The Role of Potassium Channels in the Vasodilatation Induced by Resveratrol and Naringenin in Isolated Human Umbilical Vein

Protić, Dragana; Radunović, Nebojša; Spremović-Radjenović, Svetlana; Živanovic, V.; Heinle, H.; Petrović, Aleksandar; Gojkovic-Bukarica, Ljiljana

doi:10.1002/ddr.21236

Cited by 19 publications

(12 citation statements)

References 24 publications

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“…Also, the effects of resveratrol in vivo may also involve its actions on potassium channels [27,28,29], gut microbiota [30,31], and circadian gene expression [32].…”

Section: Resveratrol and Its Molecular Targetsmentioning

confidence: 99%

Resveratrol and Vascular Function

Xia

Hasselwander

et al. 2019

IJMS

156

126

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Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathological stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major molecules mediating the vascular effects of resveratrol.

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“…Also, the effects of resveratrol in vivo may also involve its actions on potassium channels [27,28,29], gut microbiota [30,31], and circadian gene expression [32].…”

Section: Resveratrol and Its Molecular Targetsmentioning

confidence: 99%

Resveratrol and Vascular Function

Xia

Hasselwander

et al. 2019

IJMS

156

126

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“…In addition, RJ is still able to relax the endothelium‐denuded aorta rings, indicating that RJ has a direct relaxation effect on VSMC. Although changes in the K + channel activity of VSMC membranes regulate membrane potential, which is an important mechanism involved in arterial vasoconstriction and vasodilation (Kohler, Kaistha, & Wulff, ; Protic et al, ). However, RJ not only had weak vasodilation effect on the KCl models, and different types of potassium channel blockers also had no effect on RJ’s vasorelaxation (Data not shown).…”

Section: Discussionmentioning

confidence: 99%

Royal jelly causes hypotension and vasodilation induced by increasing nitric oxide production

Pan

Rong

You

et al. 2019

Food Science & Nutrition

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Among royal jelly’s (RJ) various biological activities, its possible antihypertension and vasorelaxation effects deserve particular attention, but the underlying mechanisms of action remain unclear. Therefore, this study used the spontaneously hypertensive rats (SHR) hypertension model and the isolated rabbit thoracic aorta rings model to explore the mechanisms underlying the hypotension and vasorelaxation effects of RJ. Rats were divided into the following groups ( n = 6): WKY‐control group, SHR‐control group, and SHR‐RJ group. SHR‐RJ group was received 1 g/kg of RJ via oral administration daily for 4 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and nitric oxide (NO) level were detected. In addition, the mechanism of vasodilation of RJ was investigated using an isolated rabbit aortic ring technique. RJ significantly reduced SBP and DBP as well as increased NO levels of SHR in vivo. RJ caused vasorelaxation of the isolated aorta rings, and this effect was inhibited by atropine (M 3 receptor blocker), L‐NAME (nitric oxide synthase inhibitor), methylene blue (guanylate cyclase inhibitor), and indomethacin (cyclooxygenase inhibitor). Moreover, RJ could markedly suppress the NE‐induced intracellular Ca 2+ releases and high K + ‐induced extracellular Ca 2+ influx in denuded aortic rings. In addition, RJ can also increase cGMP levels and the production of NO in isolated aortic rings. The present study showed that RJ has antihypertensive effects and was associated with increased NO production. In addition, RJ contains muscarinic receptor agonist, possibly an acetylcholine‐like substance, and induces vasodilation through NO/cGMP pathway and calcium channels.

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“…The findings are consistent with the data obtained on different blood vessels (rat portal vein, porcine retinal arterioles and human umbilical vein). It has been shown that, without endothelium, the BK Ca channels partly mediate the relaxant effect of RSV (6,7,79). Nevertheless, the results of previous studies show that BK Ca channels were not involved in the relaxant effect of RSV in blood vessels without endothelium-rat aorta, mesenteric artery and in human mammary artery (5,59,77,80,81).…”

Section: Effects Of Resveratrol On the Smooth Muscle K Ca Channelsmentioning

confidence: 97%

“…However, only BK Ca smooth muscle channels were partly involved in the RSV-induced inhibition of neurogenic contractions. Another investigation of the effects of RSV on vein was on human umbilical vein (79). In vitro studies of this endothelium-denuded vein reveal that Kv, K Ca , and Kir channels play important role in the RSV-induced vasodilatation.…”

Section: Effects Of Resveratrol On the Smooth Muscle Potassium Channels In Cardiovascular Systemmentioning

confidence: 99%

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Rajković

Djokic

Gostimirović

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. K channels play a crucial role in maintaining membrane potential. Inhibition of K channels causes membrane depolarization and then contraction of smooth muscles, while the activation leads to membrane hyperpolarization and subsequently, relaxation. Five diverse types of K channels have been identified in smooth muscle cells in different tissue: ATP-sensitive K channels (K ATP ), voltage-dependent K channels (Kv), Ca 2+ -and voltagedependent K channels (BK Ca ), inward rectifier K channels (Kir), and tandem two-pore K channels (K 2P ). The expression and activity of K channels altered in many types of diseases. Aberrant function or expression of K channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, preeclampsia, and various types of cancer. Modulation of K channel activity by molecular approaches and selective drug development may be a novel treatment modality for these dysfunctions in the future. The plant-derived non-toxic polyphenols, such as resveratrol, can alter K channel activity and lead to the desired outcome. This review presents the basic properties, physiological, pathophysiological functions of K channels, and pharmacological roles of resveratrol on the major types of K channels that have been determined in smooth muscle cells.

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The Role of Potassium Channels in the Vasodilatation Induced by Resveratrol and Naringenin in Isolated Human Umbilical Vein

Cited by 19 publications

References 24 publications

Resveratrol and Vascular Function

Resveratrol and Vascular Function

Royal jelly causes hypotension and vasodilation induced by increasing nitric oxide production

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

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