The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neck region: Review of 30 cases

Fayda, Merdan; Aksu, Görkem; Ağaoğlu, Fulya Yaman; Karadeniz, Ahmet; Darendeliler, Emin; Altun, Musa; Hafız, Günter

doi:10.1016/j.jcms.2008.07.007

Cited by 47 publications

(34 citation statements)

References 25 publications

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“…Fayda et al 19 studied 30 cases and focused on the roles of surgery and radiotherapy in the treatment of soft-tissue sarcomas of the head and neck during an average follow-up time of 31 months. They found a statistically significant difference in the overall survival rate of patients who were treated with surgery and radiotherapy.…”

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confidence: 99%

Prognostic factors in patients with jaw sarcomas

2011

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The aim of this study was to identify the prognostic factors related to the survival of patients with sarcomas of the jaw treated in the Dr. Eduardo Caceres Graziani National Institute for Neoplastic Diseases, Lima, Peru. Age, gender, delay in consultation, diagnostic delay, therapeutic delay, tumor size, tumor location, facial asymmetry, pain, treatment type, and histopathological diagnosis were all evaluated as possible prognostic factors that would influence survival in those with jaw sarcomas. In the analysis, the following was used: mortality tables, KaplanMeier's product-limit method, log-rank, and Breslow and Tarone-Ware tests; for the prognostic factors, Cox's Regression Model was used. The overall survival rate, with the patient being free from disease at two years, was 55%, and that at five years was 45%. In the independent analysis of the prognostic factors, four variables were statistically significant in influencing survival: gender (p = 0.043), histopathologic diagnosis (p = 0.019), tumor location (p = 0.019), and treatment type (p = 0.030). According to Cox's Regression Model for the multivariate analysis, statistically significant prognostic factors were: gender (p = 0.086), tumor location (p = 0.020), and treatment type (p = 0.092). Thus, the variables of gender, tumor location, and treatment type were determined to be predictive factors for prognosis of survival.

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confidence: 99%

Prognostic factors in patients with jaw sarcomas

2011

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“…The high recurrence rate may be attributed to the difficulty of obtaining sufficient surgical margins, although a positive surgical margin is an important factor leading to local failure [1,4,6]. Radiotherapy is indicated for patients with close or positive margins or for unresectable tumors [5,7]. Systemic chemotherapy is widely used as the primary treatment in metastatic disease, as adjuvant treatment, or as neoadjuvant therapy to determine the responsiveness of regimens.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic chemotherapy is widely used as the primary treatment in metastatic disease, as adjuvant treatment, or as neoadjuvant therapy to determine the responsiveness of regimens. Adriamycin, cyclophosphamide, and ifosfamide are the most commonly prescribed drugs in this therapeutic management [5,7]. Postoperative radiotherapy and chemotherapy have been proven to enhance local control but are not effective for improving the overall survival.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, tumors larger than 3 cm, tumors originating in the bone, high-grade tumors, and giant cell-type MFH were described as poor prognostic factors [4,5,7]. In conclusion, although various strategies of palliative treatment have been reported in patients with metastatic MFH of the maxillary sinus, the outcomes have been extremely disappointing [6,9].…”

Section: Discussionmentioning

confidence: 99%

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Unusual hematogenous brain metastasis in malignant fibrous histiocytoma of the maxillary sinus

Shih

Huang

et al. 2011

Int J Clin Oncol

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Malignant fibrous histocytoma (MFH) of the maxillary sinus is believed to be a rare form of soft tissue sarcoma with a low frequency of distant metastasis. In this study, we provide a histological documentation of the hematogenous spread of MFH to the brain and report a case of maxillary sinus MFH with unusual metastasis to the brain. To our knowledge, this is the first case of a direct histological diagnosis of maxillary sinus MFH with brain metastasis via a hematogenous route.

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“…Besides, high local relapse rates, between 20% and 25%, have been observed in patients treated exclusively by surgery [3,4]. This is why radiotherapy is commonly used in patients with high-grade tumors or positive margins [5]. When surgery is impossible or refused, treatment generally combines radiotherapy and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Head and neck sarcoma: report of a case treated by intensity-modulated radiation therapy

et al. 2010

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We report on a 71-year-old woman with parapharyngeal sarcoma. Surgery could not be performed because of the size and location of the tumor. After failure of four cycles of chemotherapy, intensity-modulated radiation therapy (IMRT) achieved complete clinical response and partial magnetic resonance imaging response (80%) at 24 months of follow-up. The results of radiotherapy, especially IMRT, for nonresectable head and neck soft tissue sarcoma are discussed.

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The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neck region: Review of 30 cases

Cited by 47 publications

References 25 publications

Prognostic factors in patients with jaw sarcomas

Prognostic factors in patients with jaw sarcomas

Unusual hematogenous brain metastasis in malignant fibrous histiocytoma of the maxillary sinus

Head and neck sarcoma: report of a case treated by intensity-modulated radiation therapy

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