The role of osteocalcin in the connection of bone and glucose metabolism in humans

Buday, Barbara; Kulcsár, Enikő; Nagy, Benedek; Horváth, Tünde; Vitai, Márta; Vecsei, Istvánné; Bezzegh, Katalin; Kiss, József; Péterfai, Éva; Kopper, László; Korányi, László

doi:10.1556/oh.2008.28518

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Another player in the hormonal regulation caused by spirulina would be osteocalcin. Osteocalcin, also stimulates pancreatic -cells to release more insulin, increasing insulin sensitivity [52][53][54][55][56]. Our data show that while osteocalcin levels decreased significantly in the control group over the experimental period, spirulina treatment significantly increased osteocalcin levels over time (p < 0.001); moreover, the increases were dose-dependent.…”

Section: Discussionmentioning

confidence: 56%

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

et al. 2020

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In recent years, growth hormone deficiency in children has been treated with hormone therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children’s growth. Spirulina platensis is known for its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well as its high digestibility and high protein content, but little has been reported about its influence on bone development in children with a normal supply of protein. In this study, we evaluated the effects of spirulina on the bone metabolism and antioxidant profiles of three-week-old growing male rats. The animals were divided into four groups (n = 17 per group) and were fed AIN93G diets with 0% (control), 30% (SP30), 50% (SP50), and 70% (SP70) of casein protein replaced by spirulina, respectively, for seven weeks. We observed that spirulina enhanced bone growth and bone strength by stimulating parathyroid hormone and growth hormone activities, as well its increased antioxidant activity. These results indicate that spirulina provides a suitable dietary supplement and alternative protein source with antioxidant benefits for growth improvement in early developmental stages.

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Section: Discussionmentioning

confidence: 56%

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

et al. 2020

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“…Recent studies in humans have also shown a relationship between OC and carbohydrate metabolism 5,6,16 . There is an association between OC and insulin sensitivity in healthy individuals 17 . Moreover, it has also been reported that OC is inversely related to fat mass and glucose in the elderly 5 and postmenopausal women 18 .…”

Section: Discussionmentioning

confidence: 97%

“…5,6,16 There is an association between OC and insulin sensitivity in healthy individuals. 17 Moreover, it has also been reported that OC is inversely related to fat mass and glucose in the elderly 5 and postmenopausal women. 18 Other studies have found that serum OC levels are negatively correlated with blood glucose levels, fat mass and markers of atherosclerosis such as brachial-ankle pulse wave velocity and thickness of the intima-media, and positively with total adiponectin in T2D.…”

Section: Discussionmentioning

confidence: 97%

Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

Iglesias¹,

Arrieta

Piñera

et al. 2011

Clinical Endocrinology

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“…The association between ucOC levels and glucose homeostasis is consistent and there is a large evidence reporting the role of ucOC as a regulator of glucose and energy metabolism 48,49 . Higher levels of this protein have been related to an improvement in insulin sensitivity and secretion due to the direct action of ucOC on adipocytes and β-cell mass 50 . As above mentioned, within a population of MetS patients, there are patients at higher risk than others to become diabetic patients depending on their metabolic profile.…”

Section: Discussionmentioning

confidence: 99%

Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients

Riquelme-Gallego

García-Molina

Cano-Ibáñez

et al. 2020

Sci Rep

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Undercarboxylated osteocalcin (ucoc) could be a biomarker of glucose disturbances and cardiovascular risk. our study aimed to determine the association between serum levels of ucoc and cardiovascular risk in metabolic syndrome (MetS) patients and to analyse its potential role as estimator of type 2 diabetes (T2D) risk in this population. This cross-sectional study included 235 patients with MetS, 53.2% women, aged 55-75 years. Circulating ucOC levels were measured by ELISA. Cardiovascular risk was determined as Z-score of the diagnostic criteria for MetS (CV-ZS). Linear regression model was performed to analyse the association between circulating ucoc and cV-ZS. A receiver operating curve (ROC) was performed to analyse the usefulness of ucOC as T2D risk estimator. Patients above the CV-ZS median showed significant lower ucOC levels. We found an inverse association between ucOC levels and CV-ZS in MetS patients without T2D. Patients with ucOC levels below the 25 th percentile showed worse cardiometabolic profile and higher cardiovascular and T2D risk. The area under the curve performed better when ucOC levels were included along with the classic T2D risk factors. The measurement of circulating ucOC could be a useful tool to identify increased cardiovascular and T2D risk in MetS patients without T2D. Current lifestyle is causing a remarkable increase in overweight up to epidemic numbers globally 1. In Spain, over 60% of the adult population is overweight or obese 2. According to this trend, an increase of 16% in the number of cases is estimated by 2030 associated with a 58% increase in direct healthcare costs 3. A large body of evidence has shown that all-cause mortality, and especially cardiovascular-related mortality, is associated with an increased central adiposity and overweight 4. Visceral obesity in conjunction with other disorders, such as dyslipidaemia, hypertension and fasting hyperglycaemia lead to the metabolic syndrome (MetS), conferring thus a larger risk of developing cardiovascular disease (CVD) 5. An association between osteoporosis, CVD and cardiovascular-related mortality has been reported 6,7. The common risk factors involved in bone fragility and CVD could partially explain this association. Therefore, the

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The role of osteocalcin in the connection of bone and glucose metabolism in humans

Abstract: This study confirmed the relationship between insulin sensitivity and osteocalcin in healthy human population, although basic difference was found between the two genders which was not related to osteocalcin.

Cited by 10 publications

References 20 publications

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients

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