The Role of NKG2D in Vitiligo

Plaza-Rojas, Lourdes; Guevara-Patiño, José A.

doi:10.3389/fimmu.2021.624131

Cited by 15 publications

(10 citation statements)

References 163 publications

(152 reference statements)

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“…Autoreactive cytotoxic CD8 + T cells specifically damage melanocytes and provoke the development and progression of vitiligo via presentation of IFN-γ and other cytotoxic effectors ( 50 ). Keratinocytes and fibroblasts stressed by IFN-γ can secrete chemokines CXCL9 and CXCL10, recruiting more CD8 + T cells to skin lesions ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chang

Zhang

et al. 2022

Front. Med.

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Background and ObjectivesThe efficacy of camouflage combined with psychotherapy and the underlying mechanisms are poorly understood in vitiligo management. This study aimed to investigate the joint efficacy and further explore psycho-neuro-endocrine-immune-skin interactions.Patients and MethodsIn a prospective, non-randomized and concurrent controlled trial, patients were divided into two groups. Quality of life (QOL) was evaluated using the Chinese version of the Vitiligo Life Quality Index (VLQI-C). Serum levels of neuropeptides and cytokines were detected by enzyme-linked immunosorbent assay.ResultsA total of 149 patients were included for final evaluation. After treatment for 4 weeks, total and subcategory quality of life scores in the intervention group were much lower than in the control group. Serum levels of neuropeptide-Y (NPY) and melanin-concentrating hormone (MCH) significantly decreased, and serum level of adrenocorticotropic hormone (ACTH) increased in both active and stable patients of the intervention group, but not in the control group. In addition, the serum levels of interferon-γ (IFN-γ), CXC chemokine ligand 10 (CXCL10), and interleukin-1β (IL-1β) decreased in both the active and stable patients of the intervention group and only in the active patients of the control group.ConclusionsThe combination of camouflage and psychotherapy provided a clinically meaningful improvement in quality of life and ameliorated the outcome by likely modulating the psycho-neuro-endocrine-immuno-skin system during vitiligo management.Clinical Trial Registrationwww.clinicaltrials.gov/ct2/show/NCT03540966, identifier: NCT03540966.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chang

Zhang

et al. 2022

Front. Med.

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“…Environmental stress can trigger the onset of vitiligo [10,11], especially in adulthood. Striae-induced Koebner phenomenon is observed in vitiligo [61][62][63], and the fact that striae are more common in taller individuals with intense growth spurts can explain the increased risk of vitiligo with height.…”

Section: Discussionmentioning

confidence: 99%

“…Particularly frustrating are the unpredictable disease course and lack of FDA-approved effective therapy [8,9]. Despite the effort expended to develop ground-breaking therapeutics, vitiligo remains incurable [10]. Identification of risk factors that enable early screening of susceptible individuals would be beneficial.…”

Section: Introductionmentioning

confidence: 99%

Height and Risk of Vitiligo: A Nationwide Cohort Study

Lee

Kim

2021

JCM

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Adult height is linked to the risk of several diseases, but its association with vitiligo has not been established. This study aimed to investigate the relationship between adult height and vitiligo incidence. Korean nationwide claims data from 15,980,754 individuals (20 years of age or older) who received a health checkup during the period 2005–2008, were examined. Subjects were categorized into age- and gender-specific height quintiles. Participants were followed until vitiligo diagnosis or until the end of 2015. The Cox proportional-hazards model for cumulative risk was computed for height categories. During the follow-up period, 29,196 cases (136,020,214 person-years) of newly diagnosed vitiligo were reported. A positive association was found between height and risk of vitiligo in which the hazard ratio between the highest and lowest quintiles of height was 1.36 (95% confidence interval: 1.31–1.42). While more diverse cohort studies are needed, our findings suggest that taller stature increases the risk of vitiligo.

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“…As a result, many of the target antigens of melanocytes are located in melanosomes. Under cellular stress, melanocytes produce heat shock proteins (HSP) (especially HSP70), danger‐associated molecular patterns, such as High Mobility Group Box 1 (HMGB1) and ligands of NKG2D (e.g., MICA/B and ULBP1; Figure 1; Mosenson et al, 2014; Plaza‐Rojas & Guevara‐Patiño, 2021). The expression of NKG2D ligands makes melanocytes vulnerable to immune‐targeted destruction.…”

Section: Melanocytes and Immunitymentioning

confidence: 99%

The delicate relation between melanocytes and skin immunity: A game of hide and seek

Speeckaert

Belpaire

Speeckaert

et al. 2022

Pigment Cell Melanoma Res

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Melanocytes exhibit a complex and intriguing relationship with the skin immune response, leading to several clinical conditions. In some disorders, inappropriate melanocyte destruction (e.g., vitiligo, halo naevi) is problematic, while in others, immune tolerance should be broken (melanoma). Important parts of the dysregulated pathways have been unraveled in pigment disorders, ranging from upregulated interferon (IFN)‐γ signaling to memory T cells, regulatory T cells, and immune checkpoints. Although a network of many factors is involved, targeting key players such as IFN‐γ or checkpoint inhibitors (e.g., programmed death‐ligand 1 (PD‐L1)] can shift the balance and lead to impressive outcomes. In this review, we focus on the immunological mechanisms of the most common inflammatory disorders where the interaction of the immune system with melanocytes plays a crucial role. This can provide new insights into the current state of melanocyte research.

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The Role of NKG2D in Vitiligo

Cited by 15 publications

References 163 publications

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Height and Risk of Vitiligo: A Nationwide Cohort Study

The delicate relation between melanocytes and skin immunity: A game of hide and seek

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