The role of treatment adherence after myocardial infarction (according to the acute myocardial infarction registry)

Гарганеева, А. А.; Кужелева, Е. А.; Тукиш, О. В.

doi:10.17802/2306-1278-2019-8-4-56-64

Cited by 9 publications

(3 citation statements)

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“…В работе Гарганеевой А. А. с соавт. [12] через 5 лет наблюдения за пациентами, перенесшими ИМ, было установлено, что только 45 % пациентов, выживших после перенесенного ИМ, строго соблюдают рекомендации лечащего врача относительно применяемой медикаментозной терапии. При этом в работе Седых Д. Ю. с соавт.…”

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“…В работе Гарганеевой А. А. с соавт. по данным 5-летнего наблюдения небольшой выборки больных после перенесенного референсного инфаркта миокарда (ИМ), приверженность лечению продемонстрировала даже большее влияние на течение постинфарктного периода, чем соответствие назначенной терапии клиническим рекомендациям [12].…”

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Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)

et al. 2020

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Aim To study long-term compliance with treatment in patients included into the REGistry of pATients after myocArdial infarction (REGATA).Material and methods In 2012–2013, the study included 481 patients with a history of myocardial infarction (MI) who visited the district outpatient clinic. Median age was 72 [62;78] years; men, 51.4 % (n=247); median time from the last MI to the date of inclusion into the registry was 5 [2;9] years. Compliance with treatment was determined with the Morisky-Green questionnaire during telephone contacts with patients at 36 and 48 months (n=230) after the inclusion. Patients scored 4 were considered compliant; patients scored 3 were low-compliant; and patients scored 0-2 were non-compliant. Statistical significance of differences in compliance at 36 and 48 months was assessed with the McNemar test.Results There were no significant differences between the proportions of compliant, low-compliant and non-compliant patients for the analyzed period. However, at 48 months after the inclusion, the number of patients who had difficulties in answering the questionnaire questions significantly increased from 15.5 % to 21.6 % (p=0.04). Analysis of changes in compliance with the treatment for only compliant patients showed that at 36 months from the inclusion, 87 patients remained highly compliant (37.8 %) while at 48 months, only 32 (36.8 %) patients remained compliant with the treatment. Proportion of compliant patients did not significantly differ for men and women, patients younger and older than 60 years, patients with primary MI and reinfarction, prone and not prone to self-management, and for those who used or not the medicine assistance.Conclusion The data obtained as a part of the REGATA registry indicate insufficient long-term compliance with the treatment of after-MI patients with both primary MI and reinfarction, an increasing proportion of patients who are unable to assess their degree of compliance, and decreasing compliance among highly compliant patients during the period between 36 and 48 months of observation. On the whole, there were no significant changes in the compliance with the treatment for 12 months between the first and the second interviews. The proportion of patients compliant with the prescribed drug therapy was significantly lower in the presence of predisposition to self-management.

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Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)

et al. 2020

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“…Поддерживающий этап реабилитации наступает после выписки со второго стационарного этапа и, по сути, продолжается всю последующую жизнь пациента с ИМ. Поэтому крайне важным является долгосрочное сохранение при-верженности к улучшающей прогноз и качество жизни фармакотерапии, а также достижение благоприятных параметров сердечно-сосудистого здоровья за счет своевременного регулярного амбулаторного диспансерного наблюдения [19]. По данным российского многоцентрового исследования, в первые 6 месяцев от ИМ у пациентов младше 75 лет существует проблема невыполнения клинических рекомендаций по количеству посещений кардиолога (у 38,8 % мужчин и 38,5 % женщин) и выполнения диагностических процедур, что может отрицательно сказываться на эффективности ведения таких больных [20].…”

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Sex differences in adherence to treatment in patients with myocardial infarction

Sedykh,

Barbarash

2023

jour

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The aim of the study is to identify factors affecting adherence to treatment in men and women with myocardial infarction (MI).Material and methods. The study included 150 patients diagnosed with MI (47 women and 103 men). Treatment readiness was assessed according to the S.V. Davydov method and with the calculation of the integral indicator of adherence to treatment (IIAT).Results. During 6-month follow-up, men and women with MI were comparable in mortality rates, however, men were more frequently hospitalized for cardiovascular complications. Adherence to treatment was high in both genders. Treatment readiness at the time of MI indicated higher satisfaction with the results of treatment in women, and higher willingness to pay for treatment, higher confidence in the treatment strategy and a higher IIAT in men. Both women and men with MI reported a comparable number of outpatient visits within 6 months (not exceeding 56 %). Only small number of patients reached the target heart rate (HR) and low-density lipoprotein (LDL) content within 6 months. Patients of both genders who reached and not reached the target LDL level and HR did not differ in mortality rates, hospitalizations and adherence to treatment within 6 months. At the same time, patients who reached the target HR, regardless of gender, were more likely to make outpatient postMI visits compared with those who did not reach the targets; men with MI who did not achieve the target HR were less likely to visit a doctor, whereas women with MI who achieved the target HR and LDL were more likely to have a high IIAT during in-patient care and were more willing to pay for further treatment (an exclusive characteristic of women who reached target HR). Moreover, we have identified predictors of IIAT and achievement of HR and LDL in women and men with MI.Conclusions. Patients with MI present with sex-specific factors that are affecting treatment adherence, which should be accounted for in the development of measures for secondary prevention of disease.

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Genetic and nongenetic factors in assessing the prognosis of patients after myocardial infarction with high medical adherence

Переверзева

Якушин

Галус

et al. 2021

Cardiovasc Ther Prev

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Aim. During one-year follow-up, to assess the effect of genetic and nongenetic factors on the risk of poor outcomes in patients after myocardial infarction (MI) with high medical adherence.Material and methods. The study included 250 patients admitted to the hospital due to MI in the period from September 1, 2018 to May 1, 2019 and with a potentially high medical adherence. Twelve months after MI, patients were assessed for adherence to therapy and the effect of genetic and nongenetic factors on the patient prognosis.Results. Within 12 months after MI, 70 (28,0%) patients had a composite endpoint: all-cause death, MI, cerebral stroke, and nonelective coronary revascularization. There were following factors increasing the risk of composite endpoint: non-Q-wave MI (relative risk (RR), 2,63; 95% confidence interval (CI): 1,63-4,25 (p=0,001); left ventricular ejection fraction ≤35% — RR, 2,03; 95% CI: 1,17-3,50 (p<0,0001); CYP2C19 GA/AA genotype (RR, 1,58; 95% CI: 1,06-2,37 (p<0,00001)).Conclusion. The study results allow identifying patients with a high risk of poor outcome: patients with non-Q-wave MI, left ventricular ejection fraction ≤35%, and CYP2C19 GA/AA genotype.

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The role of treatment adherence after myocardial infarction (according to the acute myocardial infarction registry)

Cited by 9 publications

References 8 publications

Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)

Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)

Sex differences in adherence to treatment in patients with myocardial infarction

Genetic and nongenetic factors in assessing the prognosis of patients after myocardial infarction with high medical adherence

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The role of treatment adherence after myocardial infarction (according to the acute myocardial infarction registry)

Cited by 9 publications

References 8 publications

Adherence to the treatment of pa­tients in the long-term supervision period after myocardial infarction (according to the REGATA register)

Adherence to the treatment of pa­tients in the long-term supervision period after myocardial infarction (according to the REGATA register)

Sex differences in adherence to treatment in patients with myocardial infarction

Genetic and nongenetic factors in assessing the prognosis of patients after myocardial infarction with high medical adherence

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Product

Resources

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Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)

Adherence to the treatment of patients in the long-term supervision period after myocardial infarction (according to the REGATA register)