The Role of Purinergic Receptors in the Circadian System

Ali, Amira A. H.; Avakian, Gayaneh Avanes; Gall, Charlotte von

doi:10.3390/ijms21103423

Cited by 12 publications

(6 citation statements)

References 123 publications

(145 reference statements)

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“…[11][12][13] ATP activates P2X receptors and P2Y 2,11 ; UTP binds to P2Y 2,4 while UDP activates P2Y 6, and ADP stimulates P2Y 1,12,13,14 . 14 In the central nervous system, purinergic receptors show a distinct spatial, 15 and even temporal, 16,17 distribution. The activation of P2 receptors is involved in ion transport, neuro-/gliotransmission, and reorganization of the cytoskeleton and implemented in a wide range of physiological and pathophysiological processes.…”

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confidence: 99%

P2Y ₂ deficiency impacts adult neurogenesis and related forebrain functions

et al. 2021

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In the brain, generation of new neurons throughout life, the adult neurogenesis, has important functional aspects. Adult neurogenesis is a multistep process covering proliferation of neuronal stem/precursor cells (NPCs), migration of neuroblasts, differentiation into mature neurons, and integration into pre-existing neuronal networks. Moreover, neurogenesis is heterogeneous among mammals depending on species and age. 1 Under normal physiological conditions, adult neurogenesis takes place in specific regions of the adult mouse brain, known as "neurogenic niches,"

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P2Y ₂ deficiency impacts adult neurogenesis and related forebrain functions

et al. 2021

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“…The mechanism behind how the P2X7R contributes to seizures and epilepsy remains to be established. The P2X7R has key roles in many physiological processes pertinent to seizure generation as well as epileptogenesis, including synaptic reorganization, the regulation of the BBB, cellular survival, circadian rhythms, neurogenesis, and inflammation [14,16,[138][139][140]. Among these, neuroinflammation has attracted the most attention in the field [26].…”

Section: Targeting Of the P2x7r And Seizure Controlmentioning

confidence: 99%

Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor

Gil

Smith

Tang

et al. 2022

IJMS

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Epilepsy is one of the most common chronic diseases of the central nervous system (CNS). Treatment of epilepsy remains, however, a clinical challenge with over 30% of patients not responding to current pharmacological interventions. Complicating management of treatment, epilepsy comes with multiple comorbidities, thereby further reducing the quality of life of patients. Increasing evidence suggests purinergic signalling via extracellularly released ATP as shared pathological mechanisms across numerous brain diseases. Once released, ATP activates specific purinergic receptors, including the ionotropic P2X7 receptor (P2X7R). Among brain diseases, the P2X7R has attracted particular attention as a therapeutic target. The P2X7R is an important driver of inflammation, and its activation requires high levels of extracellular ATP to be reached under pathological conditions. Suggesting the therapeutic potential of drugs targeting the P2X7R for epilepsy, P2X7R expression increases following status epilepticus and during epilepsy, and P2X7R antagonism modulates seizure severity and epilepsy development. P2X7R antagonism has, however, also been shown to be effective in treating conditions most commonly associated with epilepsy such as psychiatric disorders and cognitive deficits, which suggests that P2X7R antagonisms may provide benefits beyond seizure control. This review summarizes the evidence suggesting drugs targeting the P2X7R as a novel treatment strategy for epilepsy with a particular focus of its potential impact on epilepsy-associated comorbidities.

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“…Wirsching et al made an insightful review of how extracellular ATP and expression of P2X and P2Y receptors within the cells of the distal lung contribute to alveolar function, surfactant secretion, epithelial fluid transport, host defense, and the development/progression of lung diseases such as infectious pneumonia and acute respiratory distress syndrome [ 14 ]. Ali et al summarized recent data about P2X and P2Y receptor expression and function within the suprachiasmatic nucleus, retina, and peripheral circadian oscillators exemplified by urinary bladder, suggesting that interaction between the circadian system and purinergic signaling might play a role in rhythmic body functions under physiological and pathological conditions [ 15 ]. Among the P2X receptors, P2X7 has attracted increasing interest in the field of inflammation and/or immune response as well as in cancer.…”

Section: Reviewmentioning

confidence: 99%