The role of microRNAs in animal physiology and pathology

Szczepanek, Joanna; Pareek, Chandra Shekhar; Tretyn, Andrzej

doi:10.12775/trvs.2018.001

Cited by 3 publications

(2 citation statements)

References 109 publications

(84 reference statements)

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“…The characterization of molecular details of sncRNA biogenesis and silencing mechanism, as well as their scope on different organisms, is a growing research field. There is virtually no physiological process that has not been somehow linked to these molecules, including tumorigenesis, immune and stress response, reproduction, and development 3,4,6,[65][66][67][68][69] .…”

Section: Discussionmentioning

confidence: 99%

Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs

Passamonti

Calderone

Delpero

et al. 2020

Sci Rep

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Gene expression involves multiple processes, from transcription to translation to the mature, functional peptide, and it is regulated at multiple levels. Small RNA molecules are known to bind RNA messengers affecting their fate in the cytoplasm (a process generically termed ‘RNA interference’). Such small regulatory RNAs are well-known to be originated from the nuclear genome, while the role of mitochondrial genome in RNA interference was largely overlooked. However, evidence is growing that mitochondrial DNA does provide the cell a source of interfering RNAs. Small mitochondrial highly transcribed RNAs (smithRNAs) have been proposed to be transcribed from the mitochondrion and predicted to regulate nuclear genes. Here, for the first time, we show in vivo clues of the activity of two smithRNAs in the Manila clam, Ruditapes philippinarum. Moreover, we show that smithRNAs are present and can be annotated in representatives of the three main bilaterian lineages; in some cases, they were already described and assigned to a small RNA category (e.g., piRNAs) given their biogenesis, while in other cases their biogenesis remains unclear. If mitochondria may affect nuclear gene expression through RNA interference, this opens a plethora of new possibilities for them to interact with the nucleus and makes metazoan mitochondrial DNA a much more complex genome than previously thought.

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Section: Discussionmentioning

confidence: 99%

Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs

Passamonti

Calderone

Delpero

et al. 2020

Sci Rep

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“…The potential roles of miRNAs in farm animal diseases have been summarized in several reviews [ 24 , 25 , 26 , 27 , 28 , 29 ]. These reviews, however, only provided an overview of the changes in miRNA expression profiles during disease progression.…”

Section: Introductionmentioning

confidence: 99%

miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies

Ngoc

Dudemaine

Mathur

et al. 2021

IJMS

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MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression post-transcriptionally by targeting either the 3′ untranslated or coding regions of genes. They have been reported to play key roles in a wide range of biological processes. The recent remarkable developments of transcriptomics technologies, especially next-generation sequencing technologies and advanced bioinformatics tools, allow more in-depth exploration of messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), including miRNAs. These technologies have offered great opportunities for a deeper exploration of miRNA involvement in farm animal diseases, as well as livestock productivity and welfare. In this review, we provide an overview of the current knowledge of miRNA roles in major farm animal diseases with a particular focus on diseases of economic importance. In addition, we discuss the steps and future perspectives of using miRNAs as biomarkers and molecular therapy for livestock disease management as well as the challenges and opportunities for understanding the regulatory mechanisms of miRNAs related to disease pathogenesis.

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Milk miRNA expression in buffaloes as a potential biomarker for mastitis

Jadhav,

Ingole,

Bharucha

et al. 2024

BMC Vet Res

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Background Buffaloes have the highest potential for production due to a promising gene pool that is being enhanced and upgraded. Mastitis is a significant health impediment that greatly diminishes milk yield and quality, affecting rural farmers’ livelihoods. The traditional gold standard used for diagnosing mastitis or subclinical mastitis is CMT, but it has the drawback of false positive or negative results. Subclinical mastitis, if not treated promptly, can lead to mammary tumors. To address the gap in early diagnosis of subclinical mastitis in CMT-negative milk of buffaloes, we performed a retrospective analysis and evaluated the milk miRNA expression profiles as potential biomarkers. Results Thirty buffalo milk samples based on clinical signs and CMT were divided into normal, subclinical, and clinical mastitis. SCC evaluation showed significant differences between the groups. The data analysis demonstrated that the elevation of miR-146a and miR-383 differed substantially between normal, subclinical, and clinical mastitis milk of buffaloes with 100% sensitivity and specificity. The relationship of SCC with miR-146a and miR-383 in normal/healthy and subclinical mastitis was positively correlated. Conclusion The overexpression of miR-146a and miR-383 is associated with inflammation. It can be a valuable prognostic and most sensitive biomarker for early mastitis detection in buffaloes with SCC below 2 lakhs and CMT-ve, enhancing the accuracy of subclinical mastitis diagnosis.

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The role of microRNAs in animal physiology and pathology

Cited by 3 publications

References 109 publications

Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs

Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs

miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies

Milk miRNA expression in buffaloes as a potential biomarker for mastitis

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