The role of primary transoral laser microsurgery in laryngeal cancer: a retrospective study

Abstract

In carefully selected patients with laryngeal cancer, primary transoral laser microsurgery with or without adjunctive therapy can be organ preserving. It can provide a valid treatment option for patients.

Outcomes of transoral laser microsurgical management of T1bstage glottic cancer

“…Current reports, including a meta-analysis by Abdurehim et al . which identifies laryngeal preservation as the sole oncological parameter associated with more favourable outcomes for transoral laser microsurgery over RT, support the finding of a high laryngeal preservation rate in early glottic cancer patients in the current study 8 10 , 28 , 29 More specifically, the present findings match the five-year anterior commissure involvement rates for early glottic cancer and T 1b of approximately 96 per cent and 88–100 per cent, respectively 6 …”

“…As a consequence of the recent shift in focus towards functional preservation, transoral laser microsurgery is often a primary treatment for these malignancies. There is now a strong body of evidence supporting similar oncological outcomes between transoral laser microsurgery and radiotherapy (RT) for managing early laryngeal cancer, 7 , 8 with some studies reporting greater local control, laryngeal preservation and overall survival rates with transoral laser microsurgery 9 11 Although controversy remains about voice outcomes, 12 these interventions are now generally believed to yield equivalent results 3…”

Margins in Laryngeal Squamous Cell Carcinoma Treated with Transoral Laser Microsurgery: A National Database Study

“…Other studies in the literature similarly report low numbers of supraglottic cases undergoing TLM, making meaningful comparisons between subsites difficult. 31…”

Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling

“…https://www.nice.org.uk/guidance/ng36), with salvage laryngectomy or radiotherapy for recurrence . Rates of local control and 5‐year survival in early‐stage tumours are similar following radiotherapy or TLM (~80%), and meta‐analyses in early glottic cancers suggest improved survival following TLM, with uncertainty regarding vocal quality outcomes . Options for T3/T4 LSCC include radiotherapy, concurrent platinum‐based chemo‐radiotherapy, primary partial or total laryngectomy .…”

“…1 Rates of local control and 5-year survival in early-stage tumours are similar following radiotherapy or TLM (~80%), and meta-analyses in early glottic cancers suggest improved survival following TLM, with uncertainty regarding vocal quality outcomes. 3,4 Options for T3/T4 LSCC include radiotherapy, concurrent platinum-based chemo-radiotherapy, primary partial or total laryngectomy. 2,5 Post-radiotherapy recurrence is a major problem, with radiotherapy failure rates of 9%-21% in T1 glottic and 28%-37% in T2 glottic LSCC.…”