially in combination therapies.

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“…Colostrum is the first milk produced and is characterized for containing over 250 potentially immunologically active proteins, including enzymes (lactoferrin, lysozyme, etc. ), hormones, immunoglobulins, cytokines, signaling molecules, soluble receptors and inflammatory mediators . The high content of bioactive proteins evidenced that colostrum's main role is immunological rather than nutritional .…”

Section: Human Milk Among the Stages Of Lactationmentioning

confidence: 99%

Breastfeeding and autoimmunity: Programing health from the beginning

Borba

Sharif

Shoenfeld

2017

American J Rep Immunol

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Breast milk is not only a completely adapted nutrition source for the newborn but also an impressive array of immune-active molecules that afford protection against infections and shape mucosal immune responses. Decisive imprinting events might be modulated during the first months of life with potential health long-term effects, enhancing the importance of breastfeeding as a major influence on the immune system correct development and modifying disease susceptibility. The aim of this review was to clarify the link between breastfeeding and autoimmune diseases, inquiring the related mechanisms, based on data available in the literature. Being breastfed was associated with a lower incidence of diabetes, celiac disease, multiple sclerosis and asthma, explained by the protection against early infections, anti-inflammatory properties, antigen-specific tolerance induction, and regulation of infant's microbiome. The protective role of human milk in idiopathic juvenile arthritis, rheumatoid arthritis, and inflammatory bowel diseases remains controversial. On the other hand, the breastfeeding mother faces a health-challenging period in life. High levels of prolactin may lead either to the development of autoimmune diseases in susceptible mothers or exacerbations of current immune-mediated disorders. These features raise the question if mothers with autoimmune diseases, mainly systemic lupus erythematosus, should avoid breastfeeding.

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The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective

Cited by 90 publications

References 126 publications

Protein digestion properties of Xinong Saanen goat colostrum and mature milk usingin vitrodigestion model

Protein digestion properties of Xinong Saanen goat colostrum and mature milk usingin vitrodigestion model

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

Breastfeeding and autoimmunity: Programing health from the beginning

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