The Role of Single Nucleotide Polymorphism +45t/G of Adiponektin Gene (Adipoq) in Risk of Type Ii Diabetes Mellitus Development

Abstract

Single nucleotide polymorphism (SNP) +45T/G gene of adiponectin (ADIPOQ) in type 2 diabetes mellitus patients and in healthy residents of Kharkiv has been taken into consideration. Frequencies of SNP +45T/G for patients (pG = 0,48; pT = 0,52) and healthy residents(pG = 0,49; pT = 0,51) do not differ significantly. The genotypes frequency in control group doesn’t correspond to HardyWeinberg equilibrium: the share of heterozygotes +45T/G is 1,8 times higher than selectively-neutral value. The type II diabetes mellitus patients have the share of heterozygotes +45T/G one third lower than in control group. The analysis has shown that heterozygotes genotype reduces the risk of type 2diabetes mellitus in seven times (p < 0,05) in comparison with a mean value in population.