The role of oxytocin in the pathogenesis of endometriosis: various aspects of the problem

Abstract

Hypothesis/aims of study. Endometriosis is a chronic recurrent disease that leads to a significant decrease in the quality of life. Despite the existing therapeutic methods, the prevalence of the disease is steadily increasing. The pathogenesis of endometriosis has not been studied enough, resulting in failure to achieve high efficiency in its treatment. Due to chronic pelvic pain, infertility, and dissatisfaction with the quality of life, women suffering from endometriosis present with various mental disorders of different degrees of severity. This study aims to summarize the literature discussing the possible role of oxytocin in the pathogenesis of both endometriosis and affective disorders.
 Study design, materials, and methods. Literature data for the period from 1986 to 2019.
 Conclusion. The role of oxytocin in the pathogenesis of endometriosis needs further study. Oxytocin receptor antagonists can be considered promising in the treatment of this medical condition, as well as in prevention and management of affective disorders in patients with endometriosis.

The potentialities of oxytocin receptor inhibitors for endometriosis therapy

“…OXT possible participation in proliferating processes has recently become an objective for a number of studies. Despite the ambiguousness of their data, we assume that OXT is capable of potentiating endometrioid heterotopy growth and development [16] which was also confirmed by our experimental study part where IOXTR treatment efficacy was estimated based on surgically induced endometriosis animal model of Wistar line rats. OXTR antagonist administration high efficacy was demonstrated (endometrioid heterotopy authentic regression or complete resorption).…”