The Role of MicroRNA in the Pathogenesis and Diagnostics of Parkinson’s Disease

Ardashirova, Natalia S.; Fedotova, Ekaterina Yu.; Иллариошкин, С.Н.

doi:10.1134/s1819712420020026

Cited by 10 publications

(1 citation statement)

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“…Multiple microRNAs were reported to control αsynuclein aggregation either by direct regulation, or by chaperon-mediated autophagy and their downregulation may contribute to α-synuclein-mediated neurotoxicity in PD [38][39][40], (Fig. 2).…”

Section: Mirna Dysregulation In Parkinson's Diseasementioning

confidence: 99%

MicroRNAs in central nervous system disorders: current advances in pathogenesis and treatment

Hussein

Magdy

2021

Egypt J Neurol Psychiatry Neurosurg

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MicroRNAs (miRNAs) are a class of short, non-coding, regulatory RNA molecules that function as post transcriptional regulators of gene expression. Altered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer’s disease, Parkinson’s disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease. miRNAs are implicated in the pathogenesis of excitotoxicity, apoptosis, oxidative stress, inflammation, neurogenesis, angiogenesis, and blood–brain barrier protection. Consequently, miRNAs can serve as biomarkers for different neurological disorders. In recent years, advances in the miRNA field led to identification of potentially novel prospects in the development of new therapies for incurable CNS disorders. MiRNA-based therapeutics include miRNA mimics and inhibitors that can decrease or increase the expression of target genes. Better understanding of the mechanisms by which miRNAs are implicated in the pathogenesis of neurological disorders may provide novel targets to researchers for innovative therapeutic strategies.

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Section: Mirna Dysregulation In Parkinson's Diseasementioning

confidence: 99%