The article presents the results of research to determine the optimal technological methods of growing seed potatoes. The optimal nutrition background and method of fertilizer application, weight of planting tubers and potato varieties have been established, which provide high indicators of economic and energy efficiency of these elements of potato growing technology. The highest indicators of economic efficiency of potato growing were noted in the experimental version, where against the background of phosphorus-potassium fertilizer and the action of semi-roasted manure was carried out local application of Nitroammophoska (N45P45K45). The highest conditional net profit was 228,300 and 184,900 UAH / ha in the varieties Granada and Memphis for fraction of seed tubers 28-60 mm. However, the highest profitability was observed against this background of nutrition and method of application, but for fraction of seed tubers < 28 mm in varieties of Granada - 216.6; Memphis - 178.1 and Laperla - 153.1%, and fraction of seed tubers 28-60 mm - 157.6; 126.9 and 102.4%, respectively, in these varieties of potatoes. The decrease in the level of profitability was observed for fraction of seed tubers ˃ 60 mm to 99.9; 78.6 and 59.1%, respectively. This is due to the significant costs of planting material from 5.4 to 5.5 t / ha and the increase in the cost of planting material, and despite the increase in yields has led to lower profitability. Option, where against the background of phosphorus-potassium fertilizer and the action of semi-fermented manure was carried out local application of Nitroammophoska (N45P45K45) provided the highest energy efficiency. Thus, the energy yield with a yield ranged from 109.89 to 141.71 and from 120.25 to 152.07 GJ / ha with an increase in the fraction of seed tubers and different varietal composition. The highest coefficient of energy efficiency was observed for fraction of seed tubers < 28 mm, which varied from 1.78 to 2.28 and was less than the maximum for fraction of seed tubers ˃ 60 mm - 1.62-2.04.