One of the main viruses that affect people, the Coronavirus, primarily targets the respiratory system. Animals could also be infected by Coronaviruses causing a group of respiratory and gastrointestinal severe diseases. After severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third epidemic coronavirus. SARS-CoV-2 causes Coronavirus Disease 2019 or what so called (COVID-19). Since its first confirmation in December 2019, the spreading of COVID-19 has generated a great interest in all the world. Patients who are severely infected with COVID-19 are susceptible to hyper inflammation (HI), that accompanied biomarkers (BMs) could be useful for risk stratification (RS). Aim and Objective of the Study:The aim of the presented study is to identify some BMs including: Interleukin-6 (IL)-6, Lactate Dehydrogenase Hormone (LDH), D-dimer, Procalcitonin (PCT), Ferritin, and C-reactive protein (CRP), in patients infected with SARS-CoV-2. Materials and Methods:Serum samples were taken from patients in Diyala Governorate-Iraq during the period of January to April 2021. After detection of the virus through using of real time-PCR technique, the level of the BMs in study groups have been measured. Results:The current study revealed highly significant relationship between some of the studied BMs in the mean concentrations in the serum of the patients and control group. Conclusion:The studied BMs have been accompanied with poor outcomes. They could be the main concerns for RS models in testing of severe COVID-19 (S-COVID-19) and guiding the appropriate clinical care.