The Role of Photodynamic Therapy in the Treatment of Primary, Recurrent and Metastatic Malignant Brain Tumors

Abstract

Photodynamic therapy is a relevant and promising area for research in the field of clinical neuroonocology. Application of modern developments in the field of laser technologies and new photosensitizers allows us to refer to this field as to high-tech. According to various authors, the inclusion of photodynamic therapy in combined and complex treatments of patients with malignant brain tumors allows achieving overall survival median of patients from 11 to 26 months for primary form of glioblastoma, and from 7.5 to 15 months - for recurrent forms of glioblastoma. Certain results have been achieved in the treatment of patients with metastatic brain lesion. In this publication the authors analyzed and systematized the results of the main clinical studies in the field of fluorescent diagnostics and intraoperative photodynamic therapy of primary, recurrent and metastatic forms of malignant brain tumors.

Photodynamic Therapy: A Compendium of Latest Reviews

“…[90] Current status and prospects of PDT in Japan. 2018 [91] A systematic review of clinical trials. 2020 [92] Complete review of PDT and novel OCT strategies.…”

“…Additionally, 5-Aminolevulinic acid-FGR with postop cavitary HpD PDT has shown better results than control, but there is not a proper comparison to standard of care [89]. Another systematic review of the main clinical studies in the field of fluorescent diagnostics and intraoperative photodynamic therapy of primary, recurrent, and metastatic forms of malignant brain tumours can be found in [91], but it is not translated to English.…”

“…Cancers 2021, 13 12 of 29 than control, but there is not a proper comparison to standard of care [89]. Another systematic review of the main clinical studies in the field of fluorescent diagnostics and intraoperative photodynamic therapy of primary, recurrent, and metastatic forms of malignant brain tumours can be found in [91], but it is not translated to English. guidance, and the surgical approach and trajectories can be planned using preoperative diffusion magnetic resonance imaging (MRI), CT imaging, and/or single-photon emission computed tomography (SPECT) images to achieve precise tumour localization, realize a minimally invasive craniotomy, and minimize controlateral brain injury.…”