The role of tissue basophils in the regulation of the neurotransmitter status of tooth pulp in norm and in pathology

Moskovsky, A.V.; Urukov, Y.N.; Viktorov, V N; Воропаева, Л. А.; Lezhenina, S.V.; Moskovskaya, O.I.; Petukhov, D.I.; Tsyganov, V.P.

doi:10.21145/2499-9954-2018-2-51-53

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While, the source of the primaries sensitization can be both primary, natural and acquired, secondary autoantigens occur in the fissured areas of the teeth, under the influence of some physicochemical or infectious factors (theory of altered antigens) [15,21]. In the works of many authors [5,6,9,17,26,27,29] were proved that damage of enamel occurs as a result of immune reaction in the tooth pulp. This conclusion was based that different affections of the dental system are related to any unfavorable condition of the organisms, are beginning of the pulp.…”

Section: Introductionmentioning

confidence: 99%

Morphological condition of the pulp of intact and affected by caries third molars

et al. 2020

View full text Add to dashboard Cite

To date, there is a theory that increased resistance to caries is observed in the teeth, which for any reason underwent destructive changes in the pulp. That is why there is a need to study the impact of pulp vitality on the development of the carious process. The aim of the research was to study the microscopic structure of epoxy sections of intact and carious third molars. We studied 4 intact and 6 carious third molars. For this purpose, specimens were made taking into account the free penetration of the fixative solution into the pulp. To this end, immediately after the tooth was removed, we cut off its roots almost near the crown, preserving the integrity of the latter. The method relied on the impregnation of specimens with epoxy resin, according to the method of epoxy plastination of tooth specimens, developed at the Department of Human Anatomy of Ukrainian Medical Stomatological Academy. The epoxy blocks were cut with a disk into two halves until the hard tissues of the tooth crown were exposed together with the pulp. We found that the hard tissues (dentin and enamel coating) of intact third molars did not have any structural defects. However, their pulp chamber contained mainly an amorphous substance, devoid of any typical pulp tissue structures. That is, the pulp was in a state of complete devolution. Quite the opposite presentation was observed in specimens of carious teeth. We found that their pulp chamber contained quite noticeable tissue structures typical of the dental pulp. It is interesting that in the subodontoblastic layer, in front of the carious alteration of the enamel, there was compaction of the pulp, which may be due to infiltration of perivascular connective tissue by immunocompetent cells. It was found that on the border with carious destruction of enamel, there was a compacted spot of altered dentin, whose matrix was intensely pigmented in brown colour, due to the accumulation of melanin on the dentino-enamel junction. Its excessive formation is associated with the destruction of protein-carbohydrate complexes of organic matter in the deep layers of dentin. We found that the pulp compaction and the focus of carious alteration of the enamel are projectively connected by a radial cord of altered dentin, known in the literature as “dead tracts”. Hence, there is reason to believe that the identified changes indicate a latent form of caries, with a pulpogenic mechanism of development. Thus, it can be argued that the teeth, which for any reason underwent degenerative changes in the pulp, are not prone to carious lesions, whereas in carious teeth, the pulp is active and involved in the pathogenesis of the carious process.

show abstract

Section: Introductionmentioning

confidence: 99%

Morphological condition of the pulp of intact and affected by caries third molars

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Установлено, что мастоциты регулируют микроциркуляцию, репарацию тканей, влияют на рост и созревание волокнистых структур соединительной ткани пародонта, участвуют в иммунопатологических процессах [22]. Кроме того, нейромедиаторные биогенные амины являются индукторами дифференцировки тканей и обеспечивают взаимное влияние эпителиальных и мезенхимальных структур в процессе развития зубов в антенатальном периоде [23].…”

unclassified

Histochemical changes in the tooth and jaw germs of laboratory rats under the influence of ecotoxicants and during perinatal prevention

Chuykin

Шакирова

Кудашкина

et al. 2023

jour

View full text Add to dashboard Cite

Relevance. Unreasonably high pollutant emissions into the environment, the ill-considered use of natural resources and the raw material orientation of exports have led to an environmental crisis in many areas.Purpose. To study the effect of ecotoxicants on the histochemical structure of tooth and jaw germs in laboratory rats and ways to reduce this effect during perinatal prevention.Materials and methods. The experiment included 50 white outbred rats weighing 180-250 grams. All animals formed five groups: 1 control and four experimental. All animals of the experimental groups were subject to gasoline and formaldehyde vapours inhalation exposure; Group 1 (control) was subject to only poisoning with ecotoxicants, Group 2 had peptinsorbent associated with ecotoxicant poisoning, Group 3 – a membrane protector – magnolia vine, Group 4 – beet, Group 5 – peptinsorbent, membrane protector and beet.Results. The histochemical study of tissues around the tooth germs in pup rats born from the control group rats after poisoning with ecotoxicants revealed an increased mast cell number in the tissues compared to intact rats. The samples of Group 2 rats showed that the mast cell number and characteristics practically did not differ from the control group after ecotoxicant poisoning. In the rats of Group 3, the number of mast cells was slightly lower than in the control group. In Group 4, the number of mast cells was not significantly lower than in the control group. In the rats of Group 5, the number of mast cells significantly decreased compared to the control and other experimental groups.Conclusion. Thus, during subchronic poisoning of pregnant female rats with ecotoxicants, the number of mast cells in the gingiva of rat pups increases against the background of microcirculation disorders. The number of mast cells in gingiva significantly decreases and approaches the normal values in rat pups after feeding pregnant rats with the combined mixture (peptinsorbent+membrane protector Schisandra+beetroot).

show abstract

Effect of Bone Marrow Autotransplantation on the Numerical Population of Tryptase-Positive Mast Cells, Heparin Sulfation Degree, and Histamine Content

et al. 2020

View full text Add to dashboard Cite

The role of tissue basophils in the regulation of the neurotransmitter status of tooth pulp in norm and in pathology

Cited by 5 publications

References 0 publications

Morphological condition of the pulp of intact and affected by caries third molars

Morphological condition of the pulp of intact and affected by caries third molars

Histochemical changes in the tooth and jaw germs of laboratory rats under the influence of ecotoxicants and during perinatal prevention

Effect of Bone Marrow Autotransplantation on the Numerical Population of Tryptase-Positive Mast Cells, Heparin Sulfation Degree, and Histamine Content

Contact Info

Product

Resources

About