The Role of Protective Varnishes in the Treatment of Initial Caries

Obradović, Marija; Dolić, Olivera; Sukara, Slava; Vojinović, Jovan

doi:10.7251/comen1602091o

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…16 To date, majority of published studies demonstrated superiority of CPP-ACP fluoride varnishes when compared to conventional fluoride varnishes. [17][18][19][20] However, in our study the comparison of remineralisation efficacy between the G1 and CPP-ACP compounds fluoride varnish was not significant. it was concluded that both fluoride…”

Section: Discussioncontrasting

confidence: 77%

Therapeutic effect of two fluoride varnishes on remineralisation of white spot lesions evaluated by laser fluorescence

Knežević¹,

Vojinović²

2022

Scripta Medica

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Background / Aim: The presence of white spot lesion (WSL) is considered the first stage of dental caries. The early detection and diagnosis of WSL is of crucial importance, since caries can be prevented at this stage, reversed and/or controlled by elimination of etiological factors and by use of fluorides. The aim of this study was to compare the efficacy between the two fluoride varnishes on WSL remineralisation evaluated by laser fluorescence. Methods: A total of 30 children and 60 WSL cases (2 per each child) were included in this study. The selected WSL were randomly divided into two groups in each child: G1 applying Fluor Protector S®, Vivadent, Lichenstein (n = 30) and G2 applying MI varnish®, GC, Tokyo, Japan (n = 30). The fluoride varnishes were submitted to three applications: at baseline, four weeks and eight weeks following the baseline, according to the manufacturer's recommendations. Mineral density of the enamel was measured using laser fluorescence (DIAGNOdent® 2095, KaVo, Biberach, Germany) for each WSL. Laser fluorescence (LF) measurements were performed at baseline and at fourth, eighth and twelfth week after starting the treatment and LF scores were calculated. Results: By comparing LF scores at each measurement after treatment initiation, it was found that the scores were significantly lower in all groups when compared to baseline. Conclusion: The results of this study indicate that both fluoride varnishes used were capable of remineralising WSL as evaluated by LF measurements. No difference was noted in the remineralising efficacy of the varnishes despite their different compositions. The main limitations of this study are small sample size and short follow up period. Therefore, further studies with large sample size and a longer follow up are, however, necessary.

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Section: Discussioncontrasting

confidence: 77%

Therapeutic effect of two fluoride varnishes on remineralisation of white spot lesions evaluated by laser fluorescence

Knežević¹,

Vojinović²

2022

Scripta Medica

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“…However, CPP-ACPF varnish did not possess better remineralization potential than Duraphat varnish ( Mohd Said et al, 2017 , Üstün and Aktören, 2019 ). In a clinical investigation conducted by Obradovi et al, CPP ACPF varnish demonstrated superior remineralization versus standard varnish for early smooth surface caries lesions of primary teeth ( Obradović et al, 2016 ). CPP-ACP varnish appears to be equally effective as other fluoride varnishes in remineralizing artificially generated white spot lesions, although the quality of the evidence is low, according to a meta -analysis study ( Nadar et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Efficiency of casein phosphopeptide amorphous calcium phosphate versus topical fluorides on remineralizing early enamel carious lesions – A systematic review and meta analysis

Rahmath Meeral,

Doraikannan,

Indiran

2024

The Saudi Dental Journal

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“…[ 34 38 ] In a clinical trial by Obradović et al ., CPP-ACPF varnish showed better remineralization of initial smooth surface caries lesions of primary teeth compared to conventional varnish with fluoride. [ 50 ] A systematic review and meta-analysis on randomized controlled trials by Tao et al . concluded that fluorides combined with CPP-ACP treatment produce significantly better remineralization of occlusal early caries lesions.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

et al. 2022

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Background: This systematic review aimed to evaluate the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACPF) varnish for remineralization of white spot lesions (WSLs) “ in vitro ” in human teeth. Materials and Methods: Literature search included three databases, namely Medline (via PubMed), The Cochrane Controlled Clinical Trials Register, and Google Scholar from 2010 to January 2021. The studies assessing WSL depth, calcium, phosphate ion release, and microhardness due to artificial demineralization or remineralization were considered for review. Reference articles were retrieved, and a customized risk assessment tool was used. The Cochrane risk of bias assessment tool was used to generate the risk of bias summary graph. Meta-analysis was performed using RevMan 5.4. Heterogeneity was evaluated by Cochrane's test, and random effects model was used to pool estimate of effect and its 95% confidence intervals (CIs) for surface microhardness. Results: Eighteen studies were selected for review based on the eligibility criteria. Four studies showed superior remineralizing effect of CPP-ACPF compared to fluoride varnishes. Four studies involving 120 human permanent teeth samples were included in the meta-analysis. Efficacy of CPP-ACPF varnish was equivalent to other fluoride varnishes in improving surface microhardness after remineralization during 7-day period (mean surface microhardness: 3.94, 95% CI [−9.08–1.21], I 2: 75%, P = 0.13). Major risks of bias associated with the studies included in the review were inadequate sample size, improper sample preparation, and unexplained blinding. Conclusion: CPP-ACPF varnish appears to be equally effective as other fluoride varnishes in remineralizing artificially induced WSLs, but quality of evidence is low.

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The Role of Protective Varnishes in the Treatment of Initial Caries

Cited by 4 publications

References 9 publications

Therapeutic effect of two fluoride varnishes on remineralisation of white spot lesions evaluated by laser fluorescence

Therapeutic effect of two fluoride varnishes on remineralisation of white spot lesions evaluated by laser fluorescence

Efficiency of casein phosphopeptide amorphous calcium phosphate versus topical fluorides on remineralizing early enamel carious lesions – A systematic review and meta analysis

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

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