The Role of Some Biomarkers for Diagnosis of Coronavirus Infection in Diyala Province

Abstract

One of the main viruses that affect people, the Coronavirus, primarily targets the respiratory system. Animals could also be infected by Coronaviruses causing a group of respiratory and gastrointestinal severe diseases. After severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third epidemic coronavirus. SARS-CoV-2 causes Coronavirus Disease 2019 or what so called (COVID-19). Since its first confirmation in December 2019, the spreading of COVID-19 has generated a great interest in all the world. Patients who are severely infected with COVID-19 are susceptible to hyper inflammation (HI), that accompanied biomarkers (BMs) could be useful for risk stratification (RS). Aim and Objective of the Study:The aim of the presented study is to identify some BMs including: Interleukin-6 (IL)-6, Lactate Dehydrogenase Hormone (LDH), D-dimer, Procalcitonin (PCT), Ferritin, and C-reactive protein (CRP), in patients infected with SARS-CoV-2. Materials and Methods:Serum samples were taken from patients in Diyala Governorate-Iraq during the period of January to April 2021. After detection of the virus through using of real time-PCR technique, the level of the BMs in study groups have been measured. Results:The current study revealed highly significant relationship between some of the studied BMs in the mean concentrations in the serum of the patients and control group. Conclusion:The studied BMs have been accompanied with poor outcomes. They could be the main concerns for RS models in testing of severe COVID-19 (S-COVID-19) and guiding the appropriate clinical care.