The Role of Soft Tissues in Osteogenesis

Hurley, Lloyd A.; Stinchfield, Frank E.; Bassett, C. Andrew L.; Lyon, William H.

doi:10.2106/00004623-195941070-00007

Cited by 119 publications

(29 citation statements)

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“…Считается, что мышечный трансплантат на питающей ножке резорбирует некротический детрит, выступая в роли дренажа, однако у детей при хроническом гематогенном остеомиелите не наблюдается выраженного гнойного расплавления тканей, очаг обычно ограничен зоной склероза и не нуждается в активном дренировании. В от-даленные сроки происходит замещение мышечной ткани не костной, а соединительной, формируется так называемый фиброзно-пластический барьер остеогенеза [13,14,17], который снижает репара-тивные способности кости.…”

Section: Discussionunclassified

Comprehensive Treatment of Chronic Osteomyelitis in Children With Immunological Guidance

Снетков

Игоревич²,

Simonova³

et al. 2014

Pediatr Traum Orthop Reconstr Surg

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Резюме. Представлены результаты комплексного обследования и лечения детей с хроническим остеомиелитом в возрасте от 7 месяцев до 18 лет. Определена методика использования различных форм КоллапАна. Малоинвазивность метода применения КоллапАн-геля позволяет выполнить оперативное вмешательство при расположении очага вблизи зоны роста. Практически у всех детей выявлены сопутствующие соматические заболевания, латентная бактериально-вирусная инфекция. В связи с чем оперативное вмешательство необходимо дополнять полноценным лечением сопутствующей патологии.Ключевые слова: хронический остеомиелит, дети, КоллапАн, бактериально-вирусная инфекция.

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Section: Discussionunclassified

Comprehensive Treatment of Chronic Osteomyelitis in Children With Immunological Guidance

Снетков

Игоревич²,

Simonova³

et al. 2014

Pediatr Traum Orthop Reconstr Surg

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“…This phenomenon leads to scar formation at the site of wound healing without bone formation. To avoid these problems, the use of barrier membranes to facilitate bone healing was developed (3,13), and then tested in different types of bone defects and dental implants, both experimentally and clinically (5,7,26). Even though membranes are used to treat bone defects, larger defects are usually not fi lled with sufficient bone tissues.…”

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confidence: 99%

Bone formation in .BETA.-tricalcium phosphate-filled bone defects of the rat femur: Morphometric analysis and expression of bone related protein mRNA

et al. 2005

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The purpose of the current study was to evaluate the bone formation when β-tricalcium phosphate (TCP) was implanted in bone defects of rat femurs. β-TCP granules were applied to defects created in the femurs of 65 male rats who were sacrifi ced 3, 7, 10, 14 or 30 days later. Bone tissues were embedded in paraffi n, serial sections were cut and then stained with hematoxylin-eosin. Histomorphometric analyses were also conducted. Furthermore, total mRNAs were extracted, homogenized, and reverse transcribed, after which quantitative PCR assays were conducted with a LightCycler™ using the double-stranded DNA dye Syber Green I with primers for either rat osteopontin or osteocalcin. Tissues in defects without β-TCP were used as controls. The amount of newly formed bone tissue in the β-TCP implanted group was signifi cantly greater in both the side areas and the central area of defects than in the control group. Expressions of osteopontin and osteocalcin mRNAs of cells in the defects of the experimental group were up-regulated compared with the control group at all time periods. Taken together, these results prove that β-TCP is an appropriate material for osteoconduction and promotes bone formation in bone defects.

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“…High failure rates have been reported resulting from: poor vascularity in a scarred fusion bed, 13 inadequate posterior bony surface area, 14 loss of sagittal alignment, 14,15 and exposure to adverse systemic factors such as nicotine. 16 However, to date, there are no published animal models of pseudarthrosis repair.…”

mentioning

confidence: 99%

Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis

Grauer

Vaccaro²,

Kato³

et al. 2004

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The Role of Soft Tissues in Osteogenesis

Cited by 119 publications

References 0 publications

Comprehensive Treatment of Chronic Osteomyelitis in Children With Immunological Guidance

Comprehensive Treatment of Chronic Osteomyelitis in Children With Immunological Guidance

Bone formation in .BETA.-tricalcium phosphate-filled bone defects of the rat femur: Morphometric analysis and expression of bone related protein mRNA

Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis

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