The role of the immune system in preeclampsia

Saito, Shigeru; Shiozaki, Arihiro; Nakashima, Akitoshi; Sakai, Masatoshi; Sasaki, Yasushi

doi:10.1016/j.mam.2007.02.006

Cited by 293 publications

(249 citation statements)

References 102 publications

Supporting

Mentioning

232

Contrasting

Unclassified

Order By: Relevance

“…The inadequate production of transforming growth factor-b by leukocytes may cause poor angiogenesis, resulting in preeclampsia. 8 AHSG, similar to soluble endoglin, can inhibit transforming growth factor-b activity. 58 Insulin resistance is a definite risk factor for preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 The systemic inflammatory response involves a rise in the number and activation of leukocytes (monocytes, granulocytes and natural killer cells) with the production of proteases and proinflammatory cytokines leading to T-helper type 1 bias, as well as the activation of endothelial cells, platelets, the coagulation and complement systems and the production of acute-phase proteins. [5][6][7][8] The development of preeclampsia is influenced by both genetic and environmental risk factors, suggesting its multifactorial inheritance. [9][10][11][12][13][14] The a 2 -Heremans-Schmid (a 2 -HS) glycoprotein (fetuin-A, AHSG), the human homolog of bovine fetuin, is an abundant plasma/serum protein synthesized predominantly by hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

et al. 2009

View full text Add to dashboard Cite

The purpose of this study was to determine serum a 2 -HS glycoprotein (AHSG) concentration and its diagnostic accuracy in preeclampsia. In this case-control study, the serum C-reactive protein (CRP) and AHSG levels were measured in 93 preeclamptic patients and in 127 healthy pregnant women by immunoturbidimetry and radial immunodiffusion. The serum CRP levels were significantly higher, whereas the serum AHSG concentrations were significantly lower in the preeclamptic group than in the control group (median (25th to 75th percentile), CRP: 6.71 mg l À1 (2.76-12.69) vs. 3.38 mg l À1 (1.69-7.27), respectively; AHSG: 660 lg ml À1 (612-768) vs. 744 lg ml À1 (660-816), respectively; Po0.001 for both). In preeclamptic patients, the serum AHSG concentrations showed significant inverse correlations with systolic blood pressure and serum CRP levels. A low serum AHSG level (p720 lg ml À1 ) was significantly associated with preeclampsia (adjusted odds ratio (95% confidence interval): 3.69 (1.82-7.51); Po0.001). According to the receiver operating characteristic curves, the measurement of serum AHSG concentrations was as accurate as that of serum CRP levels to detect preeclampsia. In conclusion, serum AHSG concentration is decreased and reflects-at least partly-systemic inflammation in preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

et al. 2009

View full text Add to dashboard Cite

show abstract

“…PE is a multisystem disorder of pregnancy, which is characterised by new onset hypertension and proteinuria that develop after 20 weeks of gestation in previously normotensive women [2,3]. The disorder has a higher incidence among nulliparous women, in women who conceive with assisted reproduction techniques, and in women affected by autoimmune disorders, reflecting the probable influence of an "inexperienced" or dysregulated maternal immune system in its emergence [4,5]. On the other hand, women with pre-existing metabolic, vascular or renal disease are especially at increased risk for superimposed PE [6].…”

Section: Introductionmentioning

confidence: 99%

Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Agarwal

Gupta

Vishnu

et al. 2014

JCDR

View full text Add to dashboard Cite

show abstract

“…Decreased PAI-2 expression was associated with pre-eclampsia (30), whereas expression was up-regulated in asthma (31), periodontal disease (32), and hyperkeratotic corn tissue (33). PAI-2 polymorphisms have also been associated with antiphospholipid syndrome (34), lupus (35), and myocardial infarction in some (36) but not other studies (37), and all of these diseases have been associated with increased Th1 responses (29,38). The ability of PAI-2 to inhibit the proteolytic activity of proteasome may explain the significance of this serpin for controlling the Th1-promoting cytokine production by macrophages.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasminogen Activator Inhibitor Type 2 (PAI-2) with Proteasome within Endothelial Cells Activated with Inflammatory Stimuli

Boncela

Przygodzka

Papiewska-Pająk

et al. 2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

Quiescent endothelial cells contain low concentrations of plasminogen activator inhibitor type 2 (PAI-2). However, its synthesis can be rapidly stimulated by a variety of inflammatory mediators. In this study, we provide evidence that PAI-2 interacts with proteasome and affects its activity in endothelial cells. To ensure that the PAI-2⅐proteasome complex is formed in vivo, both proteins were coimmunoprecipitated from endothelial cells and identified with specific antibodies. The specificity of this interaction was evidenced after (a) transfection of HeLa cells with pCMV-PAI-2 and coimmunoprecipitation of both proteins with anti-PAI-2 antibodies and (b) silencing of the PAI-2 gene using specific small interfering RNA (siRNA). Subsequently, cellular distribution of the PAI-2⅐proteasome complexes was established by immunogold staining and electron microscopy analyses. As judged by confocal microscopy, both proteins appeared in a diffuse cytosolic pattern, but they also could be found in a dense perinuclear and nuclear location. PAI-2 was not polyubiquitinated, suggesting that it bound to proteasome not as the substrate but rather as its inhibitor. Consistently, increased PAI-2 expression (a) abrogated degradation of degron analyzed after cotransfection of HeLa cells with pCMV-PAI-2 and pd2EGFP-N1, (b) prevented degradation of p53, as evidenced both by confocal microscopy and Western immunoblotting, and (c) inhibited proteasome cleavage of specific fluorogenic substrate. This suggests that PAI-2, in endothelial cells induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling. Plasminogen activator inhibitor type-2 (PAI-2)2 has both extracellular and intracellular functions and acts as a multifunctional protein (1, 2). It exists predominantly as a 47-kDa nonglycosylated intracellular form (3). Due to the lack of an N-terminal signal peptide, only a small percentage of PAI-2 is exported from cells, by the nonclassical secretory pathway, as a glycosylated 60-kDa form (4). PAI-2 contains a unique domain bridging helices C and D, called the C-D loop (5), which directly interacts with different proteins, including retinoblastoma protein (6), proteasome subunit member ␤1 (7), interferon response factor 3 (8), ZNF198/FGFR1 fusion kinase (9), annexins (10), pre-mRNA processing factor 8 (7), and vitronectin (11).The primary physiological function of PAI-2 is thought to be the regulation of plasminogen activators in the extravascular compartment (1, 12). However, such a role is not supported by studies using PAI-2 Ϫ/Ϫ mice that show no discernable defects in fibrinolysis (13). Covalent PAI-2⅐uPA complexes, readily formed in vitro, have also never been unequivocally demonstrated in vivo (14). On the other hand, PAI-2 has been proposed to play a role in different processes, including tumor metastasis, embryo implantation, and macrophage survival (1, 2, 15). Consistently, a broad range of activities were ascribed to PAI-2, such as protection of the retinoblastoma protein f...

show abstract

The role of the immune system in preeclampsia

Cited by 293 publications

References 102 publications

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Association of Plasminogen Activator Inhibitor Type 2 (PAI-2) with Proteasome within Endothelial Cells Activated with Inflammatory Stimuli

Contact Info

Product

Resources

About