The role of the primitive mesothelium in the development of the mammalian spleen

Holyoke, Edward A.

doi:10.1002/ar.1090650307

Cited by 17 publications

(5 citation statements)

References 15 publications

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“…The spleen is characterized as a bulge in the dorsal mesogastrium (DM) in a five‐week embryo or approximately 8 mm of crown‐rump length (Ono, ; Holyoke, ). The developmental process of the spleen can be divided into two stages (Ono, ; Weiss, ; Weiss and Chen, ).…”

Section: Introductionmentioning

confidence: 99%

Morphogenesis of the Spleen During the Human Embryonic Period

Endo

Ueno

Yamada

et al. 2014

The Anatomical Record

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We aimed to observe morphological changes in the spleen from the emergence of the primordium to the end of the embryonic period using histological serial sections of 228 samples. Between Carnegie stages (CSs) 14 and 17, the spleen was usually recognized as a bulge in the dorsal mesogastrium (DM), and after CS 20, the spleen became apparent. Intrasplenic folds were observed later. A high-density area was first recognized in 6 of the 58 cases at CS 16 and in all cases examined after CS 18. The spleen was recognized neither as a bulge nor as a high-density area at CS 13. The mesothelium was pseudostratified until CS 16 and was replaced with high columnar cells and then with low columnar cells. The basement membrane was obvious after CS 17. The mesenchymal cells differentiated from cells in the DM, and sinus formation started at CS 20. Hematopoietic cells were detected after CS 18. The vessels were observed at CS 14 in the DM. Hilus formation was observed after CS 20. The parallel entries of the arteries and veins were observed at CS 23. The rate of increase in spleen length in relation to that of stomach length along the cranial-caudal direction was 0.51 6 0.11, which remained constant during CSs 19 and 23, indicating that their growths were similar. These data may help to better understand the development of normal human embryos and to detect abnormal embryos in the early stages of development. Anat Rec, 298:820-826, 2015. V C 2014 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Morphogenesis of the Spleen During the Human Embryonic Period

Endo

Ueno

Yamada

et al. 2014

The Anatomical Record

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“…There are several theories attempting to explain the embryogenesis of these aberrant structures, which are generally agreed to be of mesodermal origin (Holyoke, 1936). The time of appearance of the splenic anlage appears to be fairly constant and it has been found in human embryos 7.5-8 mm in length (Holyoke).…”

Section: Discussionmentioning

confidence: 99%

The significance of the accessory spleen

Cahalane

Kiesselbach

1970

The Journal of Pathology

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“…(3) Peritoneal epithelium is a separate structure, embryonally and definitively (Stout and Murray, 1942;Chlopin, 1931;Iversen, 1957), and under no circumstance should it be considered as a layer of flattened fibroblasts or even mesenchymal cells of the conventional type (FIGURE 9). As so many investigators have done in the past (Lewis, 1923a(Lewis, , 1923bSchott and Weidenreich, 1909;Cunningham, 1922a;Clarke, 1915Clarke, -1916Holyoke, 1936).…”

Section: Introductionmentioning

confidence: 99%

“…In a human embryo of the seventh week the primitive spleen consists of a close-meshed epithelioid network of cells in anatomical continuity with the peritoneal epithelium (see FIGURES 8 and 12; Thiel and Downey, 1921 ;Holyoke, 1936) and is the primitive reticulum cell population or initial splenic parenchyma (Thiel and Downey, 1921;Holyoke, 1936). According to Thiel and Downey (1921) and the majority of others it becomes transformed directly into the fixed reticulum cell component of the definitive spleen.…”

Section: Introductionmentioning

confidence: 99%

SOME IN VITRO AND IN VIVO STUDIES ON SEVERAL MESENCHYMAL CELL TYPES BEARING ON THE PROBLEM OF THE RETICULOENDOTHELIAL SYSTEM

Richter

1958

Annals of the New York Academy of Sciences

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The role of the primitive mesothelium in the development of the mammalian spleen

Cited by 17 publications

References 15 publications

Morphogenesis of the Spleen During the Human Embryonic Period

Morphogenesis of the Spleen During the Human Embryonic Period

The significance of the accessory spleen

SOME IN VITRO AND IN VIVO STUDIES ON SEVERAL MESENCHYMAL CELL TYPES BEARING ON THE PROBLEM OF THE RETICULOENDOTHELIAL SYSTEM

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