The role of the saliva antioxidant barrier to reactive oxygen species with regard to caries development

Jurczak, Anna; Kościelniak, Dorota; Skalniak, Anna; Papież, Monika; Vyhouskaya, Palina; Krzyściak, Wirginia

doi:10.1080/13510002.2017.1301625

Cited by 21 publications

(31 citation statements)

References 34 publications

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“…Nonetheless, both values were higher than the protein concentration measured in cariesfree children (1.65 mg/mL). It must be pointed out that salivary protein concentrations quantified in the different groups included in the study by Jurczak et al in 2017 [31] were almost two-fold higher than in the present study. This is probably because Jurczak et al in 2017 used chewstimulated saliva samples, which are associated with increased protein values as compared to nonstimulated saliva [31].…”

Section: Discussioncontrasting

confidence: 69%

“…It must be pointed out that salivary protein concentrations quantified in the different groups included in the study by Jurczak et al in 2017 [31] were almost two-fold higher than in the present study. This is probably because Jurczak et al in 2017 used chewstimulated saliva samples, which are associated with increased protein values as compared to nonstimulated saliva [31]. In contrast, Tulunoglu et al in 2006 [13] reported that salivary protein values in children aged 7-10 years old (6.5 mg/mL) did not significantly differ from salivary protein values in caries-free children (3.5 mg/mL).…”

Section: Discussioncontrasting

confidence: 69%

“…Salivary protein concentrations in children with cavitated carious lesions in enamel and dentin (Groups C and D, respectively) resemble the protein concentration previously quantified in saliva of children with S-ECC (grouped without taking caries severity into account) [12], but are higher than the protein concentration detected in caries-free children. Jurczak et al in 2017 [31] obtained higher values in saliva of children with cavitated lesions (ICDAS = 5-6, protein concentration = 1:86 mg/mL) than in saliva of children without cavitated carious lesions (ICDAS = 1-2, protein concentration = 1:79 mg/mL). Nonetheless, both values were higher than the protein concentration measured in cariesfree children (1.65 mg/mL).…”

Section: Discussionmentioning

confidence: 95%

“…Salivary TAC was shown to increase with carious lesion severity (dentin or enamel) in the present study. TAC in saliva of S-ECC children [12] and in children (mean age 2.74 years) with cavitated carious lesions [31] have been reported to be higher than in cariesfree children or in those with noncavitated lesions. However, in patients with carious lesions, salivary TAC tends to decrease as compared to caries-free patients [42].…”

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confidence: 95%

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Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress biomarkers can be found at detectable concentrations in saliva. These salivary biomarkers reflect specific oxidation pathways associated with caries and periodontitis. Our study evaluated the influence of dental caries severity (assessed using the ICCMS™ criteria) on the levels of oxidative stress biomarkers in saliva from children. Unstimulated saliva samples were collected from patients (from one to three years old) in a day care center in Birigui, SP, Brazil, two hours after fasting. Children were divided into four groups (n=30/group), according to caries severity: caries free (group A), early carious lesions (group B), moderate carious lesions (group C), and advanced carious lesions (group D). The following salivary biomarkers were determined: total proteins (TP), measured by the Lowry method; oxidative damage, measured by the TBARS method; total antioxidant capacity (TAC); superoxide dismutase (SOD) enzymatic antioxidant activity; and uric acid (UA) non-enzymatic antioxidant activity. Data were analyzed by ANOVA, followed by the Student-Newman-Keuls test, Pearson and Spearman correlation coefficients, and multivariable linear regression (p<0.05). TP, TAC, SOD enzymatic antioxidant activity, and UA non-enzymatic antioxidant activity increased with caries severity, consequently reducing salivary oxidative damage. It was concluded that higher caries severity increases salivary antioxidant system activity, with consequent reduction in salivary oxidative damage.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 95%

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Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Studies differed in their grouping of caries scores. For example, nine different caries surfaces measures and seven caries teeth measures were identified in this review. Some studies grouped them to classify caries as dentin and enamel lesions while others classified them as initial/early, moderate/established and severe/extensive lesions .…”

Section: Discussionmentioning

confidence: 99%

Caries reporting in studies that used the International Caries Detection and Assessment System: A scoping review

ElSalhy

Ali

Lai

et al. 2018

Comm Dent Oral Epid

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Objective To explore how caries was reported in studies that employed the International Caries Detection and Assessment System (ICDAS). Methods A systematic database search up to August 2017 was carried out using PubMed, Ovid MEDLINE, Cochrane library and ISI Web of Science electronic databases. Only studies that used the ICDAS for dental caries examinations were included. Studies were excluded if the examination was done only for the validation or the calibration of the ICDAS and/or if the examination was not done for the whole dentition. Measures used to report caries were considered. Results A total of 126 papers met the inclusion criteria. Forty‐four different synthesis measures were used to report caries. Most of the studies used a combination of multiple measures to report patient's caries level. These reporting measures cluster into four main groups: the number of individual ICDAS scores (ie, total counts of every score); the number of decayed surfaces/teeth (ie, total counts of combined caries scores for surfaces or teeth); measures of caries experience (ie, total counts of combined caries scores, filled and/or missing surfaces or teeth); and measures of central tendency and dispersion. The number of decayed surfaces and individual ICDAS scores were the most commonly used measures. Three studies used mean ICDAS score (ie, total ICDAS scores divided by the number of teeth), two used mean ICDAS score of carious teeth (ie, total ICDAS scores divided by the number of carious teeth) and two used the maximum ICDAS score (ie, highest ICDAS score recorded). The total ICDAS score was used only once. Many studies synthesized from the ICDAS the number of decayed, missing and filled teeth/surfaces (dmft/DMFT, dmfs/DMFS) as a measure of caries experience. Conclusions There are variations among studies in the utilization of the system to summarize caries. Most studies presented caries data using the categorical characteristics of the ICDAS.

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Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis

Martins

Díaz‐Fabregat

Ramírez‐Carmona

et al. 2022

Archives of Oral Biology

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The role of the saliva antioxidant barrier to reactive oxygen species with regard to caries development

Abstract: Our results indicate that the high levels of antioxidants in saliva increase significantly in children in line with the salivary cariogenic bacterial profiles and caries progression.

Cited by 21 publications

References 34 publications

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Caries reporting in studies that used the International Caries Detection and Assessment System: A scoping review

Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis

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