The role of neuroplasticity in experimental neck pain: A study of potential mechanisms impeding clinical outcomes of training

Rittig-Rasmussen, Bjarne; Kasch, Helge; Fuglsang-Frederiksen, Anders; Svensson, Peter; Jensen, Troels Staehelin

doi:10.1016/j.math.2014.04.010

Cited by 20 publications

(37 citation statements)

References 52 publications

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“…TMS studies have shown that experimental pain stimulation can alter the excitability of the corticomotor system (Farina et al 2001; Valeriani et al 2001). However, contrary to the study by Stancák et al (that suggest a priming of the motor cortex in the presence of pain), TMS studies generally report reduced corticospinal excitability following nociceptive stimuli (Boudreau et al 2007; Mercier and Leonard 2011; Schabrun and Hodges 2012; Schabrun et al 2013; Rittig-Rasmussen et al 2014). Some researchers have suggested that these corticomotor effects could explain the negative impact that pain can have on motor learning (Boudreau et al 2007; Rittig-Rasmussen et al 2014).…”

Section: Introductionmentioning

confidence: 84%

“…However, contrary to the study by Stancák et al (that suggest a priming of the motor cortex in the presence of pain), TMS studies generally report reduced corticospinal excitability following nociceptive stimuli (Boudreau et al 2007; Mercier and Leonard 2011; Schabrun and Hodges 2012; Schabrun et al 2013; Rittig-Rasmussen et al 2014). Some researchers have suggested that these corticomotor effects could explain the negative impact that pain can have on motor learning (Boudreau et al 2007; Rittig-Rasmussen et al 2014). Supporting this are the results of Rittig-Rasmussen et al (Rittig-Rasmussen et al 2014) who have observed that the change in corticospinal excitability (increased motor-evoked potential [MEP] amplitudes) noted following upper trapezius training was completely blocked by a hypertonic muscle saline injection, with the effect being apparent up to 7 days post-training.…”

Section: Introductionmentioning

confidence: 84%

“…Some researchers have suggested that these corticomotor effects could explain the negative impact that pain can have on motor learning (Boudreau et al 2007; Rittig-Rasmussen et al 2014). Supporting this are the results of Rittig-Rasmussen et al (Rittig-Rasmussen et al 2014) who have observed that the change in corticospinal excitability (increased motor-evoked potential [MEP] amplitudes) noted following upper trapezius training was completely blocked by a hypertonic muscle saline injection, with the effect being apparent up to 7 days post-training.…”

Section: Introductionmentioning

confidence: 99%

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Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

et al. 2017

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The interaction between pain and the motor system is well-known, with past studies showing that pain can alter corticomotor excitability and have deleterious effects on motor learning. The aim of this study was to better understand the cortical mechanisms underlying the interaction between pain and the motor system. Experimental pain was induced on 19 young and healthy participants using capsaicin cream, applied on the middle volar part of the left forearm. The effect of pain on brain activity and on the corticomotor system was assessed with electroencephalography (EEG) and transcranial magnetic stimulation (TMS), respectively. Compared to baseline, resting state brain activity significantly increased after capsaicin application in the central cuneus (theta frequency), left dorsolateral prefrontal cortex (alpha frequency), and left cuneus and right insula (beta frequency). A pain-evoked increase in the right primary motor cortex (M1) activity was also observed (beta frequency), but only among participants who showed a reduction in corticospinal output (as depicted by TMS recruitment curves). These participants further showed greater beta M1-cuneus connectivity than the other participants. These findings indicate that pain-evoked increases in M1 beta power are intimately tied to changes in the corticospinal system, and provide evidence that beta M1-cuneus connectivity is related to the corticomotor alterations induced by pain. The differential pattern of response observed in our participants suggest that the effect of pain on the motor system is variable from on individual to another; an observation that could have important clinical implications for rehabilitation professionals working with pain patients.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

et al. 2017

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“…Items consistently unmet by reviewed studies related to internal and external validity. For example, male and female participants were unequally represented in the majority of study samples (Macefield et al, 2007) and sample size calculations were rarely performed a priori (Rittig-Rasmussen et al, 2014). No study blinded the investigator during data analysis and all recruited a sample of convenience.…”

Section: Methodological Qualitymentioning

confidence: 99%

Primary sensory and motor cortex function in response to acute muscle pain: A systematic review and meta‐analysis

Burns

Chipchase

Schabrun

2016

European Journal of Pain

103

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Acute muscle pain has both motor and sensory consequences, yet the effect of muscle pain on the primary sensory (S1) and motor (M1) cortices has yet to be systematically evaluated. Here we aimed to determine the strength of the evidence for (1) altered activation of S1/ M1 during and after pain, (2) the temporal profile of any change in activation and (3) the relationship between S1/M1 activity and the symptoms of pain. In September 2015, five electronic databases were systematically searched for neuroimaging and electrophysiological studies investigating the effect of acute experimental muscle pain on S1/ M1 in healthy volunteers. Demographic data, methodological characteristics and primary outcomes for each study were extracted for critical appraisal. Meta-analyses were performed where appropriate. Twenty-five studies satisfied the inclusion criteria. There was consistent evidence from fMRI for increased S1 activation in the contralateral hemisphere during pain, but insufficient evidence to determine the effect at M1. Meta-analyses of TMS and EEG data revealed moderate to strong evidence of reduced S1 and corticomotor excitability during and following the resolution of muscle pain. A comprehensive understanding of the temporal profile of altered activity in S1/M1, and the relationship to symptoms of pain, is hampered by differences in methodological design, pain modality and pain severity between studies. Overall, the findings of this review indicate reduced S1 and corticomotor activity during and after resolution of acute muscle pain, mechanisms that could plausibly underpin altered sensorimotor function in pain. What does this review add?: We provide the first systematic evaluation of the primary sensory (S1) and motor (M1) cortex response to acute experimental muscle pain in healthy volunteers. We present evidence from a range of methodologies to provide a comprehensive understanding of the effect of pain on S1/M1. Through meta-analyses we evaluate the strength of evidence concerning the direction and temporal profile of the S1/M1 response to acute muscle pain.

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“…Data will then be organised into windows to capture commonly assessed time frames during and after recovery from pain (Figure 1). For example, in tonic pain models, MEPs have been measured 0-10 [26], 11-20 [27] and 21-30 [28] minutes after pain resolution.…”

Section: Data Synthesismentioning

confidence: 99%

The Influence of Experimental Pain on Primary Motor Cortex Function: Protocol for a Systematic Review and Meta-analysis

Chowdhury

Chang

Millard

et al. 2020

Preprint

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Introduction: The primary motor cortex (M1) is a key brain region implicated in pain processing. Here, we present a protocol for a review that aims to synthesise and critically appraise the evidence for the effect of experimentalpain on M1 function. Methods/Analysis: A systematic review and meta-analysis will be conducted. Electronic databases will be searched using a predetermined strategy. Studies published before April 2020 that investigate the effects of experimentally induced pain on corticomotor excitability (CME) in healthy individuals will be included if they meet eligibility criteria. Study identification, data extraction andrisk of bias assessment will be conducted by two independent reviewers, with a third reviewer consulted for any disagreements. The primary outcomes will include group level changes in CME and intracortical, transcortical and sensorimotor modulators of CME. A separate analysis using individual data will also be conducted to explore individual differences in CME in response to experimental pain. The meta-analysis will consider the following factors: pain model (transient, tonic, transitional pain), type of painful tissue (cutaneous, musculoskeletal), time points of outcome measures(during or after recovery from pain) and localisation of pain(target area, control area). Discussion: This review will provide a comprehensive understanding of the mechanisms within M1 that mediate experimentally induced pain, both on a group and individual level. Registration Number: The systematic review is registered with the International Prospective Register of Systematic Reviews (#CRD42020173172)

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The role of neuroplasticity in experimental neck pain: A study of potential mechanisms impeding clinical outcomes of training

Cited by 20 publications

References 52 publications

Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

Primary sensory and motor cortex function in response to acute muscle pain: A systematic review and meta‐analysis

The Influence of Experimental Pain on Primary Motor Cortex Function: Protocol for a Systematic Review and Meta-analysis

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