The role of speed versus working memory in predicting learning new information in multiple sclerosis

Chiaravalloti, Nancy D.; Stojanovic-Radic, Jelena; DeLuca, John

doi:10.1080/13803395.2012.760537

Cited by 56 publications

(52 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Importantly, deficits in complex WM and PS were noted in the current sample. Such deficits have been shown to negatively affect the learning and memory process in other neurologically impaired populations . However, correlational analyses conducted on the current data revealed no significant relationship between learning and memory performance, PS deficits, and complex WM deficits in the current sample.…”

Section: Discussioncontrasting

confidence: 77%

“…Such deficits have been shown to negatively affect the learning and memory process in other neurologically impaired populations. 45,48 However, correlational analyses conducted on the current data revealed no significant relationship between learning and memory performance, PS deficits, and complex WM deficits in the current sample. This indicates that the learning deficit observed herein could reflect a hippocampally mediated learning deficit that is potentially amenable to cognitive rehabilitation focused specifically on learning.…”

Section: H I a R A V A L L O T I E T A Lcontrasting

confidence: 61%

See 1 more Smart Citation

The source of the memory impairment in Parkinson's disease: Acquisition versus retrieval

et al. 2014

Self Cite

View full text Add to dashboard Cite

Memory deficits are common in persons with Parkinson's disease (PD) even without the presence of a frank dementia. These memory deficits have traditionally been attributed to inability of patients to retrieve information from long‐term memory, referred to as the “retrieval failure hypothesis.” However, some studies additionally document problems in recognition memory, noted to be inconsistent with the retrieval failure hypothesis. Given the neuroanatomical abnormalities observed in the hippocampus of PD patients and the role of the hippocampus in learning new information, the current study was designed to specifically examine learning abilities in a nondemented PD sample through the application of a learning paradigm, the Open Trial Selective Reminding Test. We examined 27 patients with PD without dementia and 27 age‐, gender‐, and education‐matched healthy controls (HCs) with a neuropsychological test battery designed to assess new learning and memory. Results indicated a significant difference between the groups in terms of their ability to learn a list of 10 semantically related words. However, once the groups were equated on learning abilities, no significant difference was noted between the PD and HC participants in recall or recognition of the newly learned material. The memory deficit observed in nondemented PD patients is thus largely the result of a deficit in learning new information. This finding should be used to guide treatment for memory deficits in persons with PD, and future research should seek to identify novel means of improving new learning in this population. © 2014 International Parkinson and Movement Disorder Society

show abstract

Section: Discussioncontrasting

confidence: 77%

Section: H I a R A V A L L O T I E T A Lcontrasting

confidence: 61%

The source of the memory impairment in Parkinson's disease: Acquisition versus retrieval

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…We also found a significant correlation between the delayed improvement and processing speed, measured with the SDMT, the retroactive interference and the primacy recall only in this MS subgroup. Interactions between processing speed and verbal learning have been frequently reported in MS, these patients needing more trials to learn the same amount of information as controls [42][43][44][45][46]57] and the spaced learning trials being a successful method in MS memory rehabilitation [3,32,46]. Here, we can hypothesize that a slower processing speed may explain the memory profile of the improving subgroup.…”

Section: Discussionmentioning

confidence: 73%

“…Their interference sensitivity may be increased by both the non-stabilization of their memory trace for the first list and the addition of new items (difficult to learn in a single trial according to their short-term impairment). If these hypotheses account correctly for the situation, the improving subgroup may be help by spaced learning, as previously shown in MS [3,32,46]. The present study would provide a way to select patients likely to benefit from this temporal rehabilitation based on their performances in a classical clinical test (the CVLT).…”

Section: Discussionmentioning

confidence: 94%

“…Some authors are operationalized this deficit as a pathological score for both cued recalls and delayed recognition [28,26], although a storage deficit could also explain this long-term profile. For others, encoding refers either to the first recallT1 [21,[38][39][40][41] which corresponds to the change of information from sensory input into a form that the memory system can store, or to the evolution throughout the first five trials (learning or acquisition), which corresponds to the change resulting from practice [9,16,27,[42][43][44][45][46]. Our individual results point to the existence of both these latter deficits, with encoding deficits being three times more common than learning deficits (58% and 19% of MS patients respectively).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?

Amaya¹,

Bakchine²,

Igor³

2013

J Mult Scler

View full text Add to dashboard Cite

Objective: Various verbal episodic memory impairments have been demonstrated in multiple sclerosis (MS), including encoding, retrieval and storage processes. Our clinical experiment suggests that a subset of MS patients may show another pattern with a distinctive evolution of performances after a 20 minutes delay (short-delay versus long-delay free recall). Methods:The current study assessed performances on the California Verbal Learning Test (CVLT) in MS with a special focus on evolution after delay to identify a subgroup of patients who may show a significant spontaneous improvement of long-delay free recall in comparison with short-delay free recall. Data from 52 MS patients were compared with those from 32 controls. Group analyses were conducted on classical scores. Individual MS performances were also analyzed, according to confidence intervals calculated using control data.Results: From individual analysis, memory comorbidities were frequently observed in a MS patient (17% of MS patients had only one impaired score, 17% had two or three scores, 27% had four or five scores and 38% had six or more). Regarding the evolution after delay, three profiles were highlighted: two classical (stable and worsening, i.e. storage deficit) and a third showing a significant degree of improvement. The improvement was significantly correlated with processing speed, primacy effect and sensitivity to retroactive interference only in this third MS subgroup. This benefit from delay was not related to the effect of semantic clustering. Conclusion:The current study suggests that a subgroup of MS patients might present a previously unreported abnormal long-term memory profile, in which an impaired short-term performance contrasts with a significant spontaneous improvement with delay. Previous studies have demonstrated the relevance of spaced learning in MS rehabilitation. If our results are corroborated in a larger sample, the CVLT may help to select patients that are likely to benefit from this temporal memory care.

show abstract

The efficacy of speed of processing training for improving processing speed in individuals with multiple sclerosis: a randomized clinical trial

et al. 2022

View full text Add to dashboard Cite

The role of speed versus working memory in predicting learning new information in multiple sclerosis

Cited by 56 publications

References 66 publications

The source of the memory impairment in Parkinson's disease: Acquisition versus retrieval

The source of the memory impairment in Parkinson's disease: Acquisition versus retrieval

Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?

The efficacy of speed of processing training for improving processing speed in individuals with multiple sclerosis: a randomized clinical trial

Contact Info

Product

Resources

About