The role of prebiotics in cognition, anxiety, and depression

Paiva, Igor Henrique Rodrigues de; Duarte-Silva, Eduardo; Peixoto, Christina Alves

doi:10.1016/j.euroneuro.2020.03.006

Cited by 75 publications

(41 citation statements)

References 132 publications

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“…Thus, supplementation of vitamins (such as vitamin B complex) may also be helpful in delineating a treatment of AD. Prebiotics promote the growth of beneficial bacteria (including lactobacillus and bifidobacteria), and improve dysbiosis and the associated inflammatory conditions that may ameliorate cognitive impairment [111]. Conversely, the Western diet, consisting of saturated and high trans-fat, high sugar with fewer vegetables and fruits is considered a nutrient-imbalanced diet pattern [107].…”

Section: Diet and Food Componentsmentioning

confidence: 99%

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

et al. 2021

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The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may disturb intestinal permeability and the blood–brain barrier. In addition, it can promote the hallmarks of AD, such as oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, and ultimately the causation of neural death. Poor dietary habits and aging, along with inflammatory responses due to dysbiosis, may contribute to the pathogenesis of AD. Thus, GM modulation through diet, probiotics, or fecal microbiota transplantation could represent potential therapeutics in AD. In this review, we discuss the role of GM dysbiosis in AD and potential therapeutic strategies to modulate GM in AD.

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Section: Diet and Food Componentsmentioning

confidence: 99%

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

et al. 2021

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“…Prebiotic application has been associated with decreased fasting glucose, improved insulin sensitivity, and lipid profile, reduced inflammation markers and modulation of neuroinflammation [89,90]. It has been proposed that probiotics may act via a number of routes, including modulation of the immune system and antimicrobial substances, increasing competition against pathogenic microorganisms, enhancing the intestinal barrier function, and increasing the production of anti-inflammatory molecules and antioxidants [91].…”

Section: Microbiota Interventions In Depressive and Metabolic Disordersmentioning

confidence: 99%

Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

Gawlik-Kotelnicka

Strzelecki

2021

Life

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Some of the most common and debilitating conditions are metabolic disorders (metabolic syndrome and non-alcoholic fatty liver disease) and depression. These conditions are also exacerbated by the fact that they often co-occur. Although the exact mechanisms underlying such relationships are poorly known, antipsychotic medication and antidepressant use, diet and physical activity, and lifestyle factors are believed to play a role; however, their high co-occurrence rate suggests a possible pathophysiological overlap. This paper reviews several possible bases for this overlap, including hypothalamic-pituitary-adrenal axis dysregulation, immune alterations with chronic inflammation, and oxidative stress. While it is entirely possible that changes in the microbiota may play a role in each of them, interventions based on the implementation of dietary and other lifestyle changes, supplementation with prebiotics or probiotics and faecal microbiota transplantation have failed to achieve conclusive results. A better characterization of the above associations may allow a more targeted approach to the treatment of both depressive and metabolic disorders. The paper also presents several practical applications for future studies.

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“…It is known that bacteria from Bifidobacteria and Lactobacillus genus provide a local anti-inflammatory effect on the intestinal wall. The recovery of the barrier function of intestinal epithelium occurs because of the decrease of inflammation in the intestinal wall, meaning that the level of inflammatory mediators decreases in systemic circulation and consequently their activating effect on the nervous system reduces [ 145 , 146 , 147 ]. In particular, hypertension is associated with disturbance of gut microbiome and dysregulation of gut–brain axis.…”

Section: The Neuroimmune Axis: Microbiota–intestine–brain-cvdmentioning

confidence: 99%

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Suslov

Chairkina

Shepetovskaya

et al. 2021

JCM

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Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic–pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease.

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The role of prebiotics in cognition, anxiety, and depression

Cited by 75 publications

References 132 publications

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

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