The Role of Microbiomes in Pregnant Women and Offspring: Research Progress of Recent Years

Yao, Yao; Cai, Xiaoyu; Chen, Chunyan; Fang, Hui; Zhao, Yunchun; Fei, Weidong; Chen, Fengying; Zheng, Caihong

doi:10.3389/fphar.2020.00643

Cited by 45 publications

(34 citation statements)

References 125 publications

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“…Studies indicated that the reconstitution of VLDLR expression in macrophages of VLDLR-deficient mice promotes the occurrence and development of atherosclerosis, which may be due to the accumulation of atherosclerotic lipoproteins caused by the knockout of VLDLR (124,125). The physical state of the mother has a profound impact on the health of the fetus (126,127). Maternal-fetal interface studies suggest that VLDLR can induce osteoclasts differentiation and inhibit the inflammatory response of macrophages (128)(129)(130).…”

Section: Maternal Vldlrmentioning

confidence: 99%

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

et al. 2021

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Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and is essential for maintaining normal bone morphology. The interaction between immune cells and osteoclasts in the bone marrow or joint cavity is the basis of osteoimmunity, in which the macrophage-osteoclast axis plays a vital role. Monocytes or tissue-specific macrophages (macrophages resident in tissues) are an important origin of osteoclasts in inflammatory and immune environment. Although there are many reports on macrophages and osteoclasts, there is still a lack of systematic reviews on the macrophage-osteoclast axis in osteoimmunity. Elucidating the role of the macrophage-osteoclast axis in osteoimmunity is of great significance for the research or treatment of bone damage caused by inflammation and immune diseases. In this article, we introduced in detail the concept of osteoimmunity and the mechanism and regulators of the differentiation of macrophages into osteoclasts. Furthermore, we described the role of the macrophage-osteoclast axis in typical bone damage caused by inflammation and immune diseases. These provide a clear knowledge framework for studying macrophages and osteoclasts in inflammatory and immune environments. And targeting the macrophage-osteoclast axis may be an effective strategy to treat bone damage caused by inflammation and immune diseases.

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Section: Maternal Vldlrmentioning

confidence: 99%

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

et al. 2021

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“…However, that hypothesis assumes that the maternal gut or vaginal microbiome that the fetus was exposed to was healthy. Whether the microbiome effects are dependent on maternal health status and the state the gut microbiome warrants further exploration (Koren et al, 2012; Yao et al, 2020).…”

Section: Maternal Microbiome: Implications On Offspring Healthmentioning

confidence: 99%

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

Ishimwe

2021

Physiol Rep

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Preeclampsia is a devastating hypertensive pregnancy disorder that currently affects 2%-8% of pregnancies worldwide. It is associated with maternal and fetal mortality and morbidity and adverse health outcomes both in mom and offspring beyond pregnancy. The pathophysiology is not completely understood, and there are no approved therapies to specifically treat for the disease, with only few therapies approved to manage symptoms. Recent advances suggest that aberrations in the composition of the microbiome may play a role in the pathogenesis of various diseases including preeclampsia. The maternal and uteroplacental environments greatly influence the long-term health outcomes of the offspring through developmental programming mechanisms. The current review summarizes recent developments on the role of the microbiome in adverse pregnancy outcomes with a focus on preeclampsia. It also discusses the potential role of the maternal microbiome in fetal programming; explores gut-targeted therapeutics advancement and their implications in the treatment of preeclampsia.

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“…RA is common among women, and the ratio of men to women is close to 1:3. In women with RA, it seems to be more difficult to conceive, and the disease activity affects the mother and fetal outcome (Wallenius et al, 2011;Wallenius et al, 2012;Yao et al, 2020). For example, RA patients have a longer time to pregnancy (TTP).…”

Section: The Treatment Of Rheumatoid Arthritis During Pregnancy and Lmentioning

confidence: 99%

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

Yao¹,

Cai²,

Fei³

et al. 2020

Front. Pharmacol.

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone destruction. Microbial infection is considered to be the most important inducement of RA. The pregnancy planning of women in childbearing age is seriously affected by the disease activity of RA. Gut microbiome, related to immunity and inflammatory response of the host. At present, emerging evidence suggested there are significant differences in the diversity and abundance of gut microbiome during pregnancy and lactation, which may be associated with the fluctuation of RA disease activity. Based on these research foundations, we pioneer the idea of regulating gut microbiome for the treatment of RA during pregnancy and lactation. In this review, we mainly introduce the potential treatment strategies for controlling the disease activity of RA based on gut microbiome during pregnancy and lactation. Besides, we also briefly generalize the effects of conventional anti-rheumatic drugs on gut microbiome, the effects of metabolic changes during pregnancy on gut microbiome, alteration of gut microbiome during pregnancy and lactation, and the effects of anti-rheumatic drugs commonly used during pregnancy and lactation on gut microbiome. These will provide a clear knowledge framework for researchers in immune-related diseases during pregnancy. Regulating gut microbiome may be a potential and effective treatment to control the disease activity of RA during pregnancy and lactation.

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The Role of Microbiomes in Pregnant Women and Offspring: Research Progress of Recent Years

Cited by 45 publications

References 125 publications

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

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