The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

Svineng, Gunbjørg; Ravuri, Chandra Sekhar; Rikardsen, Oddveig G; Huseby, Nils‐Erik; Winberg, Jan‐Olof

doi:10.1080/03008200802143166

Cited by 111 publications

(70 citation statements)

References 64 publications

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“…This mechanism also requires the activity of irg1-like, a second zebrafish homologue of the mammalian Irg1 (36). ROS species can function as signaling molecules to regulate the transcription and activity of various inflammatory mediators, including matrix metalloproteinases (70,92), which contribute to macrophage recruitment during inflammatory processes of the skin (36). However, the mechanisms discovered in these studies have not yet been confirmed in mammalian cells.…”

Section: Subcellular Localization Of Mammalian Cad/irg1mentioning

confidence: 90%

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

2015

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Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. 12.1

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Section: Subcellular Localization Of Mammalian Cad/irg1mentioning

confidence: 90%

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

2015

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“…Integrin signaling also facilitates cell proliferation and migration, which is intimately linked to the degradation of the extracellular matrix, and activated MMPs are a prerequisite for cancer cell invasion (46). We established that the plasma level of MMP9 increases approximately 2 times even in the early stage of cancer development and approximately 3.5 times in the terminal stage (Fig.…”

Section: Discussionmentioning

confidence: 83%

“…The oncogenic miRNAs, secreted by cancer cells into the environment, are considered a primary mediator of this process (44,45). The activation of integrins is linked to additional ROS/RNS production by NADPH oxidases, lipoxygenases, mitochondria, etc., leading to a vicious cycle (46). As a result, the antioxidant defense system crashes with the progression of cancer and tissue redox balance shifts toward oxidation in the intermediate/terminal stage (Fig.…”

Section: Discussionmentioning

confidence: 99%

Tissue Redox Activity as a Hallmark of Carcinogenesis: From Early to Terminal Stages of Cancer

Bakalova

Zhelev

Aoki

et al. 2013

Clinical Cancer Research

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Purpose: The study aimed to clarify the dynamics of tissue redox activity (TRA) in cancer progression and assess the importance of this parameter for therapeutic strategies.Experimental Design: The experiments were carried out on brain tissues of neuroblastoma-bearing, glioma-bearing, and healthy mice. TRA was visualized in vivo by nitroxide-enhanced MRI on anesthetized animals or in vitro by electron paramagnetic resonance spectroscopy on isolated tissue specimens. Two biochemical parameters were analyzed in parallel: tissue total antioxidant capacity (TTAC) and plasma levels of matrix metalloproteinases (MMP).Results: In the early stage of cancer, the brain tissues were characterized by a shorter-lived MRI signal than that from healthy brains (indicating a higher reducing activity for the nitroxide radical), which was accompanied by an enhancement of TTAC and MMP9 plasma levels. In the terminal stage of cancer, tissues in both hemispheres were characterized by a longer-lived MRI signal than in healthy brains (indicating a high-oxidative activity) that was accompanied by a decrease in TTAC and an increase in the MMP2/MMP9 plasma levels. Cancer progression also affected the redox potential of tissues distant from the primary tumor locus (liver and lung). Their oxidative status increased in both stages of cancer.Conclusions: The study shows that tissue redox balance is very sensitive to the progression of cancer and can be used as a diagnostic marker of carcinogenesis. The study also suggests that the noncancerous tissues of a cancer-bearing organism are susceptible to oxidative damage and should be considered a therapeutic target.

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“…Likely, when H2O2 is produced at high concentrations in MDA-MB 231 cells, it may be capable to affect enzymatic activities by altering signaling pathways and even cause cellular damage. Many elements in the process leading to cell migration are considered to be redox-sensitive (Pani et al, 2009;Svineng et al, 2008). ROS modify the activity of several key enzymes, resulting in the reorganization of actin cytoskeleton, adhesion and stimulation of migration.…”

Section: Cell Migration Is Influenced By H2o2 Levelsmentioning

confidence: 99%

Histamine and Breast Cancer: A New Role for a Well Known Amine

Cricco¹,

Mohamad²,

Sáez³

et al. 2011

Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways

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The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

Cited by 111 publications

References 64 publications

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Tissue Redox Activity as a Hallmark of Carcinogenesis: From Early to Terminal Stages of Cancer

Histamine and Breast Cancer: A New Role for a Well Known Amine

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