The role of small intestinal bacterial overgrowth in obesity and its related diseases

Yao, Qinyan; Yu, Zihan; Meng, Qing-Hao; Chen, Jihua; Liu, Yaxin; Song, Wenhui; Ren, Xiangfeng; Zhou, Junhu; Chen, Xin

doi:10.1016/j.bcp.2023.115546

Cited by 6 publications

(6 citation statements)

References 129 publications

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“…The deregulation of any of these protective mechanisms can lead to microbiota dysbiosis, a potential pathway for the development of Small Intestinal Bacterial Overgrowth (SIBO) [ 2 , 3 ]. SIBO is characterized by increased colonization of anaerobic and aerobic microorganisms within the small intestine, predominantly Gram-negative species including Klebsiella pneumoniae, Escherichia coli , Streptococcus gramineus , Prevotella , Clostridium spp, and Methanobrevibactersmithii [ 4 , 5 , 6 ]. Depending on the dominant composition of the bacterial overgrowth, the production of gases as a result of bacterial fermentation, such as hydrogen (H 2 ), methane (CH 4 ), or hydrogen sulfide (H 2 S) is observed.…”

Section: Introductionmentioning

confidence: 99%

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Wielgosz-Grochowska,

Domanski,

Drywień

2023

Nutrients

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Recent observations have shown that Small Intestinal Bacterial Overgrowth (SIBO)affects the host through various mechanisms. While both weight loss and obesity have been reported in the SIBO population due to alterations in the gut microbiome, very little is known about the influence of SIBO type on body composition. This study aimed to evaluate whether there is a link between the three types of SIBO: methane dominant (M+), hydrogen dominant (H+), and methane–hydrogen dominant (H+/M+) and specific anthropometric parameters. This observational study included 67 participants (W = 53, M = 14) with gastrointestinal symptoms and SIBO confirmed by lactulose hydrogen–methane breath tests (LHMBTs) using the QuinTron device. Participants underwent a body composition assessment by Bioelectrical Impedance Analysis (BIA) using the InBody Analyzer. In the H+/M+ group, body weight (p = 0.010), BMI (p = 0.001), body fat in kg (p = 0.009), body fat in % (p = 0.040), visceral fat (p = 0.002), and mineral bone content (p = 0.049) showed an inverse correlation with hydrogen (H2) gas production. These findings suggest that body weight, BMI, body fat, and mineral bone content may be inversely linked to the production of hydrogen and the risk of hydrogen–methane SIBO.

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Section: Introductionmentioning

confidence: 99%

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Wielgosz-Grochowska,

Domanski,

Drywień

2023

Nutrients

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“…The prevalence of excess weight and obesity in the United States and Europe has climbed almost unabated in the last 50 years, leading to an increase in chronic diseases such as cancer, cardiovascular disease, type 2 diabetes, hypertension and coronary heart disease [1][2][3][4]. The role of diet and physical activity in mitigating the risk of obesity have gained much attention, justifiably, given that deaths can increasingly be attributed to excess weight, caused by poor diet and physical inactivity [3,8,44,45]. Overweight people tend to ingest glucose-containing foods, which can lead to glucose addiction, increased glucose levels in the blood and intestine lumen, and exposure of intestinal epithelial (IE) cells to high glucose (HG) concentrations.…”

Section: Discussionmentioning

confidence: 99%

High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties

Dubois,

Muñoz-Garcia,

Heymann

et al. 2023

Biochemical Pharmacology

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“…Notably, dysbiosis of the gut microbiota has been observed in patients with T2DM and NAFLD, highlighting its association with these conditions. 16,17 Therefore, it is plausible that SGLT2 inhibitors attenuate liver fibrosis by modulating the gut microbiota. However, the interactions among SGLT2 inhibitors, gut microbiota and liver fibrosis remain unclear and necessitate further investigation.…”

Section: Introductionmentioning

confidence: 99%

Empagliflozin attenuates liver fibrosis in high‐fat diet/streptozotocin‐induced mice by modulating gut microbiota

Huang,

Qian,

Liu

et al. 2024

Clin Exp Pharma Physio

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The effects of SGLT2 inhibitors on hepatic fibrosis in diabetes remain unclear. This study aimed to investigate the effects of empagliflozin on liver fibrosis in high‐fat diet/streptozotocin‐induced mice and the correlation with gut microbiota. After the application of empagliflozin for 6 weeks, we performed oral glucose tolerance and intraperitoneal insulin tolerance tests to assess glucose tolerance and insulin resistance, and stained liver sections to evaluate histochemical and hepatic pathological markers of liver fibrosis. Moreover, 16S rRNA amplicon sequencing was performed on stool samples to explore changes in the composition of intestinal bacteria. We finally analysed the correlation between gut microbiome and liver fibrosis scores or indicators of glucose metabolism. The results showed that empagliflozin intervention improved glucose metabolism and liver function with reduced liver fibrosis, which might be related to changes in intestinal microbiota. In addition, the abundance of intestinal probiotic Lactobacillus increased, while Ruminococcus and Adlercreutzia decreased after empagliflozin treatment, and correlation analysis showed that the changes in microbiota were positively correlated with liver fibrosis and glucose metabolism. Overall, considering the contribution of the gut microbiota in metabolism, empagliflozin might have improved the beneficial balance of intestinal bacteria composition. The present study provides evidence and indicates the involvement of the gut–liver axis by SGLT2 inhibitors in T2DM with liver fibrosis.

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The role of small intestinal bacterial overgrowth in obesity and its related diseases

Cited by 6 publications

References 129 publications

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties

Empagliflozin attenuates liver fibrosis in high‐fat diet/streptozotocin‐induced mice by modulating gut microbiota

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